Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Martin L. Wenk"'
Autor:
Reem H. Elbekaei, Sudhir A. Shah, Eias A. Zahalka, Martin L. Wenk, Madhav G. Paranjpe, Michelle Hickman
Publikováno v:
International Journal of Toxicology. 32:48-57
The Tg.rasH2 mouse is a hemizygous transgenic mouse, approved by regulatory agencies for carcinogenicity assessment. However, the absence of a historical database for the incidence of spontaneous neoplasms has subsequently led to reluctance by some p
Autor:
Changyu Zheng, Abraham Nyska, John A. Chiorini, Bruce J. Baum, Richard D. Irwin, Tim Clackson, Molly H. Boyle, Antonis Voutetakis, Benjamin Goldstein, Molly Vallant, Victor M. Rivera, Sandra Afione, Martin L. Wenk
Publikováno v:
Toxicological Sciences. 123:247-255
Clinical gene transfer holds promise for the treatment of many inherited and acquired disorders. A key consideration for all clinical gene transfer applications is the tight control of transgene expression. We have examined the safety and biodistribu
Autor:
Martin L. Wenk, Corinne M. Goldsmith, Antonis Voutetakis, Sandra Afione, Richard D. Irwin, John A. Chiorini, Changyu Zheng, Molly Vallant, Jianghua Wang, Bruce J. Baum
Publikováno v:
Human Gene Therapy. 18:1109-1118
Salivary glands (SGs) have proven useful targets for clinical applications of gene therapeutics. In this toxicology and biodistribution study, which conforms to U.S. Food and Drug Administration Good Laboratory Practice regulations, four doses (10(7)
Autor:
Andrew Kerr, Bruce J. Baum, John A. Chiorini, Changyu Zheng, Richard D. Irwin, Martin L. Wenk, Molly Vallant, Corinne M. Goldsmith, Fumi Mineshiba
Publikováno v:
Human gene therapy. 17(11)
Before conducting a phase 1/2 clinical trial of a serotype 5 adenovirus encoding human aquaporin-1 (AdhAQP1) for the treatment of radiation-damaged salivary glands, we have conducted a detailed toxicity and biodistribution study in adult rats. AdhAQP
Publikováno v:
Archives of toxicology. 80(3)
Fifteen-day and 14-week studies of 2-methylimidazole (2MI) and 4-methylimidazole (4MI) were conducted because of widespread human exposure via ingestion of food products containing the compounds and lack of toxicity data. Groups of five male and five
Autor:
Stephen L. Hoffman, Richard C. Hedstrom, Jon Norman, Flavia Borellini, Peter Hobart, Martin L. Wenk, Thong P. Le, Suezanne E. Parker
Publikováno v:
Human gene therapy. 10(5)
To evaluate the safety of a plasmid DNA vaccine, tissue distribution studies in mice and safety studies in mice and rabbits were conducted with VCL-2510, a plasmid DNA encoding the gene for the malaria circumsporozoite protein from Plasmodium falcipa
Autor:
William K. Kaufmann, Gary J. Smith, Susan A. MacKenzie, Martin L. Wenk, Deborah E. Devor, Bahjat F. Qaqish, Jerry M. Rice, David G. Kaufman
Publikováno v:
Carcinogenesis. 12(9)
Hepatocyte proliferation and damage to DNA were characterized during the initiation phase of carcinogenesis in livers of rats that had received a single administration of the methylating agent methyl(acetoxymethyl)nitrosamine (DMN-OAc). Quiescent non
Autor:
Springer Stephen, Robert A. Squire, Curtis C. Harris, Morton H. Levitt, Martin L. Wenk, Cynthia Mollelo
Publikováno v:
JNCI: Journal of the National Cancer Institute. 60:701-705
A high incidence of pancreatic duct neoplasms was induced in outbred male Syrian golden hamsters following weekly sc injection of N-nitroso-bis(2-hydroxypropyl)amine for life. The first such tumors appeared as early as 16 experimental weeks; the maxi
Publikováno v:
JNCI: Journal of the National Cancer Institute. 58:1531-1535
Methyl(acetoxymethyl)nitrosamine (DMN-OAc) was synthesized and tested for toxicity and carcinogenicity in rats to test the hypothesis that alpha-hydroxylation is required for metabolic activation of dimethylnitrosamine (DMN) to a reactive, proximate
Publikováno v:
JNCI: Journal of the National Cancer Institute. 61:1329-1337
An investigation into the possible relationship between chemical carcinogen induction of rat mammary tumors and the expression of an endogenous retroviral genome was initiated. Mammary tumors were induced in female SD rats with 7,12-dimethylbenz[a]an