Výsledky vyhledávání - "Martin L. Koser"

Figure S1, Figure S2, Figure S3 from β-Catenin mRNA Silencing and MEK Inhibition Display Synergistic Efficacy in Preclinical Tumor Models

Autor: Marc T. Abrams, Bob D. Brown, Weimin Wang, Henryk Dudek, Chengjung Lai, Wendy A. Cyr, Girish R. Chopda, Martin L. Koser, Kevin P. Craig, Xue Shui, Shanthi Ganesh

S1: RNAi mediated dose dependent mRNA silencing in human CRC xenografts. S2: Biodistribution and informal tolerability of DCR-BCAT in wild type mice. S3: Trametinib efficacy in human CRCs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e28d90ca750648bef299d417402b86c
https://doi.org/10.1158/1535-7163.22510105.v1

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Supplementary legends from β-Catenin mRNA Silencing and MEK Inhibition Display Synergistic Efficacy in Preclinical Tumor Models

Autor: Marc T. Abrams, Bob D. Brown, Weimin Wang, Henryk Dudek, Chengjung Lai, Wendy A. Cyr, Girish R. Chopda, Martin L. Koser, Kevin P. Craig, Xue Shui, Shanthi Ganesh

Legends for supplementary figures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f178480014a1d8c607ff17dccd562c
https://doi.org/10.1158/1535-7163.22510102.v1

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Data from β-Catenin mRNA Silencing and MEK Inhibition Display Synergistic Efficacy in Preclinical Tumor Models

Autor: Marc T. Abrams, Bob D. Brown, Weimin Wang, Henryk Dudek, Chengjung Lai, Wendy A. Cyr, Girish R. Chopda, Martin L. Koser, Kevin P. Craig, Xue Shui, Shanthi Ganesh

Colorectal carcinomas harbor well-defined genetic abnormalities, including aberrant activation of Wnt/β-catenin and MAPK pathways, often simultaneously. Although the MAPK pathway can be targeted using potent small-molecule drugs, including BRAF and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35d42d3262376dee76a9cd215ccebec
https://doi.org/10.1158/1535-7163.c.6539509

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supplemental figure legends from Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse Origin

Autor: Marc T. Abrams, Bob D. Brown, Weimin Wang, Satdarshan P. Monga, Henryk Dudek, Chengjung Lai, Kevin Craig, Zakir Siddiquee, Edmond Chipumuro, Purva Pandya, Dongyu Chen, Bo Ying, Xue Shui, Junyan Tao, Girish R. Chopda, Wendy A. Cyr, Martin L. Koser, Shanthi Ganesh

supplemental figure legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada8e18b3ca6e7a0cc20420f69c75b4d
https://doi.org/10.1158/1535-7163.22503670.v1

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Supplemental figures S1-9 from Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse Origin

Figure S1. Components of EnCore-A; Figure S2. Silencing of CTNNB1 mRNA after single-dose or multiple-dose regimens; Figure S3: Comparable activity achieved with a payload with 2'F modifications; Figure S4. Tumor growth inhibition in multiple subcutan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39592eed3dd0b7ac2a00b31300c73a8c
https://doi.org/10.1158/1535-7163.22503673

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