Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Martin L. Duennwald"'
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 4 (2022)
Nrf2 is the master transcriptional regulator of cellular responses against oxidative stress. It is chiefly regulated by Keap1, a substrate adaptor protein that mediates Nrf2 degradation. Nrf2 activity is also influenced by many other protein interact
Externí odkaz:
https://doaj.org/article/227758f717974b838b13ebd902ac4c47
Autor:
Ahmed Salem, Carter J. Wilson, Benjamin S. Rutledge, Allison Dilliott, Sali Farhan, Wing-Yiu Choy, Martin L. Duennwald
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the degeneration of both upper and lower motor neurons in the brain and spinal cord. ALS is associated with protein misfolding and inclusion formation involving RNA-
Externí odkaz:
https://doaj.org/article/863c8b1a8e9c4e4fb7ca720b95b26d33
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Assessing the stability and degradation of proteins is central to the study of cellular biological processes. Here, we describe a novel pulse-chase method to determine the half-life of cellular proteins that overcomes the limitations of other commonl
Externí odkaz:
https://doaj.org/article/ef0ce01a37254f96849064e34697a6ad
Autor:
Vy Ngo, Martin L. Duennwald
Publikováno v:
Antioxidants, Vol 11, Iss 12, p 2345 (2022)
Organisms are continually exposed to exogenous and endogenous sources of reactive oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects on the cell. ROS have important roles in a wide range of physiological process
Externí odkaz:
https://doaj.org/article/013b9aeb472b4cecb78c6e7d890dc6af
Autor:
Allison A. Dilliott, Catherine M. Andary, Meaghan Stoltz, Andrey A. Petropavlovskiy, Sali M. K. Farhan, Martin L. Duennwald
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 8, p 4076 (2022)
Protein misfolding is a common basis of many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Misfolded proteins, such as TDP-43, FUS, Matrin3, and SOD1, mislocalize and form the hallmark cytoplasmic and nuclear inclusions in
Externí odkaz:
https://doaj.org/article/94ad7469656844d4ba5fd1661760aa9e
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100182- (2020)
Summary: We present a detailed protocol that describes the evaluation of the growth and survival of yeast cells by quantitatively analyzing spotting assays. This simple method reproducibly detects and quantifies subtle differences in growth by measur
Externí odkaz:
https://doaj.org/article/e524cecdec0946538dd54a9e32337c08
Publikováno v:
Antioxidants, Vol 11, Iss 2, p 243 (2022)
Cells that experience high levels of oxidative stress respond by inducing antioxidant proteins through activation of the protein transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2). Nrf2 is negatively regulated by the E3 ubiquitin
Externí odkaz:
https://doaj.org/article/51bf6f275dcd40b4ba38b98bf8464e6e
Autor:
Nadun C. Karunatilleke, Courtney S. Fast, Vy Ngo, Anne Brickenden, Martin L. Duennwald, Lars Konermann, Wing-Yiu Choy
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7434 (2021)
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription regulator that plays a pivotal role in coordinating the cellular response to oxidative stress. Through interactions with other proteins, such as Kelch-like ECH-associated protein 1
Externí odkaz:
https://doaj.org/article/e5f5bbf48a3545ab9aedc2cec349dc18
Autor:
Michelle D. Leach, TaeHyung Kim, Sonja E. DiGregorio, Cathy Collins, Zhaolei Zhang, Martin L. Duennwald, Leah E. Cowen
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 1, Pp 95-108 (2017)
Disruption of protein quality control can be detrimental, having toxic effects on single cell organisms and contributing to neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Huntington’s in humans. Here, we examined the effects of
Externí odkaz:
https://doaj.org/article/c12f3f7e00de4fd0afb3ff08b07f3f1b
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
In the past two decades, yeast models have delivered profound insights into basic mechanisms of protein misfolding and the dysfunction of key cellular pathways associated with amyotrophic lateral sclerosis (ALS). Expressing ALS-associated proteins, s
Externí odkaz:
https://doaj.org/article/ccb69c1bceb54e3b8ecc57a84cad8a2b