Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Martin L. Doughty"'
Autor:
Alison A. Chomiak, Yan Guo, Caroline A. Kopsidas, Dennis P. McDaniel, Clara C. Lowe, Hongna Pan, Xiaoming Zhou, Qiong Zhou, Martin L. Doughty, Yuanyi Feng
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104354- (2022)
Summary: The NDE1 gene encodes a scaffold protein essential for brain development. Although biallelic NDE1 loss of function (LOF) causes microcephaly with profound mental retardation, NDE1 missense mutations and copy number variations are associated
Externí odkaz:
https://doaj.org/article/241d88fc941543558b66597fdeea1857
Autor:
Guzal Khayrullina, Kasey E. Moritz, James F. Schooley, Naheed Fatima, Coralie Viollet, Nikki M. McCormack, Jeremy T. Smyth, Martin L. Doughty, Clifton L. Dalgard, Thomas P. Flagg, Barrington G. Burnett
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by loss of alpha motor neurons and skeletal muscle atrophy. The disease is caused by mutations of the SMN1 gene that result in reduced functional expression of surviv
Externí odkaz:
https://doaj.org/article/40e9130eb6944548a569a8859af78a5f
Autor:
Qiong Zhou, Coralie Viollet, Anastasia Efthymiou, Guzal Khayrullina, Kasey E. Moritz, Matthew D. Wilkerson, Gauthaman Sukumar, Clifton L. Dalgard, Martin L. Doughty
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-12 (2019)
Abstract Background Astrocytes respond to central nervous system (CNS) injury and disease by transforming to a reactive astrogliosis cell state that can contribute to either CNS dysfunction or repair. Neuroinflammation is a powerful driver of a harmf
Externí odkaz:
https://doaj.org/article/27bc7001b96044c4a0c8c26733e3dc5a
Autor:
Matthew D. Wilkerson, Savannah Kounelis-Wuillaume, Camille Alba, Teri J. Franks, Martin L. Doughty, Robert L. Kortum, Robert F. Browning, Clifton L. Dalgard, Craig D. Shriver
Publikováno v:
Cancer Research. 83:4622-4622
Lung cancer is a leading cause of cancer deaths worldwide and has complex underlying genetic drivers, subtypes and immune cell types. Molecular analysis of bulk tumors has repeatedly identified key somatic driver genes and subtypes in lung cancer. Ho
Autor:
Qiong Zhou, Yingni Guo, Dennis P. McDaniel, Clara C. Lowe, Alison A. Chomiak, Hongna Pan, Yuanyi Feng, Martin L. Doughty, Xiaoming Zhou
Publikováno v:
iScience. 25:104354
SUMMARYTheNDE1gene encodes a scaffold protein essential for brain development. While biallelicNDE1loss of function (LOF) causes microcephaly with profound mental retardation,NDE1missense mutations and copy number variations are associated with multip
Autor:
Martin L. Doughty, Gauthaman Sukumar, Anastasia G. Efthymiou, Clifton L. Dalgard, Matthew D. Wilkerson, Qiong Zhou, Guzal Khayrullina, Kasey E. Moritz, Coralie Viollet
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-12 (2019)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Astrocytes respond to central nervous system (CNS) injury and disease by transforming to a reactive astrogliosis cell state that can contribute to either CNS dysfunction or repair. Neuroinflammation is a powerful driver of a harmful A1 ast
Autor:
Alison Chomiak, Clara C. Lowe, Yan Guo, Hongna Pan, Dennis McDaniel, Xiaoming Zhou, Qiong Zhou, Martin L. Doughty, Yuanyi Feng
Publikováno v:
SSRN Electronic Journal.
Publikováno v:
Journal of neuroscience researchREFERENCES. 99(6)
Traumatic brain injury is a leading cause of mortality and morbidity in the United States. Acute trauma to the brain triggers chronic secondary injury mechanisms that contribute to long-term neurological impairment. We have developed a single, unilat
Publikováno v:
Brain research. 1748
Traumatic brain injury (TBI) is a substantial cause of disability and death worldwide. Primary head trauma triggers chronic secondary injury mechanisms in the brain that are a focus of therapeutic efforts to treat TBI. Currently, there is no successf