Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Martin L Sos"'
Autor:
Martin Peifer, Jonathan Weiss, Martin L Sos, Mirjam Koker, Stefanie Heynck, Christian Netzer, Stefanie Fischer, Haridas Rode, Daniel Rauh, Jörg Rahnenführer, Roman K Thomas
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8919 (2010)
Despite the successful introduction of potent anti-cancer therapeutics, most of these drugs lead to only modest tumor-shrinkage or transient responses, followed by re-growth of tumors. Combining different compounds has resulted in enhanced tumor cont
Externí odkaz:
https://doaj.org/article/d43d914520a846449df82e6532342907
Autor:
Roland T Ullrich, Thomas Zander, Bernd Neumaier, Mirjam Koker, Takeshi Shimamura, Yannic Waerzeggers, Christa L Borgman, Samir Tawadros, Hongfeng Li, Martin L Sos, Heiko Backes, Geoffrey I Shapiro, Jürgen Wolf, Andreas H Jacobs, Roman K Thomas, Alexandra Winkeler
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3908 (2008)
BACKGROUND: Inhibition of the epidermal growth factor receptor (EGFR) has shown clinical success in patients with advanced non-small cell lung cancer (NSCLC). Somatic mutations of EGFR were found in lung adenocarcinoma that lead to exquisite dependen
Externí odkaz:
https://doaj.org/article/8f3796ed7f8842debdaa3df812da553c
Autor:
Roman K. Thomas, H. Christian Reinhardt, Martin L. Sos, Martin Peifer, Alison M. Schram, F. Thomas Wunderlich, Kevan M. Shokat, Thorsten Persigehl, Reinhard Büttner, Anna Schmitt, Sebastian Klein, Hannah L. Tumbrink, Johannes Brägelmann, Carina Lorenz, Marcel A. Dammert, Dennis Plenker, Lisa Werr
Supplementary Figure from CD74-NRG1 Fusions Are Oncogenic In Vivo and Induce Therapeutically Tractable ERBB2:ERBB3 Heterodimerization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006bacef01864bbdf70bcd37747e88ea
https://doi.org/10.1158/1535-7163.22522992.v1
https://doi.org/10.1158/1535-7163.22522992.v1
Autor:
Matthew Meyerson, Roman K. Thomas, Eric B. Haura, Kwok-Kin Wong, Nathanael S. Gray, Daniel Rauh, Jeonghee Cho, Adam J. Bass, Heidi Greulich, Wendy Winckler, Bruce E. Johnson, Pasi A. Janne, Michael J. Eck, Charles Hatton, Megan Hanna, Ming Sound Tsao, David G. Beer, Jürgen Wolf, Erich Stoelben, Hannie Sietsma, Wim Timens, Harry Groen, Joachim H. Clement, Iver Petersen, Åslaug Helland, Odd Terje Brustugun, Philippe Lorimier, Christian Brambilla, Elisabeth Brambilla, Sascha Ansén, Silvia Querings, Franziska Gabler, Frauke Leenders, Mirjam Koker, Holger Moch, Alex Soltermann, Johannes M. Heuckmann, Thomas Zander, Danila Seidel, Helga B. Salvesen, Robert C. Onofrio, Michael S. Lawrence, Jeffrey R. Simard, Martin Peifer, Stefanie Heynck, Sang Min Lim, Xianming Deng, Jianming Zhang, Wenchu Lin, Brittany A. Woods, Lear E. Brace, Wenjun Zhou, Amit Dutt, Chunxiao Xu, Alex H. Ramos, Martin L. Sos, Peter S. Hammerman
mp3 file (6.8 MB). In the inaugural edition of the Cancer Discovery podcast, Executive Editor Mark Landis talks with Matthew Meyerson about his paper, which describes the identification of the DDR2 kinase as a therapeutic target in squamous cell lung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e5addd2d5a8ac8b634e34fdba42185
https://doi.org/10.1158/2159-8290.22529081
https://doi.org/10.1158/2159-8290.22529081
Autor:
Matthew Meyerson, Roman K. Thomas, Eric B. Haura, Kwok-Kin Wong, Nathanael S. Gray, Daniel Rauh, Jeonghee Cho, Adam J. Bass, Heidi Greulich, Wendy Winckler, Bruce E. Johnson, Pasi A. Janne, Michael J. Eck, Charles Hatton, Megan Hanna, Ming Sound Tsao, David G. Beer, Jürgen Wolf, Erich Stoelben, Hannie Sietsma, Wim Timens, Harry Groen, Joachim H. Clement, Iver Petersen, Åslaug Helland, Odd Terje Brustugun, Philippe Lorimier, Christian Brambilla, Elisabeth Brambilla, Sascha Ansén, Silvia Querings, Franziska Gabler, Frauke Leenders, Mirjam Koker, Holger Moch, Alex Soltermann, Johannes M. Heuckmann, Thomas Zander, Danila Seidel, Helga B. Salvesen, Robert C. Onofrio, Michael S. Lawrence, Jeffrey R. Simard, Martin Peifer, Stefanie Heynck, Sang Min Lim, Xianming Deng, Jianming Zhang, Wenchu Lin, Brittany A. Woods, Lear E. Brace, Wenjun Zhou, Amit Dutt, Chunxiao Xu, Alex H. Ramos, Martin L. Sos, Peter S. Hammerman
Supplementary Table 1 from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db13f0f0711315c79b59f97a73ae407
https://doi.org/10.1158/2159-8290.22529072
https://doi.org/10.1158/2159-8290.22529072
Autor:
Roman K. Thomas, H. Christian Reinhardt, Martin L. Sos, Martin Peifer, Alison M. Schram, F. Thomas Wunderlich, Kevan M. Shokat, Thorsten Persigehl, Reinhard Büttner, Anna Schmitt, Sebastian Klein, Hannah L. Tumbrink, Johannes Brägelmann, Carina Lorenz, Marcel A. Dammert, Dennis Plenker, Lisa Werr
NRG1 fusions are recurrent somatic genome alterations occurring across several tumor types, including invasive mucinous lung adenocarcinomas and pancreatic ductal adenocarcinomas and are potentially actionable genetic alterations in these cancers. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb5b84d85a40ab02fd23cb6c8c99405
https://doi.org/10.1158/1535-7163.c.6543543.v1
https://doi.org/10.1158/1535-7163.c.6543543.v1
Autor:
Matthew Meyerson, Roman K. Thomas, Eric B. Haura, Kwok-Kin Wong, Nathanael S. Gray, Daniel Rauh, Jeonghee Cho, Adam J. Bass, Heidi Greulich, Wendy Winckler, Bruce E. Johnson, Pasi A. Janne, Michael J. Eck, Charles Hatton, Megan Hanna, Ming Sound Tsao, David G. Beer, Jürgen Wolf, Erich Stoelben, Hannie Sietsma, Wim Timens, Harry Groen, Joachim H. Clement, Iver Petersen, Åslaug Helland, Odd Terje Brustugun, Philippe Lorimier, Christian Brambilla, Elisabeth Brambilla, Sascha Ansén, Silvia Querings, Franziska Gabler, Frauke Leenders, Mirjam Koker, Holger Moch, Alex Soltermann, Johannes M. Heuckmann, Thomas Zander, Danila Seidel, Helga B. Salvesen, Robert C. Onofrio, Michael S. Lawrence, Jeffrey R. Simard, Martin Peifer, Stefanie Heynck, Sang Min Lim, Xianming Deng, Jianming Zhang, Wenchu Lin, Brittany A. Woods, Lear E. Brace, Wenjun Zhou, Amit Dutt, Chunxiao Xu, Alex H. Ramos, Martin L. Sos, Peter S. Hammerman
Supplementary Figures 1-7 from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531f85fe4c83a1a8d4a9016eb995d4c2
https://doi.org/10.1158/2159-8290.22529075.v1
https://doi.org/10.1158/2159-8290.22529075.v1
Autor:
Matthew Meyerson, Roman K. Thomas, Eric B. Haura, Kwok-Kin Wong, Nathanael S. Gray, Daniel Rauh, Jeonghee Cho, Adam J. Bass, Heidi Greulich, Wendy Winckler, Bruce E. Johnson, Pasi A. Janne, Michael J. Eck, Charles Hatton, Megan Hanna, Ming Sound Tsao, David G. Beer, Jürgen Wolf, Erich Stoelben, Hannie Sietsma, Wim Timens, Harry Groen, Joachim H. Clement, Iver Petersen, Åslaug Helland, Odd Terje Brustugun, Philippe Lorimier, Christian Brambilla, Elisabeth Brambilla, Sascha Ansén, Silvia Querings, Franziska Gabler, Frauke Leenders, Mirjam Koker, Holger Moch, Alex Soltermann, Johannes M. Heuckmann, Thomas Zander, Danila Seidel, Helga B. Salvesen, Robert C. Onofrio, Michael S. Lawrence, Jeffrey R. Simard, Martin Peifer, Stefanie Heynck, Sang Min Lim, Xianming Deng, Jianming Zhang, Wenchu Lin, Brittany A. Woods, Lear E. Brace, Wenjun Zhou, Amit Dutt, Chunxiao Xu, Alex H. Ramos, Martin L. Sos, Peter S. Hammerman
Supplementary Figure Legends 1-7 from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5345540f2603d5198978a03ea047dd
https://doi.org/10.1158/2159-8290.22529078.v1
https://doi.org/10.1158/2159-8290.22529078.v1
Autor:
William Pao, Paul A. Bunn, Marc Ladanyi, Dora Dias-Santagata, Mark G. Kris, Martin L. Sos, Gregory J. Riely, Wilbur A. Franklin, Steven M. Dubinett, Edward B. Garon, Jeffrey A. Engelman, Hidefumi Sasaki, Yumei Pan, Lynne Berry, Cindy L. Vnencak-Jones, David Ross Camidge, Teresa Moran, Charles M. Rudin, Xi Chen, Christine M. Lovly, Maria E. Arcila, Lecia V. Sequist, Kadoaki Ohashi
Purpose: We sought to determine the frequency and clinical characteristics of patients with lung cancer harboring NRAS mutations. We used preclinical models to identify targeted therapies likely to be of benefit against NRAS-mutant lung cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac13d672a5a9b37b59ae1ab83a2722a
https://doi.org/10.1158/1078-0432.c.6521325
https://doi.org/10.1158/1078-0432.c.6521325
Autor:
Roman K. Thomas, William Pao, Daniel Rauh, Christian Grütter, Christine M. Lovly, Jonathan Weiss, Martin Peifer, Mirjam Koker, Hyatt Balke-Want, Stefanie Heynck, Martin L. Sos, Michael Hölzel, Johannes M. Heuckmann
PDF file - 82K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2e6c8b154a248944e535dac62cc353
https://doi.org/10.1158/1078-0432.22443720
https://doi.org/10.1158/1078-0432.22443720