Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Martin Kuentz"'
Publikováno v:
Pharmaceutical Sciences, Vol 30, Iss 1, Pp 109-115 (2024)
Background: There is only limited data for solubility of codeine phosphate in binary systems available, which comes with uncertainties about the prediction accuracy of common thermodynamic models. Methods: This study investigated the codeine phosphat
Externí odkaz:
https://doaj.org/article/9fa7363367bd4ae6a99cfc3ca8ba2cd2
Autor:
Harriet Bennett-Lenane, Joseph P. O’Shea, Jack D. Murray, Alexandra-Roxana Ilie, René Holm, Martin Kuentz, Brendan T. Griffin
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1398 (2021)
In response to the increasing application of machine learning (ML) across many facets of pharmaceutical development, this pilot study investigated if ML, using artificial neural networks (ANNs), could predict the apparent degree of supersaturation (a
Externí odkaz:
https://doaj.org/article/7b06bc13a1894a9ba8b0eaab5f9147a4
Publikováno v:
Pharmaceutics, Vol 12, Iss 6, p 564 (2020)
Increasing numbers of beyond Rule-of-Five drugs are emerging from discovery pipelines, generating a need for bio-enabling formulation approaches, such as lipid-based formulations (LBF), to ensure maximal in vivo exposure. However, many drug candidate
Externí odkaz:
https://doaj.org/article/e8396e284ac84c49a16691b9fa38b952
Autor:
Felix Ditzinger, Daniel J. Price, Anita Nair, Johanna Becker-Baldus, Clemens Glaubitz, Jennifer B. Dressman, Christoph Saal, Martin Kuentz
Publikováno v:
Pharmaceutics, Vol 11, Iss 11, p 577 (2019)
Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer-based amorphous formulations manufactured by spray drying, hot melt extrus
Externí odkaz:
https://doaj.org/article/84d04692b34543d8b7058a540fcff24f
Publikováno v:
Pharmaceutics, Vol 11, Iss 12, p 625 (2019)
Solid dispersions provide a key technology to formulate poorly water-soluble drugs, and a main task of early development is appropriate selection of polymer. This study investigates the use of a novel rheology-based approach to evaluate miscibility a
Externí odkaz:
https://doaj.org/article/331d9b69f0644e25be0cfca314efa8a0
Publikováno v:
Pharmaceutics, Vol 11, Iss 4, p 174 (2019)
Solid dispersions are important supersaturating formulations to orally deliver poorly water-soluble drugs. A most important process technique is hot melt extrusion but process requirements limit the choice of suitable polymers. One way around this li
Externí odkaz:
https://doaj.org/article/666b372fe10c4b319fdc43320629d5b2
Publikováno v:
Journal of Excipients and Food Chemicals, Vol 5, Iss 2 (2016)
There has recently been increasing interest in understanding the impact of intestinal supersaturation on the absorption of poorly water-soluble drugs. Focus has been mostly on the effect of excipients on maintaining drug supersaturation. The aim of t
Externí odkaz:
https://doaj.org/article/ec4136f0054e4ed09c3be50ba397a79e
Publikováno v:
Pharmaceutics, Vol 10, Iss 3, p 94 (2018)
Background: Dynamic light scattering (DLS) is an important tool to characterize colloidal systems and adequate sizing is particularly critical in the field of protein formulations. Among the different factors that can influence the measurement result
Externí odkaz:
https://doaj.org/article/375095afa04a4e36a091c22b87705080
Publikováno v:
Pharmaceutical Sciences.
Background: There is only limited data for solubility of codeine phosphate in binary systems available, which comes with uncertainties about the prediction accuracy of common thermodynamic models. Methods: This study investigated the codeine phosphat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4342488f01b041ae72dd7afbefc5ec9b
https://doi.org/10.34172/ps.2023.2
https://doi.org/10.34172/ps.2023.2
Publikováno v:
Journal of Pharmaceutical Sciences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b174c0338cf5b755fbed285d40bad06
https://doi.org/10.1016/j.xphs.2023.02.013
https://doi.org/10.1016/j.xphs.2023.02.013