Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Martin Kraupp"'
Autor:
Richard Marz, Martin Kraupp
Publikováno v:
General Pharmacology: The Vascular System. 26:1185-1190
1. 1. The kinetic properties and the mechanism of nucleobase transport and transport inhibition are briefly reviewed. 2. 2. Many purine derivatives even when bearing large substituents on N9 and C6 are inhibitors of nucleobase transport, some are als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b774ab27843db9cb761685a829c81dcb
https://doi.org/10.1016/0306-3623(95)00005-l
https://doi.org/10.1016/0306-3623(95)00005-l
Publikováno v:
Biochemical Pharmacology. 48:41-47
Papaverine was found to be an effective inhibitor of hypoxanthine transport not only in human erythrocytes, but also in the human cell lines HL60 (myeloic) and U937 (monocytic). IC50 values for inhibition of hypoxanthine influx ranged from 6 to 20 mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be65c7d9ff0f7b1387958dfd3c91e3ce
https://doi.org/10.1016/0006-2952(94)90221-6
https://doi.org/10.1016/0006-2952(94)90221-6
Autor:
Thomas Stockner, Zahida Parveen, Michael Freissmuth, Gerhard F. Ecker, Peter Chiba, S. Pferschy, Caterina Bentele, Martin Kraupp
Publikováno v:
Molecular pharmacology. 79(3)
The human multispecific drug efflux transporter P-glycoprotein (P-gp) causes drug resistance and modulates the pharmacological profile of systemically administered medicines. It has arisen from a homodimeric ancestor by gene duplication. Crystal stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aeb66d66709d31fa0501319389ee43f
https://pubmed.ncbi.nlm.nih.gov/21177413
https://pubmed.ncbi.nlm.nih.gov/21177413
Autor:
Martin Kraupp, Marz R
Publikováno v:
Europe PubMed Central
Membrane transport of nucleobases and nucleosides has been an actively pursued research field for the past 25 years. Not only are these substances of physiological interest; derivatives are in clinical use or under investigation for their pharmacolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6a2831bef545feb752094b97798de80b
https://pubmed.ncbi.nlm.nih.gov/8533427
https://pubmed.ncbi.nlm.nih.gov/8533427
Publikováno v:
Biochemical pharmacology. 45(4)
The mechanism of allopurinol [4-hydroxypyrazolo(3, 4- d )pyrimidine] transport into human erythrocytes was investigated with an inhibitor stop assay. Allopurinol transport could be resolved into two components: (1) a saturable system and (2) a non-sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c1e0d19ad2d4ac022d7f5269354472
https://pubmed.ncbi.nlm.nih.gov/8452564
https://pubmed.ncbi.nlm.nih.gov/8452564
Autor:
Peter Chiba, Werner Kommer, Richard Marz, Mehrdad Baghestanian, Mehrdad Razavi, Gerhard Prager, Martin Kraupp
Publikováno v:
Biochimica et biophysica acta. 1070(1)
Transport of adenine and hypoxanthine in human erythrocytes proceeds via two mechanisms: (1) a common carrier for both nucleobases and (2) unsaturable permeation 4-5-fold faster for adenine for hypoxanthine. The latter process was resistant to inacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f7cd1604a322620f9e6649e50212fd
https://pubmed.ncbi.nlm.nih.gov/1751522
https://pubmed.ncbi.nlm.nih.gov/1751522
Publikováno v:
Advances in Enzyme Regulation. 21:239-256
Purine bases and purine nucleosides pass the cell membrane by facilitated diffusion. For purine bases two different carrier proteins seem to exist. Purine bases are trapped intracellularly immediately after passage of the cell membrane by the action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc259368a9b5b33d457085239830b69
https://doi.org/10.1016/0065-2571(83)90017-1
https://doi.org/10.1016/0065-2571(83)90017-1
Autor:
Peter G.W. Plagemann, Martin Kraupp
Publikováno v:
Biochemical Pharmacology. 35:2559-2567
The transport of 500 microM uridine by human erythrocytes and S49, P388 and L1210 mouse leukemia cells, Chinese hamster ovary (CHO) cells and Novikoff rat hepatoma cells was inhibited strongly by dilazep and hexobendine with similar concentration dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09e0021328e238ae4a8eeac23a41ed2
https://doi.org/10.1016/0006-2952(86)90054-7
https://doi.org/10.1016/0006-2952(86)90054-7
Publikováno v:
Clinical Biochemistry. 16:31-37
Congenital enzyme defects of purine synthesis de novo and the salvage pathway are responsible for excessive uric acid production and are often associated with hyperuricemia and gout. On the other hand, defects of enzymes essential for the purine nucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9018fde2833935530a35d1e943b8c9
https://doi.org/10.1016/s0009-9120(83)94347-3
https://doi.org/10.1016/s0009-9120(83)94347-3
Publikováno v:
Journal of Cellular Physiology. 125:330-336
Using rapid kinetic techniques, we have determined the kinetics of zero-trans influx and equilibrium exchange of adenosine, and its uptake and in situ phosphorylation at 25 degrees C in human erythrocytes which were pretreated with 2'-deoxycoformycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6afe26af142f5282c86b1412be4c27
https://doi.org/10.1002/jcp.1041250223
https://doi.org/10.1002/jcp.1041250223