Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Martin Karpefors"'
Publikováno v:
Clinical trials (London, England).
Background: Hierarchical composite endpoints are complex endpoints combining outcomes of different types and different clinical importance into an ordinal outcome that prioritizes the clinically most important (e.g. most severe) event of a patient. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e03c0f5ffb8e0cd29529dc967318f1
https://pubmed.ncbi.nlm.nih.gov/36373800
https://pubmed.ncbi.nlm.nih.gov/36373800
Publikováno v:
Journal of Asthma and Allergy
Jonathan Corren,1 Martin Karpefors,2 Åsa Hellqvist,3 Jane R Parnes,4 Gene Colice5 1Departments of Medicine and Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; 2Data Science and AI, AstraZeneca, Gothenburg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1724697d31fdeeddad9d0db46b2646
http://europepmc.org/articles/PMC7810672
http://europepmc.org/articles/PMC7810672
Publikováno v:
B101. NEW BIOLOGICAL TREATMENTS FOR ASTHMA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ed966b61d5b5a894027359d1578a72a
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4257
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4257
Publikováno v:
Diabetes, Obesity and Metabolism. 19:1295-1305
Aim To quantify the effect of weight loss on glycated haemoglobin (HbA1c) at group level, based on data from published weight loss trials in overweight and obese patients with type 2 diabetes (T2D). Methods A systematic literature search in MEDLINE,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a3c290fd28b357ef598acd7c6e634e
https://doi.org/10.1111/dom.12971
https://doi.org/10.1111/dom.12971
Publikováno v:
ISCBI
The technology and techniques for bio-sensors are rapidly evolving. Accordingly, there is significant business interest to identify upcoming technologies and new targets for the near future. Text information from internet reflects much of the recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81bcad265d99e8df5a7759cb805e2883
https://doi.org/10.1109/iscbi.2018.00027
https://doi.org/10.1109/iscbi.2018.00027
Publikováno v:
Endocrinology. 156:1237-1241
The individual weight loss response to obesity treatment is diverse. Here we test the hypothesis that the weight loss response to the CB1 receptor antagonist rimonabant is influenced by endogenous levels of receptor agonists. We show that baseline an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789102c636589362987130e85b4e360d
https://doi.org/10.1210/en.2014-1730
https://doi.org/10.1210/en.2014-1730
Autor:
Chris Chamberlain, Sarah R. Bujac, Susan Grandy, Anne-Marie Boothman, Angelo Del Parigi, Martin Karpefors, Tom Liptrot, Jennifer Sugg
Publikováno v:
Diabetes Therapy
Introduction This study aimed to determine if data mining methodologies could identify reproducible predictors of dapagliflozin-specific treatment response in the phase 3 clinical program dataset. Methods Baseline and early treatment response variabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3d61775a3ff57715461182efeef8fe
https://doi.org/10.1007/s13300-014-0090-y
https://doi.org/10.1007/s13300-014-0090-y
Autor:
Martin Karpefors, James Weatherall
Publikováno v:
J Am Med Inform Assoc
Background In contrast to efficacy, safety hypotheses of clinical trials are not always pre-specified, and therefore, the safety interpretation work of a trial tends to be more exploratory, often reactive, and the analysis more statistically and grap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e301694db36879420fbe20bd46026998
https://pubmed.ncbi.nlm.nih.gov/29579254
https://pubmed.ncbi.nlm.nih.gov/29579254
Autor:
Gwen Gilderson, Robert B. Gennis, Peter Brzezinski, Pia Ädelroth, Farol L. Tomson, Martin Karpefors
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1459(2-3):533-539
We have investigated the electron-proton coupling during the peroxy (P(R)) to oxo-ferryl (F) and F to oxidised (O) transitions in cytochrome c oxidase from Rhodobacter sphaeroides. The kinetics of these reactions were investigated in two different mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f87cd66eb063ca60bf0445a4e03f43
Publikováno v:
Biochemistry. 39:5045-5050
We have investigated the dynamics of proton equilibration within the proton-transfer pathway of cytochrome c oxidase from bovine heart that is used for the transfer of both substrate and pumped protons during reaction of the reduced enzyme with oxyge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac397b71c80e4360fffde700ae90c90
https://doi.org/10.1021/bi9925221
https://doi.org/10.1021/bi9925221