Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Martin Kampmann"'
Autor:
Kun Leng, Brendan Rooney, Frank McCarthy, Wenlong Xia, Indigo V. L. Rose, Sophie Bax, Marcus Chin, Saeed Fathi, Kari A. Herrington, Manuel Leonetti, Aimee Kao, Stephen P. J. Fancy, Joshua E. Elias, Martin Kampmann
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Astrocytes respond and contribute to neuroinflammation by adopting inflammatory reactive states. Although recent efforts have characterized the gene expression signatures associated with these reactive states, the cell biology underlying inf
Externí odkaz:
https://doaj.org/article/3362c7cd0c774b99bc1e41cc97a52ae6
Autor:
Yun Lan, Sophie Wilhelmina van Leur, Julia Ayano Fernando, Ho Him Wong, Martin Kampmann, Lewis Siu, Jingshu Zhang, Mingyuan Li, John M. Nicholls, Sumana Sanyal
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Infection by many (+)RNA viruses is accompanied by ER-expansion and membrane remodelling to form viral replication organelles, followed by assembly and secretion of viral progenies. We previously identified that virus-triggered lipophagy was
Externí odkaz:
https://doaj.org/article/06e25eb0898c4aafac875ea13a542e65
Autor:
Kun Leng, Martin Kampmann
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-13 (2022)
Abstract Our understanding of neurological diseases has been tremendously enhanced over the past decade by the application of new technologies. Genome-wide association studies have highlighted glial cells as important players in diseases. Single-cell
Externí odkaz:
https://doaj.org/article/f82e88347a7847b3a8f4776c4e8bbee6
Autor:
Hyosung Kim, Kun Leng, Jinhee Park, Alexander G. Sorets, Suil Kim, Alena Shostak, Rebecca J. Embalabala, Kate Mlouk, Ketaki A. Katdare, Indigo V. L. Rose, Sarah M. Sturgeon, Emma H. Neal, Yan Ao, Shinong Wang, Michael V. Sofroniew, Jonathan M. Brunger, Douglas G. McMahon, Matthew S. Schrag, Martin Kampmann, Ethan S. Lippmann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Inflammation of brain endothelial cells is seen in neurodegenerative conditions and in aging. Here the authors examine the role of astrocytes in blood brain barrier function using an iPSC-derived cell co-culture model.
Externí odkaz:
https://doaj.org/article/106dfd6155e1471aa3dfbd079fe49bd4
Autor:
Huihui Li, Caroline Guglielmetti, Yoshitaka J. Sei, Misha Zilberter, Lydia M. Le Page, Lauren Shields, Joyce Yang, Kevin Nguyen, Brice Tiret, Xiao Gao, Neal Bennett, Iris Lo, Talya L. Dayton, Martin Kampmann, Yadong Huang, Jeffrey C. Rathmell, Matthew Vander Heiden, Myriam M. Chaumeil, Ken Nakamura
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112335- (2023)
Summary: Neurons require large amounts of energy, but whether they can perform glycolysis or require glycolysis to maintain energy remains unclear. Using metabolomics, we show that human neurons do metabolize glucose through glycolysis and can rely o
Externí odkaz:
https://doaj.org/article/5e1e130f24524f59b205438e36d2ce00
Autor:
Mona Rheinberger, Ana Luisa Costa, Martin Kampmann, Dunja Glavas, Iart Luca Shytaj, Sheetal Sreeram, Carlotta Penzo, Nadine Tibroni, Yoelvis Garcia-Mesa, Konstantin Leskov, Oliver T. Fackler, Kristian Vlahovicek, Jonathan Karn, Bojana Lucic, Carl Herrmann, Marina Lusic
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112110- (2023)
Summary: HIV-1 encounters the hierarchically organized host chromatin to stably integrate and persist in anatomically distinct latent reservoirs. The contribution of genome organization in HIV-1 infection has been largely understudied across differen
Externí odkaz:
https://doaj.org/article/6d1fc39be46e44d28da6d139b84c5bcf
Autor:
Joseph M Replogle, Jessica L Bonnar, Angela N Pogson, Christina R Liem, Nolan K Maier, Yufang Ding, Baylee J Russell, Xingren Wang, Kun Leng, Alina Guna, Thomas M Norman, Ryan A Pak, Daniel M Ramos, Michael E Ward, Luke A Gilbert, Martin Kampmann, Jonathan S Weissman, Marco Jost
Publikováno v:
eLife, Vol 11 (2022)
CRISPR interference (CRISPRi) enables programmable, reversible, and titratable repression of gene expression (knockdown) in mammalian cells. Initial CRISPRi-mediated genetic screens have showcased the potential to address basic questions in cell biol
Externí odkaz:
https://doaj.org/article/af03cd98b4f34c128b98cd963fa2ba56
Autor:
Neal K. Bennett, Mai K. Nguyen, Maxwell A. Darch, Hiroki J. Nakaoka, Derek Cousineau, Johanna ten Hoeve, Thomas G. Graeber, Markus Schuelke, Emin Maltepe, Martin Kampmann, Bryce A. Mendelsohn, Jean L. Nakamura, Ken Nakamura
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Energy metabolism and ATP levels are controlled by an interlocking network of pathways. Here, the authors apply a genome-wide CRISPR screen to define genes that increase or decrease ATP levels to define the “ATPome”, a map of pathways that contri
Externí odkaz:
https://doaj.org/article/f277e255c7dc4504b568ae47fe3e9af8
Publikováno v:
Journal of International Medical Research, Vol 50 (2022)
Objective This study was performed to evaluate the therapeutic effect and diagnostic value of a novel nasopharyngeal stent (Naśtent; Corinium Medical Equipment Ltd., Cirencester, UK). The Naśtent is designed to stent palatal collapse in patients wi
Externí odkaz:
https://doaj.org/article/dfedc47d7d4c4814a93a6f3838863b4f
Autor:
Celeste M. Karch, Aimee W. Kao, Anna Karydas, Khadijah Onanuga, Rita Martinez, Andrea Argouarch, Chao Wang, Cindy Huang, Peter Dongmin Sohn, Kathryn R. Bowles, Salvatore Spina, M. Catarina Silva, Jacob A. Marsh, Simon Hsu, Derian A. Pugh, Nupur Ghoshal, Joanne Norton, Yadong Huang, Suzee E. Lee, William W. Seeley, Panagiotis Theofilas, Lea T. Grinberg, Fermin Moreno, Kathryn McIlroy, Bradley F. Boeve, Nigel J. Cairns, John F. Crary, Stephen J. Haggarty, Justin K. Ichida, Kenneth S. Kosik, Bruce L. Miller, Li Gan, Alison M. Goate, Sally Temple, Carolina Alquezar, Kathryn Bowles, David Butler, Israel Hernandez, Valerie Hennes, Martin Kampmann
Publikováno v:
Stem Cell Reports, Vol 13, Iss 5, Pp 939-955 (2019)
Summary: Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by diverse neuropsychiatric, cognitive, and motor impairments. Autosomal domina
Externí odkaz:
https://doaj.org/article/598d132842794126ace928eb080d817b