Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Martin K. Thomsen"'
Autor:
Huiqiang Cai, Bin Zhang, Johanne Ahrenfeldt, Justin V. Joseph, Maria Riedel, Zongliang Gao, Sofie K. Thomsen, Ditte S. Christensen, Rasmus O. Bak, Henrik Hager, Mikkel H. Vendelbo, Xin Gao, Nicolai Birkbak, Martin K. Thomsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Metastatic prostate cancer (PCa) poses a significant therapeutic challenge with high mortality rates. Utilizing CRISPR-Cas9 in vivo, we target five potential tumor suppressor genes (Pten, Trp53, Rb1, Stk11, and RnaseL) in the mouse prostate,
Externí odkaz:
https://doaj.org/article/b26426d9b48c4a0dba41510dd87eb43f
Autor:
Line S. Reinert, Katarína Lopušná, Henriette Winther, Chenglong Sun, Martin K. Thomsen, Ramya Nandakumar, Trine H. Mogensen, Morten Meyer, Christian Vægter, Jens R. Nyengaard, Katherine A. Fitzgerald, Søren R. Paludan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The cGAS–STING pathway is an important immune defence pathway against viral infection, including HSV-1. Here the authors use an HSV-1 encephalitis model and show microglia are the main producers of type 1 interferons that induce antiviral activity
Externí odkaz:
https://doaj.org/article/9c9ff79ecf304100a3671a4551b19557
Autor:
Christian K. Holm, Stine H. Rahbek, Hans Henrik Gad, Rasmus O. Bak, Martin R. Jakobsen, Zhaozaho Jiang, Anne Louise Hansen, Simon K. Jensen, Chenglong Sun, Martin K. Thomsen, Anders Laustsen, Camilla G. Nielsen, Kasper Severinsen, Yingluo Xiong, Dara L. Burdette, Veit Hornung, Robert Jan Lebbink, Mogens Duch, Katherine A. Fitzgerald, Shervin Bahrami, Jakob Giehm Mikkelsen, Rune Hartmann, Søren R. Paludan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Stimulator of interferon genes (STING) is known to be involved in defence against DNA viruses, but its role in the control of RNA viruses remains poorly explored. Here the authors show that STING participates in an innate immune response to RNA virus
Externí odkaz:
https://doaj.org/article/00f2e460d4a44590a591e3a422a9f087
Autor:
Zongliang Gao, Sujan Ravendran, Nanna S. Mikkelsen, Jakob Haldrup, Huiqiang Cai, Xiangning Ding, Søren R. Paludan, Martin K. Thomsen, Jacob Giehm Mikkelsen, Rasmus O. Bak
Publikováno v:
Gao, Z, Ravendran, S, Mikkelsen, N S, Haldrup, J, Cai, H, Ding, X, Paludan, S R, Thomsen, M K, Mikkelsen, J G & Bak, R O 2022, ' A truncated reverse transcriptase enhances prime editing by split AAV vectors ', Molecular Therapy, vol. 30, no. 9, pp. 2942-2951 . https://doi.org/10.1016/j.ymthe.2022.07.001
Prime editing is a new CRISPR-based, genome-editing technology that relies on the prime editor (PE), a fusion protein of Cas9-nickase and M-MLV reverse transcriptase (RT), and a prime editing guide RNA (pegRNA) that serves both to target PE to the de
Autor:
Nicolai J. Birkbak, Nicholas McGranahan, Lasse Maretty, Martin K. Thomsen, Judit Kisistók, Mateo Sokač, Johanne Ahrenfeldt, Ditte S. Christensen
Supplementary Data from Treatment Represents a Key Driver of Metastatic Cancer Evolution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f96ddda436f0a2cc809e1c21c59609a
https://doi.org/10.1158/0008-5472.22431749
https://doi.org/10.1158/0008-5472.22431749
Autor:
Nicolai J. Birkbak, Nicholas McGranahan, Lasse Maretty, Martin K. Thomsen, Judit Kisistók, Mateo Sokač, Johanne Ahrenfeldt, Ditte S. Christensen
Metastasis is the main cause of cancer death, yet the evolutionary processes behind it remain largely unknown. Here, through analysis of large panel-based genomic datasets from the AACR Genomics Evidence Neoplasia Information Exchange project, includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1feecd178204e8cbc10c9dd1799da198
https://doi.org/10.1158/0008-5472.c.6513971
https://doi.org/10.1158/0008-5472.c.6513971
Autor:
Nicolai J. Birkbak, Nicholas McGranahan, Lasse Maretty, Martin K. Thomsen, Judit Kisistók, Mateo Sokač, Johanne Ahrenfeldt, Ditte S. Christensen
Supplementary Figure from Treatment Represents a Key Driver of Metastatic Cancer Evolution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2e49acc4d081b40c489972fba8a109
https://doi.org/10.1158/0008-5472.22431746
https://doi.org/10.1158/0008-5472.22431746
Autor:
Amanda Swain, Colin S. Cooper, Christopher M. Butler, Francis L. Martin, Paras B. Singh, Narasimhan Ragavan, Jack Cuzick, Peter Scardino, Victor E. Reuter, Henrik Møller, Daniel M. Berney, Gabrielle Fisher, Christopher S. Foster, Kathryn S.E. Cheah, Sarah Wynn, Laurence Ambroisine, Martin K. Thomsen
Supplementary Figure 1 from SOX9 Elevation in the Prostate Promotes Proliferation and Cooperates with PTEN Loss to Drive Tumor Formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68b8a221707b6a329749a3476afd8c7
https://doi.org/10.1158/0008-5472.22387238
https://doi.org/10.1158/0008-5472.22387238
Autor:
Amanda Swain, Colin S. Cooper, Christopher M. Butler, Francis L. Martin, Paras B. Singh, Narasimhan Ragavan, Jack Cuzick, Peter Scardino, Victor E. Reuter, Henrik Møller, Daniel M. Berney, Gabrielle Fisher, Christopher S. Foster, Kathryn S.E. Cheah, Sarah Wynn, Laurence Ambroisine, Martin K. Thomsen
Supplementary Figure 3 from SOX9 Elevation in the Prostate Promotes Proliferation and Cooperates with PTEN Loss to Drive Tumor Formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2890e192b24d316e32457411811203a7
https://doi.org/10.1158/0008-5472.22387232.v1
https://doi.org/10.1158/0008-5472.22387232.v1
Autor:
Amanda Swain, Colin S. Cooper, Christopher M. Butler, Francis L. Martin, Paras B. Singh, Narasimhan Ragavan, Jack Cuzick, Peter Scardino, Victor E. Reuter, Henrik Møller, Daniel M. Berney, Gabrielle Fisher, Christopher S. Foster, Kathryn S.E. Cheah, Sarah Wynn, Laurence Ambroisine, Martin K. Thomsen
Supplementary Figure 2 from SOX9 Elevation in the Prostate Promotes Proliferation and Cooperates with PTEN Loss to Drive Tumor Formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7295b18ed27bdb0112c2b1efd2bf6eed
https://doi.org/10.1158/0008-5472.22387235
https://doi.org/10.1158/0008-5472.22387235