Výsledky vyhledávání - "Martin K. Gelbard"

Akademický článek

Fibroproliferative disorders and diabetes: Understanding the pathophysiologic relationship between Peyronie’s disease, Dupuytren disease and diabetes

Autor: Martin K. Gelbard, Joel Rosenbloom

Publikováno v: Endocrinology, Diabetes & Metabolism, Vol 4, Iss 2, Pp n/a-n/a (2021)

Abstract Introduction Fibrosis is characterized by dysregulation and accumulation of extracellular matrix. Peyronie's disease and Dupuytren disease are fibroproliferative disorders of the tunica albuginea of the penis and fascia of the hand, respecti

Externí odkaz: https://doaj.org/article/cd5ac8f6f4914f67a8a302a164bbcb83

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Clinical Significance of Shortened Penile Length and Alterations in Penile Length Following Treatment for Peyronie's Disease

Autor: Irwin, Goldstein, Martin K, Gelbard, Larry I, Lipshultz

Publikováno v: Sexual Medicine Reviews. 10:409-420

Across many cultures, penis size has been associated with virility, and concerns about penile length are commonplace. Peyronie's disease (PD) is a known acquired cause of penile shortening.This paper describes the psychosocial impacts of penile lengt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cfbeb830a6efe487f4953b85d946bed
https://doi.org/10.1016/j.sxmr.2021.12.005

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Sixty years in the making: collagenase Clostridium histolyticum, from benchtop to FDA approval and beyond

Autor: Martin K. Gelbard, Steven A. Mills

Publikováno v: World Journal of Urology. 38:269-277

The introduction of collagenase Clostridium histolyticum (CCH) as the first and only FDA-approved non-surgical treatment for Peyronie’s disease (PD) has been an important step in its management. Our aim is to provide an overview of the historical o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd02d74ab16eaa4fb6aa89a89e10b96
https://doi.org/10.1007/s00345-019-02818-3

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Intralesional Collagenase Clostridium histolyticum Causes Meaningful Improvement in Men with Peyronie's Disease: Results of a Multi-Institutional Analysis

Autor: Martin K. Gelbard, Matthew Ziegelmann, Landon Trost, Wayne Jg Hellstrom, Laith Alzweri, Amanda S. J. Chung, Ramón Virasoro, Ashley Tapscott, Hoang Minh Tue Nguyen

Publikováno v: Journal of Urology. 201:777-782

In a multi-institutional setting we studied the efficacy and safety outcomes at multiple high volume centers where collagenase Clostridium histolyticum is used to treat Peyronie's disease.We collected retrospective data on consecutive patients with P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79841c04a1d2ff498616d5b27c611ba5
https://doi.org/10.1097/ju.0000000000000032

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Human Pharmacokinetics and Safety of Subcutaneous Collagenase Clostridium Histolyticum in Women

Autor: Ashish C, Bhatia, Michael P, McLane, Tony, Priestley, Saji, Vijayan, Martin K, Gelbard

Publikováno v: Journal of drugs in dermatology : JDD. 19(9)

Clostridium collagenase histolyticum (CCH) is being evaluated in women as a cellulite treatment.To report preclinical safety and human pharmacokinetics (PK) and safety data for CCH.Across 3 PK studies, 41 women received 12 subcutaneous injections per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0fa0b21f94174bb17137bd6883c39e6
https://pubmed.ncbi.nlm.nih.gov/33026751

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Long-term Curvature Deformity Characterization in Men Previously Treated With Collagenase Clostridium Histolyticum for Peyronie's Disease, Subgrouped by Penile Plaque Calcification

Autor: Yiqun Hu, Qinfang Xiang, Martin K. Gelbard, Henry R. Wolfe, Michael Mclane, Irwin Goldstein

Publikováno v: Urology. 146

Objective To examine the long-term (5-year) efficacy and safety of collagenase clostridium histolyticum (CCH) therapy in men with Peyronie's disease and varying degrees of plaque calcification. Materials and Methods CCH-treated adult men from the 12-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b929844d842c99c8dcb50e009281d6
https://pubmed.ncbi.nlm.nih.gov/32896582

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Safety and Efficacy of Collagenase Clostridium histolyticum in the Treatment of Acute Phase Peyronie's Disease: A Multi-institutional Analysis

Autor: Ramón Virasoro, Hoang Minh Tue Nguyen, Landon Trost, Ayad Yousif, Martin K. Gelbard, Matthew Ziegelmann, Amanda S. J. Chung, Wayne J.G. Hellstrom, Ashley H. Tapscott

Publikováno v: Urology. 145

Objective To study, in a multi-institutional setting, the efficacy/safety outcomes in acute phase Peyronie's disease (PD) of multiple high-volume centers employing CCH to treat PD, which is defined as the abnormal formation of fibrous plaque(s) in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5c0a3e68a1435f746812d00429c75a
https://pubmed.ncbi.nlm.nih.gov/32777367

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Long-Term Safety and Curvature Deformity Characterization in Patients Previously Treated with Collagenase clostridium Histolyticum for Peyronie's Disease

Autor: Michael McLane, Larry I. Lipshultz, Saji Vijayan, Genzhou Liu, Martin K. Gelbard, Yiqun Hu, Qinfang Xiang, Irwin Goldstein

Publikováno v: The Journal of urology. 203(6)

We assessed the long-term safety and immunogenicity profile of collagenase clostridium histolyticum and characterized penile curvature deformity over time in patients previously treated for Peyronie's disease.This phase 4 study included men who recei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f820c844363cd059c9cfbb3936c7886
https://pubmed.ncbi.nlm.nih.gov/32155370

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