Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Martin K Lotz"'
Autor:
Hannah Swahn, Jasmin Mertens, Merissa Olmer, Kevin Myers, Tony S. Mondala, Padmaja Natarajan, Steven R. Head, Oscar Alvarez‐Garcia, Martin K. Lotz
Publikováno v:
Advanced Science, Vol 11, Iss 17, Pp n/a-n/a (2024)
Abstract Elucidating how cell populations promote onset and progression of intervertebral disc degeneration (IDD) has the potential to enable more precise therapeutic targeting of cells and mechanisms. Single‐cell RNA‐sequencing (scRNA‐seq) is
Externí odkaz:
https://doaj.org/article/4784fdf5fbf64119b1051a99e8a6f039
Autor:
Manabu Kawata, Daniel B. McClatchy, Jolene K. Diedrich, Merissa Olmer, Kristen A. Johnson, John R. Yates, Martin K. Lotz
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
Osteoarthritis (OA) is the most common joint disorder, and disease-modifying OA drugs (DMOADs) represent a major need in OA management. Krüppel-like factor 4 (KLF4) is a central transcription factor upregulating regenerative and protective functions
Externí odkaz:
https://doaj.org/article/84f445dd7562469d8561ab051947bdb1
Autor:
Yohei Sanada, Yasunari Ikuta, Chenyang Ding, Masahiro Shinohara, Dilimulati Yimiti, Hiroyuki Ishitobi, Keita Nagira, Minjung Lee, Takayuki Akimoto, Sachi Shibata, Masakazu Ishikawa, Tomoyuki Nakasa, Kiminori Matsubara, Martin K. Lotz, Nobuo Adachi, Shigeru Miyaki
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-17 (2022)
Abstract Background Animal models of spontaneous osteoarthritis (OA) are sparse and not well characterized. The purpose of the present study is to examine OA-related changes and mechanisms in senescence-accelerated mouse prone 8 (SAMP8) that displays
Externí odkaz:
https://doaj.org/article/858d78eac3ea481294fd92a47106f8d7
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Objectives: RNA-binding proteins (RBPs) have diverse and essential biological functions, but their role in cartilage health and disease is largely unknown. The objectives of this study were (i) map the global landscape of RBPs expressed and enriched
Externí odkaz:
https://doaj.org/article/aea9b0852ae540f4b61ba5ac9ea09ad3
Autor:
Yusuke Fujiwara, Chenyang Ding, Yohei Sanada, Dilimulati Yimiti, Masakazu Ishikawa, Tomoyuki Nakasa, Naosuke Kamei, Kazunori Imaizumi, Martin K. Lotz, Takayuki Akimoto, Shigeru Miyaki, Nobuo Adachi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2023)
Osteoarthritis (OA), the most prevalent aging-related joint disease, is characterized by insufficient extracellular matrix synthesis and articular cartilage degradation and is caused by various risk factors including aging and traumatic injury. Most
Externí odkaz:
https://doaj.org/article/d12359d04f2849089895d50e27a71bbe
Autor:
Yoshiaki Ito, Tokio Matsuzaki, Fumiaki Ayabe, Sho Mokuda, Ryota Kurimoto, Takahide Matsushima, Yusuke Tabata, Maiko Inotsume, Hiroki Tsutsumi, Lin Liu, Masahiro Shinohara, Yoko Tanaka, Ryo Nakamichi, Keiichiro Nishida, Martin K. Lotz, Hiroshi Asahara
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Osteoarthritis is caused by an imbalance between extracellular matrix synthesis and degradation. Here, the authors show that both strands of microRNA-455, -5p and -3p, target HIF2α and regulate cartilage homeostasis, and show that overexpression of
Externí odkaz:
https://doaj.org/article/f8166b7edfce46f19f52746332d9254e
Autor:
Masakazu Toya, Yukio Akasaki, Takuya Sueishi, Ichiro Kurakazu, Masanari Kuwahara, Taisuke Uchida, Tomoaki Tsutsui, Hidetoshi Tsushima, Hisakata Yamada, Martin K. Lotz, Yasuharu Nakashima
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract G protein-coupled receptor kinase 5 (GRK5) regulates inflammatory responses via the nuclear factor-kappa B (NF-κB) pathway. This study investigated the functional involvement of GRK5 in the pathogenesis of inflammatory arthritis. Immunohist
Externí odkaz:
https://doaj.org/article/2638c7ea22824548af6160da54e5d45a
Autor:
Alice Courties, Merissa Olmer, Kevin Myers, Phillip Ordoukhanian, Steven R Head, Padmaja Natarajan, Francis Berenbaum, Jérémie Sellam, Martin K Lotz
Publikováno v:
Annals of the Rheumatic Diseases. 82:710-718
ObjectivesCHRFAM7A is a uniquely human fusion gene that functions as a dominant negative regulator of alpha 7 acetylcholine nicotinic receptor (α7nAChR) in vitro. This study determined the impact of CHRFAM7A on α7nAChR agonist responses, osteoarthr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9f3e7799ae585e85c3e6ce9eb087c01
https://doi.org/10.1136/ard-2022-223470
https://doi.org/10.1136/ard-2022-223470
Autor:
Kensuke Kataoka, Ryota Kurimoto, Hiroki Tsutsumi, Tomoki Chiba, Tomomi Kato, Kana Shishido, Mariko Kato, Yoshiaki Ito, Yuichiro Cho, Osamu Hoshi, Ayako Mimata, Yuriko Sakamaki, Ryo Nakamichi, Martin K. Lotz, Keiji Naruse, Hiroshi Asahara
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Tendons and ligaments are pivotal connective tissues that tightly connect muscle and bone. In this study, we developed a novel approach to generate tendon/ligament-like tissues with a hierarchical structure, by introducing the tendon/ligament-specifi
Externí odkaz:
https://doaj.org/article/20e44cb8d8ce4a15883916e45a651b9d
Autor:
Shouan Zhu, Huanhuan Liu, Trent Davis, Craig R.G. Willis, Reetobrata Basu, Luke Witzigreuter, Stephen Bell, Nathaniel Szewczyk, Martin K. Lotz, Marcheta Hill, Roberto J. Fajardo, Patrick M. O'Connor, Darlene E. Berryman, John J. Kopchick
Publikováno v:
Arthritis & Rheumatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9604342fe0a037a913ea12cb399e978c
https://doi.org/10.1002/art.42470
https://doi.org/10.1002/art.42470