Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Martin K Childers"'
Autor:
Aaron W James, Xinli Zhang, Mihaela Crisan, Winters R Hardy, Pei Liang, Carolyn A Meyers, Sonja Lobo, Venu Lagishetty, Martin K Childers, Greg Asatrian, Catherine Ding, Yu-Hsin Yen, Erin Zou, Kang Ting, Bruno Peault, Chia Soo
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177308 (2017)
For over 15 years, human subcutaneous adipose tissue has been recognized as a rich source of tissue resident mesenchymal stem/stromal cells (MSC). The isolation of perivascular progenitor cells from human adipose tissue by a cell sorting strategy was
Externí odkaz:
https://doaj.org/article/7f92defcf79f47299db51499cc6b947e
Autor:
Martin K Childers, Janet R Bogan, Daniel J Bogan, Hansel eGreiner, Melanie eHolder, Robert eGrange, Joe N Kornegay
Publikováno v:
Frontiers in Pharmacology, Vol 2 (2012)
Calpains likely play a role in the pathogenesis of Duchenne muscular dystrophy (DMD). Accordingly, calpain inhibition may provide therapeutic benefit to DMD patients. In the present study, we sought to measure benefit from administration of a novel c
Externí odkaz:
https://doaj.org/article/1a7baa2e340b44a8b4b8f6a6c8846663
Autor:
Edward L. LaGory, Colin Holbrook, Sang-Ging Ong, Chris Denning, Andrew H. Chang, John W. Day, Martin K. Childers, Alexandre J.S. Ribeiro, Honghui Wang, Alex C.Y. Chang, Gaspard Pardon, Joseph C. Wu, Kassie Koleckar, Sara Ancel, Helen M. Blau, David L. Mack, John Ramunas, Amato J. Giaccia, Asuka Eguchi, Haodi Wu, Beth L. Pruitt
Publikováno v:
Stem Cell Reports
Stem cell reports, vol 16, iss 9
Stem cell reports, vol 16, iss 9
Summary Duchenne muscular dystrophy (DMD) is a rare X-linked recessive disease that is associated with severe progressive muscle degeneration culminating in death due to cardiorespiratory failure. We previously observed an unexpected proliferation-in
Autor:
Corrado Poggesi, Chiara Tesi, Alice Ward Racca, Michael R. Hoopmann, Cecilia Ferrantini, J. Manuel Pioner, Lil Pabon, Jordan M. Klaiman, Veronica Muskheli, Michael Regnier, Xuan Guan, Martin K. Childers, Deok Ho Kim, David L. Mack, Charles E. Murry, Robert L. Moritz, Jesse Macadangdang
Publikováno v:
Cardiovasc Res
Aims Heart failure invariably affects patients with various forms of muscular dystrophy (MD), but the onset and molecular sequelae of altered structure and function resulting from full-length dystrophin (Dp427) deficiency in MD heart tissue are poorl
Autor:
Michael I. Lewis, Mark A. Aminzadeh, Allen M. Andres, Ronald A. Victor, Russell G. Rogers, Rachel E. Tobin, Joshua M. Goldhaber, Angelo G. Torrente, Roberta A. Gottlieb, Martin K. Childers, Mario Fournier, Xiangming Ding, Xuan Guan, David J. Taylor, Eduardo Marbán, Ahmed Ibrahim
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 10, Iss 3, Pp 942-955 (2018)
Stem cell reports, vol 10, iss 3
Stem Cell Reports, Vol 10, Iss 3, Pp 942-955 (2018)
Stem cell reports, vol 10, iss 3
Summary Genetic deficiency of dystrophin leads to disability and premature death in Duchenne muscular dystrophy (DMD), affecting the heart as well as skeletal muscle. Here, we report that clinical-stage cardiac progenitor cells, known as cardiosphere
Publikováno v:
Muscle Gene Therapy ISBN: 9783030030940
X-linked myotubular myopathy (XLMTM) emerges from mutations in the MTM1 gene and affects around 1 in 50,000 live-born male infants. This congenital myopathy has currently no treatment and leads to a severe impairment of motor skills and ventilation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f5ff573a93cfcde4a52cf046ef77575
https://doi.org/10.1007/978-3-030-03095-7_32
https://doi.org/10.1007/978-3-030-03095-7_32
Publikováno v:
Muscle Gene Therapy ISBN: 9783030030940
The histological and biochemical evaluation of muscle tissue can be of critical importance for the establishment of safety and efficacy in muscle gene therapy studies. While specific pathological and biochemical endpoints vary greatly with respect to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d920f292c8a58a2c1ef9ce9045dc9212
https://doi.org/10.1007/978-3-030-03095-7_12
https://doi.org/10.1007/978-3-030-03095-7_12
Autor:
David L. Mack, Jean-Baptiste Dupont, Ana Buj-Bello, Michael W. Lawlor, Robert W. Grange, John T. Gray, Jianjun Guo, Martin K. Childers
Multiple clinical trials employing recombinant adeno-associated viral (rAAV) vectors have been initiated for neuromuscular disorders, including Duchenne and limb-girdle muscular dystrophies, spinal muscular atrophy, and recently X-linked myotubular m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4005986ac78bc21c9d069085cd04e9ae
https://doi.org/10.1101/499384
https://doi.org/10.1101/499384
Autor:
Xuan Guan, Eunpyo Choi, Yak-Nam Wang, David L. Mack, Michael Regnier, Dayae Kim, Smith As, Leung W, Hannele Ruohola-Baker, Max R. Salick, Macadangdang, Martin K. Childers, Su-In Lee, Jason W. Miklas
Directed differentiation of human pluripotent stem cells (hPSCs) into cardiomyocytes typically produces cells with structural, functional, and biochemical properties that most closely resemble those present in the fetal heart. Here we establish an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad71fbe0da7b17f17b3e72039a88782
Autor:
Bradley P Morgan, Eva R. Chin, Martin K. Childers, SiWei Luo, Darren Hwee, Robert W. Grange, David L. Mack, Fady I. Malik, Jordan M. Klaiman
Publikováno v:
Neuromuscular Disorders. 30:S168