Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Martin K, Bayliss"'
Autor:
Paul D. Leeson, Martin K. Bayliss, Anthony J. Taylor, Paul L. Feldman, Palovich Michael R, James Butler, Darren V. S. Green
Publikováno v:
Drug discovery today. 21(10)
In an attempt to seek increased understanding of compound attributes that influence successful drug pipeline progression, GlaxoSmithKline's portfolio of oral candidates was compared with reference sets of marketed oral drugs. The approach differs fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c1d62bb595607a1cbf3d1b389ccb95
https://pubmed.ncbi.nlm.nih.gov/27423371
https://pubmed.ncbi.nlm.nih.gov/27423371
Autor:
Boris Kardziev, Michael Schmidt, Petra Högger, Chris D. Edwards, Martin K. Bayliss, Mirjam Gnadt, Beatrice Trammer
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 81:617-626
The aim of the present investigation was to compare the onset of action and intrinsic activity of the long-acting β 2 -agonist GW597901 with the fast- and short-acting salbutamol as model compounds using an isolated human lung reperfusion model. Twe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1232703e0de8218d81fde31bc2fae4b
https://doi.org/10.1016/j.ejpb.2012.04.013
https://doi.org/10.1016/j.ejpb.2012.04.013
Publikováno v:
British Journal of Clinical Pharmacology. 47:625-635
Aims To assess the utility of human hepatic microsomes for predicting in vivo intrinsic clearance (CLint ) via the use of four cytochrome P450 2C9 substrates: phenytoin, tolbutamide (S)-ibuprofen (two pathways) and diclofenac, and to examine the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73245e0c6a638aafaef315b45477b7df
https://doi.org/10.1046/j.1365-2125.1999.00935.x
https://doi.org/10.1046/j.1365-2125.1999.00935.x
Autor:
Mirjam, Gnadt, Beatrice, Trammer, Boris, Kardziev, Martin K, Bayliss, Chris D, Edwards, Michael, Schmidt, Petra, Högger
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 81(3)
The aim of the present investigation was to compare the onset of action and intrinsic activity of the long-acting β(2)-agonist GW597901 with the fast- and short-acting salbutamol as model compounds using an isolated human lung reperfusion model. Twe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f6127af39ccf389acc550a51fa1e0bb
https://pubmed.ncbi.nlm.nih.gov/22561952
https://pubmed.ncbi.nlm.nih.gov/22561952
Autor:
Beatrice Trammer, Michael Schmidt, Boris Kardziev, Mirjam Gnadt, Matthias Freiwald, Chris D. Edwards, Godehard Friedel, Petra Högger, Martin K. Bayliss
Publikováno v:
Pulmonary pharmacologytherapeutics. 25(1)
Background The aim of the present investigation was to compare the pulmonary absorption of the novel long-acting β 2 -agonist GW597901 with salbutamol and to determine the influence of an induced bronchoconstriction on the pharmacokinetics of the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef7c331c8aea935dc94fe81f4db00c1
https://pubmed.ncbi.nlm.nih.gov/22245488
https://pubmed.ncbi.nlm.nih.gov/22245488
Autor:
N. Lindsay, Graham Somers, C. Freathy, S. Ho, Martin K. Bayliss, B. M. Lowdon, Gary R. Manchee, Amanda Woodrooffe, A. E. Jones
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 35(10)
The pulmonary and hepatic expression and catalytic activities of phase I and II drug-metabolizing enzymes were compared using human lung and liver tissue, and lung parenchymal cells (LPCs) and cryopreserved hepatocytes. Cytochrome P450 gene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad19772029c1e56fa79ffd6ef24b2b5
https://pubmed.ncbi.nlm.nih.gov/17627976
https://pubmed.ncbi.nlm.nih.gov/17627976
Autor:
J. Brian Houston, Robert Edwards, Martin K Bayliss, ZE Barter, Brian G. Lake, Alan R. Boobis, Philip H Beaune, John C. Lipscomb, Geoffrey T. Tucker, David J. Carlile, Olavi Pelkonen, Amin Rostami-Hodjegan
Publikováno v:
Current drug metabolism. 8(1)
Reported predictions of human in vivo hepatic clearance from in vitro data have used a variety of values for the scaling factors human microsomal protein (MPPGL) and hepatocellularity (HPGL) per gram of liver, generally with no consideration of the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d4b56aaa066af222e19fa0b862492b
https://pubmed.ncbi.nlm.nih.gov/17266522
https://pubmed.ncbi.nlm.nih.gov/17266522
Autor:
Graham Somers, Martin K. Bayliss
The liver performs a wide range of physiologically important functions, including the synthesis and secretion of albumin, fibrinogen, and other plasma proteins; the synthesis of cholesterol and bile acids, and the metabolism of drugs, steroids, and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ab4adc67bd400e2fd2539b10d53b5b9
https://doi.org/10.1385/1-59259-861-7:249
https://doi.org/10.1385/1-59259-861-7:249
Autor:
Han van de Waterbeemd, Herbert Schneider, Jiunn Lin, Gerardine Burton, Andreas Reichel, Babu Subramanyam, Thierry Lavé, Ulf Boemer, Andreas Baumann, Arun Mandagere, Geert Mannens, Dennis A. Smith, Bjorn Wallmark, Timothy Olah, Nikolaus Heinrich, Thorsten Blume, Andrea Rotgeri, John Dixon, Thomas Steger-Hartmann, Joe Post, Martin K Bayliss, Gabriele Cruziani, Olavi Pelkonen, Christian Wienhold, Iris Pribilla, Ron Vergona, Gerd Fricker, Karsten Denner, Gerd Siemeister
Publikováno v:
Pharmacokinetic Challenges in Drug Discovery ISBN: 9783662043851
I have a few questions relating to your filtration or artificial membrane model. Could one explanation for your poor correlation with the Caco-2 data be that you use a different solvent concentration?
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8d06e0c46697eb28e1c88bc425efc6f
https://doi.org/10.1007/978-3-662-04383-7_13
https://doi.org/10.1007/978-3-662-04383-7_13