Zobrazeno 1 - 10
of 3 262
pro vyhledávání: '"Martin Jeffrey"'
Autor:
Angela Chong, James D. Foster, Wilfred Goldmann, Lorenzo Gonzalez, Martin Jeffrey, Matthew J. O’Connor, Keith Bishop, Ben C. Maddison, E. Fiona Houston, Kevin C. Gough, Nora Hunter
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract To understand the possible role of mixed-prion infections in disease presentation, the current study reports the co-infection of sheep with bovine spongiform encephalopathy (BSE) and scrapie. The bovine BSE agent was inoculated subcutaneousl
Externí odkaz:
https://doaj.org/article/8389f00c95af4eeab062820d78120c76
As Large Language Models (LLMs) are deployed and integrated into thousands of applications, the need for scalable evaluation of how models respond to adversarial attacks grows rapidly. However, LLM security is a moving target: models produce unpredic
Externí odkaz:
http://arxiv.org/abs/2406.11036
Autor:
Gillian McGovern, Stuart Martin, Martin Jeffrey, Glenda Dexter, Steve A C Hawkins, Sue J Bellworthy, Lisa Thurston, Lynne Algar, Lorenzo González
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151440 (2016)
The minimum dose required to cause infection of Romney and Suffolk sheep of the ARQ/ARQ or ARQ/ARR prion protein gene genotypes following oral inoculation with Romney or Suffolk a sheep Bovine spongiform encephalopathy (BSE)-derived or cattle BSE-der
Externí odkaz:
https://doaj.org/article/8a8c7ba9aa0749e0aa3aba4cb4bca8cc
Autor:
Michael Jones, Darren Wight, Rona Barron, Martin Jeffrey, Jean C. Manson, Christopher Prowse, James W. Ironside, Mark W. Head
Publikováno v:
Emerging Infectious Diseases, Vol 15, Iss 12, Pp 2013-2016 (2009)
To assess interspecies barriers to transmission of transmissible spongiform encephalopathies, we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 m
Externí odkaz:
https://doaj.org/article/9ab5598c1ac248f2a95b1d743374ca1d
Publikováno v:
PLoS Pathogens, Vol 11, Iss 7, p e1004958 (2015)
The prion hypothesis postulates that the infectious agent in transmissible spongiform encephalopathies (TSEs) is an unorthodox protein conformation based agent. Recent successes in generating mammalian prions in vitro with bacterially expressed recom
Externí odkaz:
https://doaj.org/article/31c7991a6228404eb76e7b1c1cda1cd1
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143251 (2015)
Sheep are natural hosts of the prion disease, scrapie. They are also susceptible to experimental challenge with various scrapie strains and with bovine spongiform encephalopathy (BSE), which affects cattle and has been accidentally transmitted to a r
Externí odkaz:
https://doaj.org/article/46d75f5605c2491eae49dc0a36d108fe
Autor:
Martin Jeffrey, Pedro Piccardo, Diane L Ritchie, James W Ironside, Alison J E Green, Gillian McGovern
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129499 (2015)
Many human neurodegenerative diseases are associated with hyperphosphorylation and widespread intra-neuronal and glial associated aggregation of the microtubule associated protein tau. In contrast, animal tauopathies are not reported with only senesc
Externí odkaz:
https://doaj.org/article/e0e775d0685e496f842a4f795037e8a6
Autor:
Mark P Dagleish, Stuart Martin, Philip Steele, Jeanie Finlayson, Samantha L Eaton, Sílvia Sisó, Paula Stewart, Natalia Fernández-Borges, Scott Hamilton, Yvonne Pang, Francesca Chianini, Hugh W Reid, Wilfred Goldmann, Lorenzo González, Joaquín Castilla, Martin Jeffrey
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116094 (2015)
European red deer (Cervus elaphus elaphus) are susceptible to the agent of bovine spongiform encephalopathy, one of the transmissible spongiform encephalopathies, when challenged intracerebrally but their susceptibility to alimentary challenge, the p
Externí odkaz:
https://doaj.org/article/d067c5cca9484733b44b5f252cfe36c0