Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Martin Jaburek"'
Autor:
Martin Jabůrek, Eduardo Klöppel, Pavla Průchová, Oleksandra Mozheitova, Jan Tauber, Hana Engstová, Petr Ježek
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103283- (2024)
We asked whether acute redox signaling from mitochondria exists concomitantly to fatty acid- (FA-) stimulated insulin secretion (FASIS) at low glucose by pancreatic β-cells. We show that FA β-oxidation produces superoxide/H2O2, providing: i) mitoch
Externí odkaz:
https://doaj.org/article/2c62519b300e44dfa58a44a1a60d3131
Autor:
Ason C. Y. Chiang, Jan Ježek, Peiqiang Mu, Ying Di, Anna Klucnika, Martin Jabůrek, Petr Ježek, Hansong Ma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Genetic screens have been used extensively to probe interactions between nuclear genes and their impact on phenotypes. Probing interactions between mitochondrial genes and their phenotypic outcome, however, has not been possible due to a lac
Externí odkaz:
https://doaj.org/article/535c6d0b32ad4ccfa77fbdd9ef88c699
Publikováno v:
Molecules, Vol 23, Iss 6, p 1483 (2018)
Fatty acid (FA)-stimulated insulin secretion (FASIS) is reviewed here in contrast to type 2 diabetes etiology, resulting from FA overload, oxidative stress, intermediate hyperinsulinemia, and inflammation, all converging into insulin resistance. Focu
Externí odkaz:
https://doaj.org/article/d85192515a484778875df07006d9ed76
Autor:
Elena A Malingriaux, Anne Rupprecht, Lars Gille, Olga Jovanovic, Petr Jezek, Martin Jaburek, Elena E Pohl
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77786 (2013)
The production of reactive oxygen species (ROS) in mitochondria is very sensitive to the proton motive force and may be decreased by mild uncoupling, mediated e.g. by mitochondrial uncoupling proteins (UCPs). UCPs were conversely hypothesized to be a
Externí odkaz:
https://doaj.org/article/73c5601a52bc489dafef0f5e07e71a33
Publikováno v:
Free Radical Biology and Medicine. 192:82-83
Publikováno v:
Free Radical Biology and Medicine. 192:81-82
Publikováno v:
Free Radical Biology and Medicine. 192:91
Publikováno v:
Free Radical Biology and Medicine. 145:S87-S88
Publikováno v:
Free Radical Biology and Medicine. 145:S88
Publikováno v:
Free Radical Biology and Medicine. 112:152-153
Calcium-independent phospholipases (iPLA2s) are a family of enzymes participating in cellular signaling by simultaneously producing free fatty acids and lysophospholipids. Phospholipase iPLA2γ (PNPLA8) is targeted to mitochondria and has been shown