Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Martin J. Simard"'
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Extravasation of circulating cancer cells determines their metastatic potential. This process is initiated by the adhesion of cancer cells to vascular endothelial cells through specific interactions between endothelial adhesion receptors suc
Externí odkaz:
https://doaj.org/article/f2e4ef41a8f84b8cad6220c1adb09894
Autor:
Catherine Roy-Bellavance, Jennifer M. Grants, Stéphanie Miard, Kayoung Lee, Évelyne Rondeau, Chantal Guillemette, Martin J. Simard, Stefan Taubert, Frédéric Picard
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 8, Pp 2739-2747 (2017)
Despite many advances, the molecular links between energy metabolism and longevity are not well understood. Here, we have used the nematode model Caenorhabditis elegans to study the role of the yet-uncharacterized gene R148.3 in fat accumulation and
Externí odkaz:
https://doaj.org/article/92f17895ea9f4fe3aaecad620ce358ad
Autor:
Anisha Pal, Vaishnav Vasudevan, François Houle, Michael Lantin, Katherine A. Maniates, Miguel Quévillon Huberdeau, Allison L. Abbott, Martin J. Simard
Publikováno v:
bioRxiv
microRNAs regulate gene expression through interaction with an Argonaute protein family member. While some members of this protein family retain an enzymatic activity capable of cleaving RNA molecules complementary to Argonaute-bound small RNAs, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efb46c33862f938c5deee9dbe0d6e31
https://doi.org/10.1101/2023.01.19.524781
https://doi.org/10.1101/2023.01.19.524781
Publikováno v:
Journal of Biogeography. 48:2742-2754
Autor:
Benjamin Goyer, Martin J. Simard, Louis-Mathieu Harvey, Lucie Germain, François Houle, Pavan Kumar Kakumani, Tanit Guitart, Fátima Gebauer
Publikováno v:
Oncogene. 40:3231-3244
MicroRNAs and RNA-binding proteins (RBPs) primarily target the 3' UTR of mRNAs to control their translation and stability. However, their co-regulatory effects on specific mRNAs in physiology and disease are yet to be fully explored. CSDE1 is an RBP
Autor:
Guillaume Jannot, Pascale Michaud, Miguel Quévillon Huberdeau, Louis Morel-Berryman, James A Brackbill, Sandra Piquet, Katherine McJunkin, Kotaro Nakanishi, Martin J Simard
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006534 (2016)
[This corrects the article DOI: 10.1371/journal.pgen.1006484.].
Externí odkaz:
https://doaj.org/article/f558e6522c3741bea09bccd2bf1c0da4
Publikováno v:
Wiley interdisciplinary reviews. RNAREFERENCES. 13(4)
Among the different types of small RNAs, microRNAs (miRNAs) are key players in controlling gene expression at the mRNA level. To be active, they must associate with an Argonaute protein to form the miRNA induced silencing complex (miRISC) and binds t
Autor:
Miguel Quévillon Huberdeau, Vivek Nilesh Shah, Smita Nahar, Julia Neumeier, François Houle, Astrid Bruckmann, Foivos Gypas, Kotaro Nakanishi, Helge Großhans, Gunter Meister, Martin J. Simard
Publikováno v:
Cell Reports. 41:111822
Argonaute proteins are at the core of the microRNA-mediated gene silencing pathway essential for animals. In C. elegans, the microRNA-specific Argonautes ALG-1 and ALG-2 regulate multiple processes required for proper animal developmental timing and
Publikováno v:
PLoS Genetics, Vol 10, Iss 4, p e1004286 (2014)
microRNAs function in diverse developmental and physiological processes by regulating target gene expression at the post-transcriptional level. ALG-1 is one of two Caenorhabditis elegans Argonautes (ALG-1 and ALG-2) that together are essential for mi
Externí odkaz:
https://doaj.org/article/b5a9b49db15e4bfbb582fb2b5d87776c
Autor:
Alejandro Vasquez-Rifo, Gabriel D Bossé, Evelyne L Rondeau, Guillaume Jannot, Alexandra Dallaire, Martin J Simard
Publikováno v:
PLoS Genetics, Vol 9, Iss 11, p e1003961 (2013)
Many core components of the microRNA pathway have been elucidated and knowledge of their mechanisms of action actively progresses. In contrast, factors with modulatory roles on the pathway are just starting to become known and understood. Using a gen
Externí odkaz:
https://doaj.org/article/d2d781eb8e2047f1879855dc8601dc8e