Výsledky vyhledávání - "Martin J. Parratt"

Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping

Autor: Philip Stephen Jackson, Douglas S. Williamson, Martin J. Drysdale, Claire L. Nunns, Roderick E. Hubbard, Rob Howes, Harry Finch, Peter Kierstan, Martin J. Parratt, Jonathan D. Moore, Allan E. Surgenor, Heather Simmonite, Christopher J. Torrance, Georg Lentzen, Christine M. Richardson, Jenifer Borgognoni, Pawel Dokurno, James Brooke Murray

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 17:3880-3885

Virtual screening against a pCDK2/cyclin A crystal structure led to the identification of a potent and novel CDK2 inhibitor, which exhibited an unusual mode of interaction with the kinase binding motif. With the aid of X-ray crystallography and model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37faf19ad28ffd497210c055af377931
https://doi.org/10.1016/j.bmcl.2007.04.110

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Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: Protein structure-guided design and SAR

Autor: Allan E. Surgenor, James B. Murray, Alan Robertson, Martin J. Parratt, Andrew Cansfield, Christopher J. Torrance, Pawel Dokurno, Jenifer Borgognoni, Jonathan D. Moore, Christine M. Richardson, Douglas S. Williamson, Geraint L. Francis, Rob Howes

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 16:1353-1357

Crystallographic and modelling data, in conjunction with a medicinal chemistry template-hopping approach, led to the identification of a series of novel and potent inhibitors of human cyclin-dependent kinase 2 (CDK2), with selectivity over glycogen s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8791b75976dde63e4b7c70c5070ca38e
https://doi.org/10.1016/j.bmcl.2005.11.048

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Drug-like Annotation and Duplicate Analysis of a 23-Supplier Chemical Database Totalling 2.7 Million Compounds

Autor: Richard T. Baker, Stephen D. Roughley, Roderick E. Hubbard, Chen I-Jen, Christine M. Richardson, Allan M. Jordan, Andrew Potter, P. Greaney, Nicolas Foloppe, D. Morley, Martin J. Parratt, Nicolas Baurin

Publikováno v: Scopus-Elsevier

We have implemented five drug-like filters, based on 1D and 2D molecular descriptors, and applied them to characterize the drug-like properties of commercially available chemical compounds. In addition to previously published filters (Lipinski and Ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db83664490d8947c69d4e5889300c4b3
https://doi.org/10.1021/ci034260m

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Inhibition of HSV-1 protease by benzoxazinones

Autor: Joselina G. Gorniak, Martin J. Parratt, Richard L. Jarvest, James E. Strickler, Christine Debouck, Halina T. Serafinowska, L.John Jennings

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:2463-2466

Benzoxazinones have been discovered which are mechanism based inhibitors of HSV-1 protease with micromolar IC 50 values. Formation of a monoadduct consistent with the acyl-enzyme complex was detected by mass spectroscopy. A parallel array synthesis w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5046118ea710318122b9e163761afb9
https://doi.org/10.1016/0960-894x(96)00455-6

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A Direct Approach to the Synthesis of Famciclovir and Penciclovir

Autor: Steven O'Donnell, Bernadette M. Choudary, J. Robert, Martin J. Parratt, Johnson Graham, David W. Tudor, Graham Richard Geen, M. Dales, Peter M. Kincey, Neil Woods

Publikováno v: Nucleosides and Nucleotides. 15:981-994

Reaction of 2-amino-6-chloropurine with triethyl 3-bromopropane-1,1,1-tricarboxylate followed by decarbethoxylation/transesterification of the unpurified product was the key sequence in synthesising both the anti-herpesvirus agent penciclovir and its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ad2e966aeba6ecbdab62f82390f1c54
https://doi.org/10.1080/07328319608002029

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Influence of Remote Structure Upon Regioselectivity in the N-Alkylation of 2-Amino-6-Chloropurine: Application to the Synthesis of Penciclovir

Autor: Trevor John Grinter, Graham R. Geen, Martin J. Parratt, Bernadette M. Choudary, Fiona S. MacBeath

Publikováno v: Nucleosides and Nucleotides. 13:979-996

Reaction of 2-amino-6-chloropurine with trans-2-alkyl-5-iodoethyl-1,3-dioxanes under basic conditions afforded N-9 and N-7 alkylated products, the product ratio obtained being dependent on the size of the 2-alkyl group. This allowed a highly regiosel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1efeecf842fb19028e1b94561b371cb7
https://doi.org/10.1080/15257779408011871

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Completely diastereoselective aziridination of α,β-unsaturated acids via intramolecular reaction of 3-acetoxyaminoquinazolin-4(3H)-ones

Autor: Tony M. Raynham, Richard D Draycott, Martin J Parratt, David J Hirst, Robert S. Atkinson

Publikováno v: Tetrahedron Letters. 43:2083-2085

(R)-3-Amino-2-[1-(2-hydroxyethoxy)ethyl]quinazolin-4(3H)-one 10 was prepared in 62% yield without the need for chromatography and O-cinnamoylated; reaction with lead tetra-acetate gave aziridine 12 as a single diastereoisomer in quantitative yield wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90acdf6e415ea8224028a65a2195778d
https://doi.org/10.1016/s0040-4039(02)00136-3

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Synthesis and antiviral activity of 9-(phosphonoalkylnyloxy)purines: Novel acyclonucleotides

Autor: Martin J. Parratt, L.John Jennings

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:2611-2614

9-(3-Phosphonoprop-2-ynyloxy)adenine ( 5 ) and -guanine ( 6 ) were synthesised and found to have anti-herpesvirus actity. Attempted Arbusov reaction of a chloroalkyne ( 17 ) with triethyl phosphite unexpectedly gave the ( Z )-2-chloroalkenylphosphona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::841af1a4ebe0f69d80069c6dc153c13a
https://doi.org/10.1016/s0960-894x(01)80725-3

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ChemInform Abstract: Synthesis of (3-(Phosphonomethoxy)pyrrolidin-1-yl) Derivatives of Pyrimidines and Purines: Analogues of 2′,3′-Dideoxynucleotides

Autor: Martin J. Parratt, Richard L. Jarvest, Michael Raymond Harnden

Publikováno v: ChemInform. 24

Pyrrolidin-1-yl derivatives of pyrimidines and purines, incorporating the phosphonomethoxy group as a phosphate mimic, were prepared as analogues of 2′,3′-dideoxynucleotides. The heterocyclic bases uracil, thymine, cytosine, adenine and hypoxanth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4aa903971044ca83a5cd75f5e249a1d9
https://doi.org/10.1002/chin.199301266

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ChemInform Abstract: Novel Acyclonucleotides: Synthesis and Antiviral Activity of Alkenylphosphonic Acid Derivatives of Purines and a Pyrimidine

Autor: Robert M. Perkins, Martin J. Parratt, Michael Raymond Harnden, Ann Parkin

Publikováno v: ChemInform. 25

A series of phosphonoalkenyl and (phosphonoalkenyl)oxy derivatives of purines and a pyrimidine were synthesized. These compounds are the first reported acyclonucleotides which incorporate the alpha,beta-unsaturated phosphonic acid moiety as the phosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::602c0744798c1ac9d1e61e2aee03a9db
https://doi.org/10.1002/chin.199410192

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