Zobrazeno 1 - 10 of 34 pro vyhledávání: '"Martin J. McPhillie"'
1
Akademický článek
Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV
Autor: Scott Grossman, Colin W. G. Fishwick, Martin J. McPhillie
Publikováno v: Pharmaceuticals, Vol 16, Iss 2, p 261 (2023)
Increases in antibiotic usage and antimicrobial resistance occurrence have caused a dramatic reduction in the effectiveness of many frontline antimicrobial treatments. Topoisomerase inhibitors including fluoroquinolones are broad-spectrum antibiotics
Externí odkaz: https://doaj.org/article/6a1c882b99af4b1894a0f881f858331d
Zobrazit plný text záznamu
2
Akademický článek
Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites
Autor: Martin J. McPhillie, Ying Zhou, Mark R. Hickman, James A. Gordon, Christopher R. Weber, Qigui Li, Patty J. Lee, Kangsa Amporndanai, Rachel M. Johnson, Heather Darby, Stuart Woods, Zhu-hong Li, Richard S. Priestley, Kurt D. Ristroph, Scott B. Biering, Kamal El Bissati, Seungmin Hwang, Farida Esaa Hakim, Sarah M. Dovgin, Joseph D. Lykins, Lucy Roberts, Kerrie Hargrave, Hua Cong, Anthony P. Sinai, Stephen P. Muench, Jitender P. Dubey, Robert K. Prud'homme, Hernan A. Lorenzi, Giancarlo A. Biagini, Silvia N. Moreno, Craig W. Roberts, Svetlana V. Antonyuk, Colin W. G. Fishwick, Rima McLeod
Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Apicomplexan infections cause substantial morbidity and mortality, worldwide. New, improved therapies are needed. Herein, we create a next generation anti-apicomplexan lead compound, JAG21, a tetrahydroquinolone, with increased sp3-character to impro
Externí odkaz: https://doaj.org/article/2c4f99fc24ed49b8a965b629b176459d
Zobrazit plný text záznamu
3
Akademický článek
Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations
Autor: Kamal El Bissati, Henry Redel, Li-Min Ting, Joseph D. Lykins, Martin J. McPhillie, Rajendra Upadhya, Patrick M. Woster, Nigel Yarlett, Kami Kim, Louis M. Weiss
Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Twenty-two compounds belonging to several classes of polyamine analogs have been examined for their ability to inhibit the growth of the human malaria parasite Plasmodium falciparum in vitro and in vivo. Four lead compounds from the thiourea sub-seri
Externí odkaz: https://doaj.org/article/ef4b5cffc7f242ea9db0685ae8654b83
Zobrazit plný text záznamu
4
Akademický článek
CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii
Autor: Joseph D. Lykins, Ekaterina V. Filippova, Andrei S. Halavaty, George Minasov, Ying Zhou, Ievgeniia Dubrovska, Kristin J. Flores, Ludmilla A. Shuvalova, Jiapeng Ruan, Kamal El Bissati, Sarah Dovgin, Craig W. Roberts, Stuart Woods, Jon D. Moulton, Hong Moulton, Martin J. McPhillie, Stephen P. Muench, Colin W. G. Fishwick, Elisabetta Sabini, Dhanasekaran Shanmugam, David S. Roos, Rima McLeod, Wayne F. Anderson, Huân M. Ngô
Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Toxoplasma gondii, an Apicomplexan parasite, causes significant morbidity and mortality, including severe disease in immunocompromised hosts and devastating congenital disease, with no effective treatment for the bradyzoite stage. To address this, we
Externí odkaz: https://doaj.org/article/7419bf5aa70142e9901dc7a9d33f4a08
Zobrazit plný text záznamu
6
SAR investigation and optimization of benzimidazole-based derivatives as antimicrobial agents against Gram-negative bacteria
Autor: Eman M.E. Dokla, Nader S. Abutaleb, Sandra N. Milik, Ezzat A.E.A. Kandil, Omar M. Qassem, Yehia Elgammal, Maha Nasr, Martin J. McPhillie, Khaled A.M. Abouzid, Mohamed N. Seleem, Peter Imming, Mai Adel
Publikováno v: European journal of medicinal chemistry. 247
Antibiotic-resistant bacteria represent a serious threat to modern medicine and human life. Only a minority of antibacterial agents are active against Gram-negative bacteria. Hence, the development of novel antimicrobial agents will always be a vital
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba4a1ec611a52d7fd16faa8aef904fd
https://pubmed.ncbi.nlm.nih.gov/36584632
Zobrazit plný text záznamu
8
1,4-Diazepines
Autor: Martin J. McPhillie, Andrew N. Boa
Publikováno v: Comprehensive Heterocyclic Chemistry IV ISBN: 9780128186565
Comprehensive Heterocyclic Chemistry IV
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d387475e6373ee2292305d2148808d3a
https://doi.org/10.1016/b978-0-12-818655-8.00110-4
Zobrazit plný text záznamu
9
De Novo Design of Type II Topoisomerase Inhibitors as Potential Antimicrobial Agents Targeting a Novel Binding Region
Autor: Kyle M. Orritt, Lauren Abbott, Thomas Germe, Colin W. G. Fishwick, Anthony Maxwell, Juliette Newell, Holly Jackson, Martin J. McPhillie, Benjamin Bury
By 2050 it is predicted that antimicrobial resistance will be responsible for 10 million global deaths annually, costing the world economy $100 trillion. Clearly, strategies to address this problem are required as bacterial evolution is rendering our
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67370c43bc395e9e07b0a1805633b0e
https://doi.org/10.26434/chemrxiv-2021-290nh-v2
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje