Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Martin J. Loessner"'
Autor:
Jiemin Du, Susanne Meile, Jasmin Baggenstos, Tobias Jäggi, Pietro Piffaretti, Laura Hunold, Cassandra I. Matter, Lorenz Leitner, Thomas M. Kessler, Martin J. Loessner, Samuel Kilcher, Matthew Dunne
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Bacteriophages operate via pathogen-specific mechanisms of action distinct from conventional, broad-spectrum antibiotics and are emerging as promising alternative antimicrobials. However, phage-mediated killing is often limited by bacterial
Externí odkaz:
https://doaj.org/article/15efe631889b4075b2703227b046234f
Autor:
Susanne Meile, Jiemin Du, Samuel Staubli, Sebastian Grossmann, Hendrik Koliwer-Brandl, Pietro Piffaretti, Lorenz Leitner, Cassandra I. Matter, Jasmin Baggenstos, Laura Hunold, Sonja Milek, Christian Guebeli, Marko Kozomara-Hocke, Vera Neumeier, Angela Botteon, Jochen Klumpp, Jonas Marschall, Shawna McCallin, Reinhard Zbinden, Thomas M. Kessler, Martin J. Loessner, Matthew Dunne, Samuel Kilcher
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The rapid detection and species-level differentiation of bacterial pathogens facilitates antibiotic stewardship and improves disease management. Here, we develop a rapid bacteriophage-based diagnostic assay to detect the most prevalent patho
Externí odkaz:
https://doaj.org/article/380bf3f0f3d44554830c4469d686c355
Autor:
Anja P. Keller, Markus Huemer, Chun-Chi Chang, Srikanth Mairpady Shambat, Caroline Bjurnemark, Nicole Oberortner, Michaela V. Santschi, Léa V. Zinsli, Christian Röhrig, Anna M. Sobieraj, Yang Shen, Fritz Eichenseher, Annelies S. Zinkernagel, Martin J. Loessner, Mathias Schmelcher
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT The current standard of treatment for chronic staphylococcal osteomyelitis entails high doses of antibiotics over the course of several weeks. Biofilm-associated and intracellular persisters are key factors contributing to therapeutic failur
Externí odkaz:
https://doaj.org/article/6260294adfd2410d95328a1b7ada479c
Autor:
Maik Müller, Fabienne Gräbnitz, Niculò Barandun, Yang Shen, Fabian Wendt, Sebastian N. Steiner, Yannik Severin, Stefan U. Vetterli, Milon Mondal, James R. Prudent, Raphael Hofmann, Marc van Oostrum, Roman C. Sarott, Alexey I. Nesvizhskii, Erick M. Carreira, Jeffrey W. Bode, Berend Snijder, John A. Robinson, Martin J. Loessner, Annette Oxenius, Bernd Wollscheid
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The spatial organization of cell surface receptors is critical for cell signaling and drug action. Here, the authors develop an optoproteomic method for mapping surface protein interactions, revealing cellular responses to antibodies, drugs and viral
Externí odkaz:
https://doaj.org/article/07e4f618935147f798b726c0fe3eb3c4
Autor:
Pauline C. Göller, Tabea Elsener, Dominic Lorgé, Natasa Radulovic, Viona Bernardi, Annika Naumann, Nesrine Amri, Ekaterina Khatchatourova, Felipe Hernandes Coutinho, Martin J. Loessner, Elena Gómez-Sanz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The host range of bacteriophages defines their impact on bacterial ecology and diversity. Here, Göller et al. isolate 94 staphylococcal phages from wastewater and determine their host range on 117 staphylococci from 29 species, revealing a predomina
Externí odkaz:
https://doaj.org/article/f85c4158faa744e79926f9e5bcacf88b
Autor:
Leandra E. Knecht, Yannick Born, Cosima Pelludat, Joël F. Pothier, Theo H. M. Smits, Martin J. Loessner, Lars Fieseler
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Broad application of antibiotics gave rise to increasing numbers of antibiotic resistant bacteria. Therefore, effective alternatives are currently investigated. Bacteriophages, natural predators of bacteria, could work as such an alternative. Althoug
Externí odkaz:
https://doaj.org/article/fa0fba71866546408a67b2f915f06b8e
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Listeria monocytogenes is an opportunistic intracellular pathogen causing an infection termed listeriosis. Despite the low incidence of listeriosis, the high mortality rate in individuals at risk makes this bacterium one of the most dangerous foodbor
Externí odkaz:
https://doaj.org/article/e026393dfd7f430694b763c806dcbd5b
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 315-329 (2021)
Biotherapeutics, and antimicrobial proteins in particular, are of increasing interest for human medicine. An important challenge in the development of such therapeutics is their potential immunogenicity, which can induce production of anti-drug-antib
Externí odkaz:
https://doaj.org/article/4d36e4e506474904ac1fb8c9c1532c21
Autor:
Sander Witte, Léa V. Zinsli, Rafael Gonzalez-Serrano, Cassandra I. Matter, Martin J. Loessner, Joël T. van Mierlo, Matthew Dunne
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3416-3426 (2021)
Bacteriophages (phages) are widely used as biocontrol agents in food and as antibacterial agents for treatment of food production plant surfaces. An important feature of such phages is broad infectivity towards a given pathogenic species. Phages atta
Externí odkaz:
https://doaj.org/article/0d460deadad146a8976b394faba486b0
Autor:
Pauline C. Göller, Jose M. Haro-Moreno, Francisco Rodriguez-Valera, Martin J. Loessner, Elena Gómez-Sanz
Publikováno v:
Microbiome, Vol 8, Iss 1, Pp 1-16 (2020)
Abstract Background Bacteriophages (phages) are the most numerous biological entities on Earth and play a crucial role in shaping microbial communities. Investigating the bacteriophage community from soil will shed light not only on the yet largely u
Externí odkaz:
https://doaj.org/article/ffd6d98ea7a14137b33efd4a82157741