Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Martin J. Boulanger"'
Autor:
Sean Yanik, Varsha Venkatesh, Michelle L. Parker, Raghavendran Ramaswamy, Ababacar Diouf, Deepti Sarkar, Kazutoyo Miura, Carole A. Long, Martin J. Boulanger, Prakash Srinivasan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Invasion of human erythrocytes by Plasmodium falciparum (Pf) merozoites relies on the interaction between two parasite proteins: apical membrane antigen 1 (AMA1) and rhoptry neck protein 2 (RON2). While antibodies to AMA1 provide limited pro
Externí odkaz:
https://doaj.org/article/9187528e96e24a5396c3a092c3c046b1
Autor:
Florian Heinkel, Meghan M. Verstraete, Siran Cao, Janessa Li, Patrick Farber, Elizabeth Stangle, Begonia Silva-Moreno, Fangni Peng, Surjit Dixit, Martin J. Boulanger, Thomas Spreter Von Kreudenstein, Eric Escobar-Cabrera
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Immunoglobulin G (IgG) has served as a traditional framework for antibody-based biology, and engineering approaches for creating multispecific therapeutics have greatly expanded its applicability. Despite these developments, there are limits to the f
Externí odkaz:
https://doaj.org/article/3ff0d51cf58546558f21c46d25e34435
Autor:
Simon Houston, Ethan Schovanek, Kate M. E. Conway, Sarah Mustafa, Alloysius Gomez, Raghavendran Ramaswamy, Ayman Haimour, Martin J. Boulanger, Lisa A. Reynolds, Caroline E. Cameron
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The etiological agent of syphilis, Treponema pallidum ssp. pallidum, is a highly invasive “stealth” pathogen that can evade the host immune response and persist within the host for decades. This obligate human pathogen is adept at establishing in
Externí odkaz:
https://doaj.org/article/6d731f08041b463f9a7832f694f354d6
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4 (2022)
Fatty acid–and retinol-binding proteins (FARs) belong to a unique family of excreted/secreted proteins (ESPs) found exclusively in nematodes. Much of our understanding of these proteins, however, is limited to their in vitro binding characteristics
Externí odkaz:
https://doaj.org/article/f71852d8971745b896c645a767834062
Autor:
Sophia C. Parks, Susan Nguyen, Shyon Nasrolahi, Chaitra Bhat, Damian Juncaj, Dihong Lu, Raghavendran Ramaswamy, Harpal Dhillon, Hideji Fujiwara, Anna Buchman, Omar S. Akbari, Naoki Yamanaka, Martin J. Boulanger, Adler R. Dillman
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
Parasitic nematodes cause significant morbidity and mortality globally. Excretory/secretory products (ESPs) such as fatty acid- and retinol- binding proteins (FARs) are hypothesized to suppress host immunity during nematode infection, yet little is k
Externí odkaz:
https://doaj.org/article/7f9dfce116564f459e99b8e22eb3390e
Autor:
Catherine Suarez, Gaëlle Lentini, Raghavendran Ramaswamy, Marjorie Maynadier, Eleonora Aquilini, Laurence Berry-Sterkers, Michael Cipriano, Allan L. Chen, Peter Bradley, Boris Striepen, Martin J. Boulanger, Maryse Lebrun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Plasmodium and Toxoplasma parasites rely on rhoptry exocytosis for invasion, but the underlying mechanism is not known. Here, Suarez et al. characterize rhoptry apical surface proteins (RASP) that localize to the rhoptry cap and bind charged lipids,
Externí odkaz:
https://doaj.org/article/5d7eb981430d428a86981e90c449cc6b
Autor:
Meredith L. Jenkins, Jean Piero Margaria, Jordan T. B. Stariha, Reece M. Hoffmann, Jacob A. McPhail, David J. Hamelin, Martin J. Boulanger, Emilio Hirsch, John E. Burke
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Rab11 GTPases are involved in various cellular processes but their activation by guanine nucleotide exchange factors (GEFs) is not fully understood. Here, the authors present a structural and biochemical analysis of Rab11 bound to the GEF SH3BP5, pro
Externí odkaz:
https://doaj.org/article/195d660c5d9c4b958c577bebd6f5b073
Autor:
Felice D. Kelly, Brian M. Wei, Alicja M. Cygan, Michelle L. Parker, Martin J. Boulanger, John C. Boothroyd
Publikováno v:
mSphere, Vol 2, Iss 3 (2017)
ABSTRACT Many diverse intracellular pathogens, such as Legionella pneumophila, Chlamydia psittaci, Encephalitozoon sp., and Toxoplasma gondii, manipulate and relocate host cell organelles, including mitochondria. Toxoplasma tachyzoites use a secreted
Externí odkaz:
https://doaj.org/article/e04856649aa34bbc865a6614bc11f382
Autor:
Tomasz Blazejewski, Nirvana Nursimulu, Viviana Pszenny, Sriveny Dangoudoubiyam, Sivaranjani Namasivayam, Melissa A. Chiasson, Kyle Chessman, Michelle Tonkin, Lakshmipuram S. Swapna, Stacy S. Hung, Joshua Bridgers, Stacy M. Ricklefs, Martin J. Boulanger, Jitender P. Dubey, Stephen F. Porcella, Jessica C. Kissinger, Daniel K. Howe, Michael E. Grigg, John Parkinson
Publikováno v:
mBio, Vol 6, Iss 1 (2015)
ABSTRACT Sarcocystis neurona is a member of the coccidia, a clade of single-celled parasites of medical and veterinary importance including Eimeria, Sarcocystis, Neospora, and Toxoplasma. Unlike Eimeria, a single-host enteric pathogen, Sarcocystis, N
Externí odkaz:
https://doaj.org/article/1b21fff66b5144da8b40c3091910cd88
Autor:
James D. Wasmuth, Viviana Pszenny, Simon Haile, Emily M. Jansen, Alexandra T. Gast, Alan Sher, Jon P. Boyle, Martin J. Boulanger, John Parkinson, Michael E. Grigg
Publikováno v:
mBio, Vol 3, Iss 6 (2012)
ABSTRACT The Toxoplasma gondii SRS gene superfamily is structurally related to SRS29B (formerly SAG1), a surface adhesin that binds host cells and stimulates host immunity. Comparative genomic analyses of three Toxoplasma strains identified 182 SRS g
Externí odkaz:
https://doaj.org/article/29c657891aca450c82653a06a7d1225a