Výsledky vyhledávání - "Martin J Slater"

F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase

Autor: Martin J. Slater, Graham Edward Morris Sibley, Jason David Oliver, Laura McEntee, Nathan P. Wiederhold, Nicola Beckmann, Katharine S. Dobb, Michael Bromley, Anthony J. Kennedy, Joanne Livermore, Saskia du Pré, William W. Hope, Mike Birch, Derek Law

Publikováno v: Oliver, J D, Sibley, G E M, Beckmann, N, Dobb, K S, Slater, M J, McEntee, L, Du Pre, S, Livermore, J, Bromley, M, Wiederhold, N P, Hope, W W, Kennedy, A J, Law, D & Birch, M 2016, ' F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase ', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 45, pp. 12809–12814 . https://doi.org/10.1073/pnas.1608304113
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

There is an important medical need for new antifungal agents with novel mechanisms of action to treat the increasing number of patients with life-threatening systemic fungal disease and to overcome the growing problem of resistance to current therapi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb38951d6bd7f059c30f0b5a34337ce
https://www.research.manchester.ac.uk/portal/en/publications/f901318-represents-a-novel-class-of-antifungal-drug-that-inhibits-dihydroorotate-dehydrogenase(9cb751b0-e1f3-483a-8bda-db1263b306cc).html

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XYZH systems as potential 1,3-dipoles. Part 62: 1,3-Dipolar cycloaddition reactions of metallo-azomethine ylides derived from α-iminophosphonates

Autor: Ronald Grigg, Yaşar Dürüst, Martin J. Slater, Mohammed A. B. Sarker, H. Ali Dondas

Publikováno v: Tetrahedron. 61:10667-10682

Metallo-azomethine ylides, generated from iminophosphonates in combination with LiBr or AgOAc and bases Et3N, DBU, t-butyl tetramethylguanidine(BTMG) undergo cycloaddition to give dialkyl pyrrolidine-2-phosphonates along with the corresponding Michae

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c56913a121bed53f0d21dc24987e7eb
https://doi.org/10.1016/j.tet.2005.08.079

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A formal asymmetric synthesis of both enantiomers of the Erythrina alkaloid 3-demethoxyerythratidinone

Autor: William P. Martin, Guy B. Streetley, Martin J. Slater, Steven M. Allin, Stella L. James

Publikováno v: Tetrahedron Letters. 45:5493-5496

A formal asymmetric synthesis of both enantiomers of the Erythrina alkaloid 3-demethoxyerythratidinone is reported through the application of a highly functionalised lactam template as an N-acyliminium precursor.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::454286a4afa15a1c71bbfc31ea067603
https://doi.org/10.1016/j.tetlet.2004.05.060

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Pyrrolidine-5,5-trans-lactams. 5. Pharmacokinetic Optimization of Inhibitors of Hepatitis C Virus NS3/4A Protease

Autor: and Martin J. Slater, J. Ed Robinson, Martin R. Johnson, Gail Mills, S. Lucy Hind, Tony J. Pateman, Tracy Jane Redfern, David M. Andrews, Paul Spencer Jones, Naimisha Trivedi, Angela Patikis, Michael C. Barnes, Mike D. Dowle

Publikováno v: Organic Letters. 5:4631-4634

[reaction: see text] In this, the second of two Letters, the optimization of the pyrrolidine-5,5-trans-lactam template (exemplified by 1a) as a mechanism-based inhibitor of hepatitis C NS3/4A protease is described. "Right Box" analysis of cassette do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38887863b133f85a34524a3302dbc5da
https://doi.org/10.1021/ol035827n

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Developments in hepatitis C during 1996 - 1997

Autor: Berwyn E. Clarke, Martin J Slater

Publikováno v: Expert Opinion on Therapeutic Patents. 7:979-987

The prevalence of hepatitis C viral (HCV) infection worldwide is estimated at 500 m people. HCV infection invariably leads to cirrhosis, hepatocellular carcinoma and liver failure. The only available treatment is α-interferon, giving a sustained res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4450a1cbf5d5b5cb18073e00243c282e
https://doi.org/10.1517/13543776.7.9.979

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An unusually facile [3,3]-sigmatropic rearrangement in a stereospecific synthesis of novel 2′,3′-dideoxynucleoside precursors

Autor: Alan T. Hewson, Peter L Armstrong, Martin J. Slater, Iain C Coull

Publikováno v: Tetrahedron Letters. 36:4311-4314

The glycal 5 is converted to intermediates which undergo, under mild conditions, thermal aza-Claisen rearrangements, leading to the amides 7 and 8 and the 2-pyrimidone 9 , all potential precursors to 2′,3′-dideoxynucleosides.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1aed26796bca6e69f08a5c0a9afbf0b5
https://doi.org/10.1016/0040-4039(95)00747-z

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The design and application of target-focused compound libraries

Autor: Richard D Hill, David W. Sheppard, C. John Harris, Pieter F. W. Stouten, Martin J Slater

Publikováno v: Combinatorial Chemistry & High Throughput Screening

Target-focused compound libraries are collections of compounds which are designed to interact with an individual protein target or, frequently, a family of related targets (such as kinases, voltage-gated ion channels, serine/cysteine proteases). They

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7f473494aa3648cbae7d9bd02f4785
https://pubmed.ncbi.nlm.nih.gov/21521154

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