Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Martin J Simard"'
Autor:
Pascale Michaud, Vivek Nilesh Shah, Pauline Adjibade, Francois Houle, Miguel Quévillon Huberdeau, Rachel Rioux, Camille Lavoie-Ouellet, Weifeng Gu, Rachid Mazroui, Martin J Simard
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009511 (2021)
Once loaded onto Argonaute proteins, microRNAs form a silencing complex called miRISC that targets mostly the 3'UTR of mRNAs to silence their translation. How microRNAs are transported to and from their target mRNA remains poorly characterized. While
Externí odkaz:
https://doaj.org/article/bf20e363f9974ccf8c1c83e35d468b7c
Autor:
Guillaume Jannot, Pascale Michaud, Miguel Quévillon Huberdeau, Louis Morel-Berryman, James A Brackbill, Sandra Piquet, Katherine McJunkin, Kotaro Nakanishi, Martin J Simard
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006484 (2016)
MicroRNAs and Argonaute form the microRNA induced silencing complex or miRISC that recruits GW182, causing mRNA degradation and/or translational repression. Despite the clear conservation and molecular significance, it is unknown if miRISC-GW182 inte
Externí odkaz:
https://doaj.org/article/2c218caaad5344c49c9657cd210f4b08
Autor:
Guillaume Jannot, Pascale Michaud, Miguel Quévillon Huberdeau, Louis Morel-Berryman, James A Brackbill, Sandra Piquet, Katherine McJunkin, Kotaro Nakanishi, Martin J Simard
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006534 (2016)
[This corrects the article DOI: 10.1371/journal.pgen.1006484.].
Externí odkaz:
https://doaj.org/article/f558e6522c3741bea09bccd2bf1c0da4
Publikováno v:
PLoS Genetics, Vol 10, Iss 4, p e1004286 (2014)
microRNAs function in diverse developmental and physiological processes by regulating target gene expression at the post-transcriptional level. ALG-1 is one of two Caenorhabditis elegans Argonautes (ALG-1 and ALG-2) that together are essential for mi
Externí odkaz:
https://doaj.org/article/b5a9b49db15e4bfbb582fb2b5d87776c
Autor:
Alejandro Vasquez-Rifo, Gabriel D Bossé, Evelyne L Rondeau, Guillaume Jannot, Alexandra Dallaire, Martin J Simard
Publikováno v:
PLoS Genetics, Vol 9, Iss 11, p e1003961 (2013)
Many core components of the microRNA pathway have been elucidated and knowledge of their mechanisms of action actively progresses. In contrast, factors with modulatory roles on the pathway are just starting to become known and understood. Using a gen
Externí odkaz:
https://doaj.org/article/d2d781eb8e2047f1879855dc8601dc8e
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33144 (2012)
MiRNAs can regulate gene expression through versatile mechanisms that result in increased or decreased expression of the targeted mRNA and it could effect the expression of thousands of protein in a particular cell. An increasing body of evidence sug
Externí odkaz:
https://doaj.org/article/843924bf49674c7f8e42cc0c71334745
Autor:
Alejandro Vasquez-Rifo, Guillaume Jannot, Javier Armisen, Michel Labouesse, Syed Irfan Ahmad Bukhari, Evelyne L Rondeau, Eric A Miska, Martin J Simard
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33750 (2012)
The genes alg-1 and alg-2 (referred to as "alg-1/2") encode the Argonaute proteins affiliated to the microRNA (miRNA) pathway in C. elegans. Bound to miRNAs they form the effector complex that effects post-transcriptional gene silencing. In order to
Externí odkaz:
https://doaj.org/article/33a5450f7e414a09876534539ef9d7c0
Autor:
Prasad K Padmanabhan, Carole Dumas, Mukesh Samant, Annie Rochette, Martin J Simard, Barbara Papadopoulou
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52612 (2012)
In contrast to nearly all eukaryotes, the Old World Leishmania species L. infantum and L. major lack the bona fide RNAi machinery genes. Interestingly, both Leishmania genomes code for an atypical Argonaute-like protein that possesses a PIWI domain b
Externí odkaz:
https://doaj.org/article/4525f672ed7449188a5d2587636f52e8
Publikováno v:
PLoS Biology, Vol 2, Iss 4, p E98 (2004)
Hundreds of microRNAs (miRNAs) and endogenous small interfering RNAs (siRNAs) have been identified from both plants and animals, yet little is known about their biochemical modes of action or biological functions. Here we report that 2'-O-methyl olig
Externí odkaz:
https://doaj.org/article/4539f2509eda48698e0b4ccd1ad70acf
Autor:
Anisha Pal, Vaishnav Vasudevan, François Houle, Michael Lantin, Katherine A. Maniates, Miguel Quévillon Huberdeau, Allison L. Abbott, Martin J. Simard
Publikováno v:
bioRxiv
microRNAs regulate gene expression through interaction with an Argonaute protein family member. While some members of this protein family retain an enzymatic activity capable of cleaving RNA molecules complementary to Argonaute-bound small RNAs, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efb46c33862f938c5deee9dbe0d6e31
https://doi.org/10.1101/2023.01.19.524781
https://doi.org/10.1101/2023.01.19.524781
