Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Martin J Shearer"'
Autor:
Paul Clarke, Martin J. Shearer, David J. Card, Amy Nichols, Vennila Ponnusamy, Ajit Mahaveer, Kieran Voong, Karen Dockery, Nicky Holland, Shaveta Mulla, Lindsay J. Hall, Cecile Maassen, Petra Lux, Leon J. Schurgers, Dominic J. Harrington
Publikováno v:
Journal of Thrombosis and Haemostasis, 20(12), 2773-2785. Wiley
BACKGROUND: There is near-global consensus that all newborns be given parenteral vitamin K1 (VK1 ) at birth as prophylaxis against VK deficiency bleeding (VKDB). Breastmilk has a low VK content and cases of late VKDB are reported in exclusively breas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88200e66d0a705bd9a10d92f8e588352
https://doi.org/10.1111/jth.15874
https://doi.org/10.1111/jth.15874
Autor:
Martin J. Shearer, Paul Newman
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 3, Pp 345-362 (2014)
In contrast to other fat-soluble vitamins, dietary vitamin K is rapidly lost to the body resulting in comparatively low tissue stores. Deficiency is kept at bay by the ubiquity of vitamin K in the diet, synthesis by gut microflora in some species, an
Externí odkaz:
https://doaj.org/article/9ad8adf7d79444f2a0cab424004ee4c4
Autor:
Dominic J. Harrington, Robin Soper, Christine Edwards, Geoffrey F. Savidge, Stephen J. Hodges, Martin J. Shearer
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 5, Pp 1053-1060 (2005)
We describe a method for the determination of the two major urinary metabolites of vitamin K as the methyl esters of their aglycone structures, 2-methyl-3-(3′-3′-carboxymethylpropyl)-1,4-naphthoquinone (5C-aglycone) and 2-methyl-3-(5′-carboxy-3
Externí odkaz:
https://doaj.org/article/9e1feba6324a4afa8ace8877a730de52
Autor:
Leon J. Schurgers, Martin J. Shearer, Berry A.M. Soute, Ibrahim Elmadfa, Julia Harvey, Karl-Heinz Wagner, Richard Tomasch, Cees Vermeer
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 6, Pp 878-884 (2002)
Little is known of how the fat components of diets influence the absorption and metabolism of vitamin K and the possible consequences to the synthesis of vitamin K-dependent (VKD) proteins in different target organs. We have evaluated the effects of
Externí odkaz:
https://doaj.org/article/c8eaf83c55604c23a07df4f99df748c0
Publikováno v:
Advances in Hematology, Vol 2014 (2014)
5-Methyltetrahydrofolate (5-MTHF) is the predominant form of folate and a strong determinant of homocysteine concentrations. There is evidence that suboptimal 5-MTHF availability is a risk factor for cardiovascular disease independent of homocysteine
Externí odkaz:
https://doaj.org/article/be95f2ccb98c4be3bee65e5450ff1dd8
Autor:
Martin J. Shearer
Publikováno v:
Archives of disease in childhood. 105(5)
Vitamin K deficiency bleeding (VKDB) is a rare haemostatic disorder that occurs in the first 6 months of life and is subclassified, according to age of presentation, as either early, classical or late VKDB. Late VKDB (day 8 onwards) is the most insid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91911bdefbd02241569b4bd0e4a74499
https://pubmed.ncbi.nlm.nih.gov/32060031
https://pubmed.ncbi.nlm.nih.gov/32060031
Autor:
Martin J. Shearer
Publikováno v:
Blood. 132:1867-1869
Warfarin, acenocoumarol, phenprocoumon, and fluindione are commonly prescribed oral anticoagulants for the prevention and treatment of thromboembolic disorders. These anticoagulants function by impairing the biosynthesis of active vitamin K–depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256b893d7b71d7994c5b9b2cc107a29a
https://doi.org/10.1182/blood-2018-08-869578
https://doi.org/10.1182/blood-2018-08-869578
Autor:
Jessie L Ellis, Xueyan Fu, Ala Al Rajabi, Elena N. Naumova, Edward Saltzman, Kathryn Barger, Sarah L. Booth, Martin J Shearer, Michael A. Grusak
BACKGROUND: Phylloquinone is the primary form of vitamin K in the diet and circulation. Large intra- and interindividual variances in circulating phylloquinone have been partially attributed to age. However, little is known about the nondietary facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a915de2d7bfa827625bab221fccd246b
https://europepmc.org/articles/PMC6351140/
https://europepmc.org/articles/PMC6351140/
Autor:
Elizabeth Sarah Cockayne, Kath Wright, Thomas Bradley, Joy Adamson, David J. Torgerson, Susan A Lanham-New, Martin J. Shearer, Andrew Mott
Publikováno v:
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 30(8)
Vitamin K may affect bone mineral density and fracture incidence. Since publication of a previous systematic review the integrity of some of the previous evidence has been questioned and further trials have been published. Therefore an update to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d3f59380d565ffc465a56aacfab85e
https://pubmed.ncbi.nlm.nih.gov/32965511
https://pubmed.ncbi.nlm.nih.gov/32965511
Autor:
Martin J. Shearer, Toshio Okano
Publikováno v:
Annual review of nutrition. 38
Vitamin K (VK) is an essential cofactor for the post-translational conversion of peptide-bound glutamate to γ-carboxyglutamate. The resultant vitamin K–dependent proteins are known or postulated to possess a variety of biological functions, chiefl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c686824f08f2716f3dde051256649a3
https://pubmed.ncbi.nlm.nih.gov/29856932
https://pubmed.ncbi.nlm.nih.gov/29856932