Výsledky vyhledávání - "Martin J Greaves"

Expression of Kinase-defective Mutants of c-Src in Human Metastatic Colon Cancer Cells Decreases Bcl-xL and Increases Oxaliplatin- and Fas-induced Apoptosis

Autor: Valerie G Brunton, Gareth J. Griffiths, Christopher Cawthorne, Natalie A Reeves, Michael J. Tilby, Margaret C. Frame, Martin J Greaves, Paul Workman, Caroline Dive, D. Graham Pearson, Chris J. Ottley, Mei Yee Koh

Publikováno v: Journal of Biological Chemistry. 279:46113-46121

Tumor resistance to current drugs prevents curative treatment of human colon cancer. A pressing need for effective, tumor-specific chemotherapies exists. The non-receptor-tyrosine kinase c-Src is overexpressed in70% of human colon cancers and represe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bcc029b9b1f0b30eabb2240792ddba
https://doi.org/10.1074/jbc.m408550200

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The relationship between radiation-induced G1 arrest and chromosome aberrations in Li-Fraumeni fibroblasts with or without germline TP53 mutations

Autor: Anne R Spreadborough, Jillian M. Birch, Martin J Greaves, Jennifer Varley, John M Boyle, David Scott

Publikováno v: British Journal of Cancer

We previously showed that cultured fibroblasts from patients with the cancer-prone Li-Fraumeni (LF) syndrome, having heterozygous germline TP53 mutations, sustain less ionizing radiation-induced permanent G1 arrest than normal fibroblasts. In contras

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7fa67cca2e2c373cf6da60bcd4484f
https://doi.org/10.1054/bjoc.2001.1896

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Characterization of germline TP53 splicing mutations and their genetic and functional analysis

Autor: Anna Kelsey, Mary R Thorncroft, John M Boyle, Jillian M. Birch, Martin J Greaves, Gail McGown, Jennifer Varley, Gavin R M White, Claire L Attwooll

Publikováno v: Oncogene. 20:2647-2654

Germline TP53 splicing mutations have been described infrequently (>2%) in the literature, however in a series of 40 patients and families identified by our group in which there are germline TP53 mutations, seven affect splicing (18%). The low figure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4dce3b1838b3282a98970b29cd37299
https://doi.org/10.1038/sj.onc.1204369

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Radiation-induced G1 arrest is not defective in fibroblasts from Li-Fraumeni families without TP53 mutations

Autor: Richard Camplejohn, Jennifer Varley, John M Boyle, Stephen A Roberts, Jillian M. Birch, Martin J Greaves

Publikováno v: British Journal of Cancer

Radiation-induced G1 arrest was studied in four classes of early passage skin fibroblasts comprising 12 normals, 12 heterozygous (mut/wt) TP53 mutation-carriers, two homozygous (mut/–) TP53 mutation-carriers and 16 strains from nine Li-Fraumeni syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87e316b9ca82a04a21b113fcf2a4ee2
https://doi.org/10.1038/sj.bjc.6690265

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A radiation hybrid panel for human Chromosome 6q

Autor: Mauro Santibanez-Koref, Margaret Fox, John M Boyle, Yvonne H. Edwards, Martin J. Greaves, Vassilis Orphanos

Publikováno v: Mammalian Genome. 6:285-290

A panel of 63 radiation-reduced hybrids has been derived from a mouse cell line containing a neo-marked human Chromosome (Chr) 6, primarily to provide a resource for higher resolution localization of new markers. Hybrids were generated with radiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc2c2c7bab3831afe18fd5c8c95a5ed
https://doi.org/10.1007/bf00352418

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Circulating biomarkers of cell death after treatment with the BH-3 mimetic ABT-737 in a preclinical model of small-cell lung cancer

Autor: Timothy H Ward, Caroline Dive, Alex R. Shoemaker, Steven W. Elmore, Martin J Greaves, Kelly Foster, Saul H. Rosenberg, Jeffrey Cummings, Kathryn Simpson, Dimitra Micha

Publikováno v: Clinical Cancer Research. American Association for Cancer Research Inc.
Micha, D, Cummings, J, Shoemaker, A, Elmore, S, Foster, K, Greaves, M, Ward, T, Rosenberg, S, Dive, C & Simpson, K 2008, ' Circulating biomarkers of cell death after treatment with the BH-3 mimetic ABT-737 in a preclinical model of small-cell lung cancer ', Clinical Cancer Research .

Purpose: This study evaluated epithelial cell death ELISAs that measure circulating cytokeratin 18 in mice bearing small-cell lung cancer xenografts treated with a proapoptotic dose of the BH-3 mimetic ABT-737. Experimental Design: H146 tumor–beari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be12c4ec353fde29dc24756497bf2507
https://research.vumc.nl/en/publications/836b3ac5-6d18-412a-b720-18063d5b7a0e

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Childhood acute lymphoblastic leukemia and infections in the first year of life: a report from the United Kingdom Childhood Cancer Study

Autor: J. Simpson, Eve Roman, Sally E. Kinsey, Chris Mitchell, Tim O B Eden, Jillian M. Birch, Martin J Greaves, Pat Ansell, Patricia A. McKinney

Publikováno v: American journal of epidemiology. 165(5)

The United Kingdom Childhood Cancer Study was designed to examine the relation between childhood cancer and preceding exposure to infectious diseases. The authors analyzed the relation between diagnosis (1991-1996) of acute lymphoblastic leukemia (AL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df7f567184c031a4bb2920d2630d943
https://pubmed.ncbi.nlm.nih.gov/17576747

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Delayed chromosome changes in gamma-irradiated normal and Li-Fraumeni fibroblasts

Autor: David Scott, Anne R Spreadborough, John M Boyle, Jillian M. Birch, Martin J Greaves, Jennifer Varley

Publikováno v: Radiation research. 157(2)

Knockout mice with only one Trp53 allele (+/- genotype) are highly susceptible to radiation-induced cancers, possibly through numerical chromosome changes. Patients with the Li-Fraumeni syndrome, having heterozygous TP53 germline mutations (+/mut gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3eabda846f69ec2b3c567ff86f4a59d
https://pubmed.ncbi.nlm.nih.gov/11835679

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Chromosome instability in fibroblasts derived from Li-Fraumeni syndrome families without TP53 mutations

Autor: John M Boyle, Jillian M. Birch, David Scott, Martin J. Greaves, Anne R Spreadborough

Publikováno v: British Journal of Cancer

The mean in vitro lifespan of dermal fibroblast strains derived from cancer-affected individuals belonging to families conforming to the classical Li-Fraumeni-syndrome or the Li-Fraumeni-like syndrome (LF strains), but in whom no TP53 mutation has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32fbf89a8e1ed9678818ff4799c461dc
https://pubmed.ncbi.nlm.nih.gov/11027425

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Genomic alterations associated with loss of heterozygosity for TP53 in Li-Fraumeni syndrome fibroblasts

Autor: Jillian M. Birch, Martin J Greaves, E C Burt, Jennifer Varley, John M Boyle, Louise A James

Publikováno v: British Journal of Cancer

Studies of Li-Fraumeni syndrome fibroblasts heterozygous for germline TP53 mutations have shown that loss of heterozygosity (LOH) occurs during passaging and is associated with genomic instability, such as chromosomal aberrations and aneuploidy. to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbab904e2061f2086dfd0a11a231bb0
https://pubmed.ncbi.nlm.nih.gov/10945493

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