Výsledky vyhledávání - "Martin J, Berg"

Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

Autor: Ju-Hyun Lee, Dun-Sheng Yang, Chris N. Goulbourne, Eunju Im, Philip Stavrides, Anna Pensalfini, Han Chan, Cedric Bouchet-Marquis, Cynthia Bleiwas, Martin J. Berg, Chunfeng Huo, James Peddy, Monika Pawlik, Efrat Levy, Mala Rao, Mathias Staufenbiel, Ralph A. Nixon

Publikováno v: Nature Neuroscience. 25:688-701

Autophagy is markedly impaired in Alzheimer’s disease (AD). Here we reveal unique autophagy dysregulation within neurons in five AD mouse models in vivo and identify its basis using a neuron-specific transgenic mRFP-eGFP-LC3 probe of autophagy and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5bc48852728fc53fbe780572287d2d
https://doi.org/10.1038/s41593-022-01084-8

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Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca

Autor: Pearl P Y, Lie, Lang, Yoo, Chris N, Goulbourne, Martin J, Berg, Philip, Stavrides, Chunfeng, Huo, Ju-Hyun, Lee, Ralph A, Nixon

Publikováno v: Science advances. 8(17)

Dysfunction and mistrafficking of organelles in autophagy- and endosomal-lysosomal pathways are implicated in neurodegenerative diseases. Here, we reveal selective vulnerability of maturing degradative organelles (late endosomes/amphisomes) to diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03782728671ebb0c1216b139ca8bab8c
https://pubmed.ncbi.nlm.nih.gov/35486730

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Neurofilament light interaction with GluN1 modulates neurotransmission and schizophrenia-associated behaviors

Autor: Martin J. Berg, Daniel C. Javitt, John F. Smiley, Cynthia Bleiwas, Mala V. Rao, Jean-Pierre Julien, Balapal S. Basavarajappa, Henry Sershen, Audrey Hashim, Sandipkumar Darji, Donald A. Wilson, Ralph A. Nixon, Shivakumar Subbanna, Veeranna, Aidong Yuan, David N. Guifoyle, Asok Kumar

Publikováno v: Translational Psychiatry, Vol 8, Iss 1, Pp 1-12 (2018)
Translational Psychiatry

Neurofilament (NFL) proteins have recently been found to play unique roles in synapses. NFL is known to interact with the GluN1 subunit of N-methyl-d-aspartic acid (NMDAR) and be reduced in schizophrenia though functional consequences are unknown. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2dd9e3d12210628dd62e571bfb5f4af
http://link.springer.com/article/10.1038/s41398-018-0194-7

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mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy

Autor: Matteo Bordi, Sandipkumar Darji, Ying Jiang, Ralph A. Nixon, Martin J. Berg, Marian Mellén, Asok Kumar, Yutaka Sato

Publikováno v: Cell Death & Disease
DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria
Universidad Francisco de Vitoria
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
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Cell Death and Disease, Vol 10, Iss 8, Pp 1-17 (2019)

Down syndrome (DS), a complex genetic disorder caused by chromosome 21 trisomy, is associated with mitochondrial dysfunction leading to the accumulation of damaged mitochondria. Here we report that mitophagy, a form of selective autophagy activated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80cff389e6292e4a399b48fb502af4e9
https://pubmed.ncbi.nlm.nih.gov/31332166

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Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99)

Autor: Ying Jiang, Asok Kumar, Ralph A. Nixon, Urmi Bandyopadhyay, Yutaka Sato, Ana Maria Cuervo, Panaiyur S. Mohan, Antonio Diaz, Matteo Bordi, Eunju Im, Martin J. Berg, Sandipkumar Darji

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(27)

Lysosomal failure underlies pathogenesis of numerous congenital neurodegenerative disorders and is an early and progressive feature of Alzheimer's disease (AD) pathogenesis. Here, we report that lysosomal dysfunction in Down ayndrome (trisomy 21), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ddfb678207c8b1738dc8b2d4df4e78c
https://pubmed.ncbi.nlm.nih.gov/31043483

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Endosomal Dysfunction Induced by Directly Over-Activating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease

Autor: Balapal S. Basavarajappa, Philip Stavrides, Chris N. Goulbourne, Monika Pawlik, Ju-Hyun Lee, Anna Pensalfini, Cynthia Bleiwas, Seonil Kim, Sandipkumar Darji, Martin J. Berg, Ying Jiang, John F. Smiley, Ralph A. Nixon, Shivakumar Subbanna, Chunfeng Huo

Publikováno v: SSRN Electronic Journal.

Neuronal endosomal dysfunction, the earliest known pathobiology specific to Alzheimer’s disease (AD), is mediated by aberrant activation of Rab5 triggered by APP-βeta secretase cleaved C-terminal fragment (APP-βCTF). To distinguish pathophysiolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d34bbc7bde783e5f926879b97b97951
https://doi.org/10.2139/ssrn.3512167

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Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

Autor: Ralph A. Nixon, Matteo Bordi, Shaoli Che, Panaiyur S. Mohan, Martin J. Berg, Corrinne M. Peterhoff, Stephen D. Ginsberg, Melissa J. Alldred

Publikováno v: Autophagy

Defective autophagy contributes to Alzheimer disease (AD) pathogenesis although evidence is conflicting on whether multiple stages are impaired. Here, for the first time, we have comprehensively evaluated the entire autophagic process specifically in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23cc7613684b84c34f72f4ee32819d24
http://europepmc.org/articles/PMC5173282

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Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer’s Disease

Autor: Monika Pawlik, Seonil Kim, Chunfeng Huo, Shivakumar Subbanna, Philip Stavrides, Ju-Hyun Lee, Chris N. Goulbourne, Balapal S. Basavarajappa, Sandipkumar Darji, Ying Jiang, Cynthia Bleiwas, John F. Smiley, Ralph A. Nixon, James Peddy, Anna Pensalfini, Martin J. Berg

Publikováno v: Cell Rep

Neuronal endosomal dysfunction, the earliest known pathobiology specific to Alzheimer’s disease (AD), is mediated by the aberrant activation of Rab5 triggered by APP-β secretase cleaved C-terminal fragment (APP-βCTF). To distinguish pathophysiolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b335d284c55ba66ea10590f9c7d19c
https://doi.org/10.1016/j.celrep.2020.108420

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Neurofilament Subunits are Integral Components of Synapses and Modulate Neurotransmission and Behavior In Vivo

Autor: V M-Y Lee, J Julien, Audrey Hashim, J.E. Lee, Ralph A. Nixon, Panaiyur S. Mohan, Martin J. Berg, Mala V. Rao, Aidong Yuan, Asok Kumar, Veeranna, Henry Sershen, Victor V. Dyakin, Yutaka Sato, Balapal S. Basavarajappa

Publikováno v: Molecular psychiatry

Synaptic roles for neurofilament proteins have rarely been considered. Here, we establish all four neurofilament subunits as integral resident proteins of synapses. Compared to the population in axons, neurofilament subunits isolated from synapses ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d44477062f39a00b974a857d1e03d16
http://europepmc.org/articles/PMC4514553

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BACE and γ-Secretase Characterization and Their Sorting as Therapeutic Targets to Reduce Amyloidogenesis

Autor: Martin J. Berg, Neville Marks

Publikováno v: Neurochemical Research. 35:181-210

Secretases are named for enzymes processing amyloid precursor protein (APP), a prototypic type-1 membrane protein. This led directly to discovery of novel Aspartyl proteases (β-secretases or BACE), a tetramer complex γ-secretase (γ-SC) containing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eafaedf88e85aecf61a8cce02d6b7078
https://doi.org/10.1007/s11064-009-0054-1

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