Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Martin Indarte"'
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115024- (2023)
The pleckstrin homology [PH] domain is a structural fold found in more than 250 proteins making it the 11th most common domain in the human proteome. 25% of family members have more than one PH domain and some PH domains are split by one, or several
Externí odkaz:
https://doaj.org/article/7afab2546f8f43c7ba4c671b79b61540
Autor:
Garth Powis, Lynn Kirkpatrick, Robert C. Liddington, Laurie A. Bankston, Ricardo G. Correa, Fabiana I.A.L. Layng, Lei Du-Cuny, Robert Lemos, Shuxing Zhang, Emmanuelle J. Meuillet, Zamal Ahmed, Michael Scott, Geoffrey Grandjean, Nathan T. Ihle, Marco Maruggi, Roisin Puentes, Martin Indarte
An inhibitor of the pleckstrin homology domain of CNK1 selectively blocks the growth of mutant KRAS cells and tumors Supplemental Information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4049decc5165ea5a5548638457e6315
https://doi.org/10.1158/0008-5472.22421073
https://doi.org/10.1158/0008-5472.22421073
Autor:
Garth Powis, Lynn Kirkpatrick, Robert C. Liddington, Laurie A. Bankston, Ricardo G. Correa, Fabiana I.A.L. Layng, Lei Du-Cuny, Robert Lemos, Shuxing Zhang, Emmanuelle J. Meuillet, Zamal Ahmed, Michael Scott, Geoffrey Grandjean, Nathan T. Ihle, Marco Maruggi, Roisin Puentes, Martin Indarte
Cnk1 (connector enhancer of kinase suppressor of Ras 1) is a pleckstrin homology (PH) domain–containing scaffold protein that increases the efficiency of Ras signaling pathways, imparting efficiency and specificity to the response of cell prolifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::570ccd2ee8215290557b6c0ec2d39371
https://doi.org/10.1158/0008-5472.c.6510828.v1
https://doi.org/10.1158/0008-5472.c.6510828.v1
Autor:
Francesca M. Marassi, Martin Indarte, Roisin Puentes, Hei-Cheul Jeung, Alexander E. Aleshin, Laurie A. Bankston, Garth Powis, Ignacio I. Wistuba, Fabiana I.A.L. Layng, Shuxing Zhang, Ricardo G. Correa, Robert C. Liddington, Zamal Ahmed, Emmanuelle J. Meuillet, Yong Yao, Daniela G. Duenas, Lynn Kirkpatrick
Publikováno v:
Exp Cell Res
Plekha7 (Pleckstrin homology [PH] domain containing, family A member 7) regulates the assembly of proteins of the cytoplasmic apical zonula adherens junction (AJ), thus ensuring cell-cell adhesion and tight-junction barrier integrity. Little is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e929eb1613fa0052fdd02673a433457c
https://europepmc.org/articles/PMC8925131/
https://europepmc.org/articles/PMC8925131/
Autor:
Ricardo G. Correa, Nathan T. Ihle, Laurie A. Bankston, Robert Lemos, Lynn Kirkpatrick, Michael J. Scott, Shuxing Zhang, Robert C. Liddington, Martin Indarte, Fabiana I.A.L. Layng, Garth Powis, Geoffrey Grandjean, Zamal Ahmed, Lei Du-Cuny, Emmanuelle J. Meuillet, Roisin Puentes, Marco Maruggi
Publikováno v:
Cancer Res
Cnk1 (connector enhancer of kinase suppressor of Ras 1) is a pleckstrin homology (PH) domain-containing scaffold protein that increases the efficiency of Ras signaling pathways, imparting efficiency and specificity to the response of cell proliferati
Autor:
Ricardo G. Correa, Roisin Puentes, Nathan T. Ihle, Fabiana I.A.L. Layng, Robert Lemos, Mike Scott, Marco Maruggi, Lei Du-Cuny, Garth Powis, Laurie A. Bankston, Robert C. Liddington, Zamal Ahmed, Martin Indarte, Lynn Kirkpatrick, Emmanuelle J. Meuillet, Geoffrey Grandjean, Shuxing Zang
Publikováno v:
Cancer research. 79(12)
Cnk1 (connector enhancer of kinase suppressor of Ras 1) is a pleckstrin homology (PH) domain–containing scaffold protein that increases the efficiency of Ras signaling pathways, imparting efficiency and specificity to the response of cell prolifera
Autor:
Geoff Grandjean, Garth Powis, Roisin Delaney, Lynn Kirkpatrick, Robert Lemos, Martin Indarte, Marco Maruggi
Publikováno v:
Cancer Research. 77:3015-3015
Activating mutations of KRas is the most common proto-oncogenic event in human cancer but there remains no effective therapy for patients harboring mutated KRas (mut-KRas). Despite intense efforts, tight nucleotide binding, few defined pockets, and r
Autor:
Martin Indarte, Roisin Delaney, Geoff Grandjean, Garth Powis, Assael A. Madrigal, Mike Scott, D. Lynn Kirkpatrick
Publikováno v:
Molecular Cancer Therapeutics. 14:C131-C131
Introduction: KRAS, the predominant form of mutated RAS (mut-KRAS), is found in ∼25% of patient tumors across many cancer types and plays a critical role in driving tumor growth and resistance to therapy. We identified CNKSR1 (connector enhancer of
Autor:
Assael A. Madrigal, Martin Indarte, Mike Scott, Garth Powis, D. Lynn Kirkpatrick, Geoffrey Grandjean
Publikováno v:
Cancer Research. 75:2583-2583
Introduction: KRAS, the predominant form of mutated RAS (mut-KRAS), is found in ∼25% of patient tumors across many cancer types and plays a critical role in driving tumor growth and resistance to therapy. CNKSR1 (connector enhancer of kinase suppre
Publikováno v:
European Journal of Cancer. 50:160