Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Martin Hussey"'
Autor:
Mike Petrassi, Rob Barber, Celine Be, Sarah Beach, Brian Cox, Anne-Marie D’Souza, Nick Duggan, Martin Hussey, Roy Fox, Peter Hunt, Gabor Jarai, Takatoshi Kosaka, Paul Oakley, Viral Patel, Neil Press, David Rowlands, Clemens Scheufler, Oliver Schmidt, Honnappa Srinivas, Mary Turner, Rob Turner, John Westwick, Alison Wolfreys, Nuzhat Pathan, Simon Watson, Matthew Thomas
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Pulmonary arterial hypertension (PAH) has demonstrated multi-serotonin receptor dependent pathologies, characterized by increased tone (5-HT1B receptor) and complex lesions (SERT, 5-HT1B, 5-HT2B receptors) of the pulmonary vasculature together with r
Externí odkaz:
https://doaj.org/article/be575ec27b9d4ba3b8e400bbf8ceb145
Autor:
Andrew C. Pearce, Sylvie Chamoin, Matthew Thomas, Loren Jon, Deborah Haggart, Sonia P. Roberts, Christopher Thomson, John Reilly, Vikki Furminger, Ian N. Bruce, Peter Drückes, Sarah Cross, Rowan Stringer, Ferheen Baig, Satish Dayal, Duncan Shaw, Irena Konstantinova, Alex Michael Saunders, Stephen Paul Collingwood, Ben Wen, Valentina Molteni, Christine Tomlins, Martin Hussey, Lilya Sviridenko, Pascal Furet, Vince Yeh
Publikováno v:
Journal of Medicinal Chemistry. 59:7901-7914
A series of potent PDGFR inhibitors has been identified. The series was optimized for duration of action in the lung. A novel kinase occupancy assay was used to directly measure target occupancy after i.t. dosing. Compound 25 shows 24 h occupancy of
Autor:
David J. Rowlands, Lynn Loughlin, Martin Hussey, Sonia Roberts, Audrey F. Wright, Matthew Thomas, Kirsty M. Mair, Nicholas Duggan, Margaret Nilsen, Josephine Fullerton, Margaret R. MacLean
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 190:456-467
Rationale: The incidence of pulmonary arterial hypertension is greater in women, suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males, exogenously administered estrogen can protect against pulmonary hypertension
Autor:
Martin Hussey, Nuzhat Pathan, Oliver Schmidt, Gabor Jarai, Clemens Scheufler, Rob Barber, John Westwick, Anne-Marie D’Souza, Takatoshi Kosaka, Nick Duggan, Honnappa Srinivas, Alison Wolfreys, Peter Hunt, David J. Rowlands, Brian Cox, Paul Oakley, Mike Petrassi, Celine Be, Mary S. Turner, Matthew Thomas, Simon J. Watson, Rob Turner, Roy Fox, Neil John Press, Viral Patel, Sarah Beach
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 8 (2017)
Frontiers in Pharmacology, Vol 8 (2017)
Pulmonary arterial hypertension (PAH) has demonstrated multi-serotonin receptor dependent pathologies, characterized by increased tone (5-HT1B receptor) and complex lesions (SERT, 5-HT1B, 5-HT2B receptors) of the pulmonary vasculature together with r
Autor:
Caroline Foster, Paul G. Rainsbury, Alexandra Lenko, Alison Tappin, Martin Hussey, Jessica Sharp
Publikováno v:
The Pediatric infectious disease journal. 36(5)
Cushing's syndrome after topical ocular corticosteroid use is extremely rare. We describe a case of symptomatic Cushing's syndrome in an adolescent male with sight-threatening vernal keratoconjunctivitis on antiretroviral therapy for HIV-1 infection
Autor:
Loredana Ciuclan, Nicholas W. Morrell, Nicholas Duggan, Liqun Dong, Daniel Sutton, Jenny Simmons, Gino Van Heeke, Gerald Dubois, Karen England, Matthew Thomas, Martin Hussey, Kelly-Ann Sheppard, Gabor Jarai, Matthew J. Edwards
Publikováno v:
The American Journal of Pathology. 183:1461-1473
The expression of the bone morphogenetic protein antagonist, Gremlin 1, was recently shown to be increased in the lungs of pulmonary arterial hypertension patients, and in response to hypoxia. Gremlin 1 released from the vascular endothelium may inhi
Autor:
Catherine Ledent, Martin Hussey, Susanna M.O. Hourani, Ian Kitchen, David Ribé, David Sawbridge, Sapna Thakur, Jian-Mei Li
Publikováno v:
Free Radical Biology and Medicine. 44:1433-1442
Cardiac tissues express constitutively an NADPH oxidase, which generates reactive oxygen species (ROS) and is involved in redox signaling. Myocardial metabolism generates abundant adenosine, which binds to its receptors and plays important roles in c
Publikováno v:
Pain. 129:287-294
Adenosine is a neuromodulator with complex effects on pain pathways. Mice lacking the adenosine A2A receptor are hypoalgesic, and have altered analgesic responses to receptor-selective opioid agonists. These and other findings suggest a role for the
Publikováno v:
Pharmacologytherapeutics. 138(3)
As we uncover the complex pathophysiology underlying idiopathic and familial pulmonary arterial hypertension, multiple disease associated pathways, cell types and processes reveal links to elements of the serotonin system. Beyond the original 'seroto
Autor:
David J. Rowlands, Sarah Beach, Martin Hussey, Victoria J. Burton, Margaret R. MacLean, Peter Jones, Olivier Bonneau, Roy Fox, Irena Konstantinova, Nicholas Duggan, Robert B. Good, Andrew C. Pearce, Loredana Ciuclan, John Westwick, Matthew Thomas, Gabor Jarai, Ieuan Clay
Publikováno v:
American journal of respiratory and critical care medicine. 187(1)
Whether idiopathic, familial, or secondary to another disease, pulmonary arterial hypertension (PAH) is characterized by increased vascular tone, neointimal hyperplasia, medial hypertrophy, and adventitial fibrosis. Imatinib, a potent receptor tyrosi