Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Martin Horak"'
Autor:
Marketa Chvojkova, David Kolar, Katarina Kovacova, Lada Cejkova, Anna Misiachna, Kristina Hakenova, Lukas Gorecki, Martin Horak, Jan Korabecny, Ondrej Soukup, Karel Vales
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116821- (2024)
Therapeutic options for Alzheimer’s disease are limited. Dual compounds targeting two pathways concurrently may enable enhanced effect. The study focuses on tacrine derivatives inhibiting acetylcholinesterase (AChE) and simultaneously N-methyl-D-as
Externí odkaz:
https://doaj.org/article/ba09458e987a4172bb5b911d5bb2a16e
Autor:
Nataliya Romanyuk, Kristyna Sintakova, Ivan Arzhanov, Martin Horak, Chirag Gandhi, Meena Jhanwar-Uniyal, Pavla Jendelova
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
IntroductionNeural stem cells (NSCs) are essential for both embryonic development and adult neurogenesis, and their dysregulation causes a number of neurodevelopmental disorders, such as epilepsy and autism spectrum disorders. NSC proliferation and d
Externí odkaz:
https://doaj.org/article/7ab80a36c6ed48ebbd6d19307952ee87
Autor:
Eva Mezeiova, Lukas Prchal, Martina Hrabinova, Lubica Muckova, Lenka Pulkrabkova, Ondrej Soukup, Anna Misiachna, Jiri Janousek, Jakub Fibigar, Tomas Kucera, Martin Horak, Galina F. Makhaeva, Jan Korabecny
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 173, Iss , Pp 116399- (2024)
The search for novel drugs to address the medical needs of Alzheimer's disease (AD) is an ongoing process relying on the discovery of disease-modifying agents. Given the complexity of the disease, such an aim can be pursued by developing so-called mu
Externí odkaz:
https://doaj.org/article/567776fbc85843eba2bb66f04d9469c0
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S426-S427 (2023)
Externí odkaz:
https://doaj.org/article/f32fd60a04004897ba8b70b1e52c5744
Autor:
Barbora Svobodova, Lenka Pulkrabkova, Dawid Panek, Anna Misiachna, Marharyta Kolcheva, Rudolf Andrys, Jiri Handl, Jan Capek, Pavlina Nyvltova, Tomas Rousar, Lukas Prchal, Vendula Hepnarova, Martina Hrabinova, Lubica Muckova, Daniela Tosnerova, Galina Karabanovich, Vladimir Finger, Ondrej Soukup, Martin Horak, Jan Korabecny
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9124 (2023)
Alzheimer’s disease (AD) is a complex disease with an unknown etiology. Available treatments, limited to cholinesterase inhibitors and N-methyl-d-aspartate receptor (NMDAR) antagonists, provide symptomatic relief only. As single-target therapies ha
Externí odkaz:
https://doaj.org/article/5997ebc1604b46dfa3bcaf7b7054b542
Publikováno v:
Journal of Competitiveness, Vol 12, Iss 1, Pp 57-73 (2020)
Cluster managers have less authority compared to managers in companies, with the work of cluster managers based rather on negotiation than on issuing instructions. Nevertheless, dynamic changes regarding environment and customer needs in general have
Externí odkaz:
https://doaj.org/article/140870f7ae714abfbc8da335927c4c57
Autor:
Kristyna Skrenkova, Katarina Hemelikova, Marharyta Kolcheva, Stepan Kortus, Martina Kaniakova, Barbora Krausova, Martin Horak
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Abstract N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors that play an essential role in mediating excitatory neurotransmission in the mammalian central nervous system (CNS). Functional NMDARs are tetramers composed of GluN1
Externí odkaz:
https://doaj.org/article/f472834e09084930aa0fbf6223cd8223
Autor:
Martin Horak, Petra Barackova, Emily Langore, Jakub Netolicky, Paula Rivas-Ramirez, Kristyna Rehakova
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
N-methyl-D-aspartate receptors (NMDARs) belong to a family of ionotropic glutamate receptors that play essential roles in excitatory neurotransmission and synaptic plasticity in the mammalian central nervous system (CNS). Functional NMDARs consist of
Externí odkaz:
https://doaj.org/article/d8e58f08922946658387951b29b1c6b5
Autor:
Jan Konecny, Anna Misiachna, Martina Hrabinova, Lenka Pulkrabkova, Marketa Benkova, Lukas Prchal, Tomas Kucera, Tereza Kobrlova, Vladimir Finger, Marharyta Kolcheva, Stepan Kortus, Daniel Jun, Marian Valko, Martin Horak, Ondrej Soukup, Jan Korabecny
Publikováno v:
Biomolecules, Vol 11, Iss 1, p 3 (2020)
Alzheimer’s disease (AD) is a complex disorder with unknown etiology. Currently, only symptomatic therapy of AD is available, comprising cholinesterase inhibitors and N-methyl-d-aspartate (NMDA) receptor antagonists. Drugs targeting only one pathol
Externí odkaz:
https://doaj.org/article/d6ee28dbc6f147f48bce851d85867db0
Autor:
Kristyna Skrenkova, Sanghyeon Lee, Katarina Lichnerova, Martina Kaniakova, Hana Hansikova, Martin Zapotocky, Young Ho Suh, Martin Horak
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
N-methyl-D-aspartate receptors (NMDARs) play critical roles in both excitatory neurotransmission and synaptic plasticity. NMDARs containing the nonconventional GluN3A subunit have different functional properties compared to receptors comprised of Glu
Externí odkaz:
https://doaj.org/article/f06ed3023adf447b9d729b86bc265605