Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Martin Holcik"'
Autor:
Nahya Awada, Martin Holcik
Publikováno v:
JIMD Reports, Vol 65, Iss 2, Pp 63-84 (2024)
Abstract Canadian patients and families affected by rare genetic lysosomal storage diseases (LSDs) suffer from numerous challenges related to disease management, including issues navigating healthcare and social support services, access to orphan dru
Externí odkaz:
https://doaj.org/article/23f5d62e598342ccbe0d29c2d484678d
Autor:
Krishna Bhattarai, Martin Holcik
Publikováno v:
Frontiers in Virology, Vol 2 (2022)
Understanding the host-virus interactions helps to decipher the viral replication strategies and pathogenesis. Viruses have limited genetic content and rely significantly on their host cell to establish a successful infection. Viruses depend on the h
Externí odkaz:
https://doaj.org/article/4f481c4f8f334a3991d8b983ede19e06
Autor:
Thet Fatica, Turaya Naas, Urszula Liwak, Hannah Slaa, Maryam Souaid, Brianna Frangione, Ribal Kattini, Antoine Gaudreau-Lapierre, Laura Trinkle-Mulcahy, Pranesh Chakraborty, Martin Holcik
Publikováno v:
Genes, Vol 14, Iss 5, p 1043 (2023)
Mitochondrial diseases are a group of heterogeneous disorders caused by dysfunctional mitochondria. Interestingly, a large proportion of mitochondrial diseases are caused by defects in genes associated with tRNA metabolism. We recently discovered tha
Externí odkaz:
https://doaj.org/article/fab283e1c6674bfcb1cabe2d023cea3a
Autor:
Maryam Hajikarimlou, Mohsen Hooshyar, Noor Sunba, Nazila Nazemof, Mohamed Taha Moutaoufik, Sadhena Phanse, Kamaledin B. Said, Mohan Babu, Martin Holcik, Bahram Samanfar, Myron Smith, Ashkan Golshani
Publikováno v:
Journal of Fungi, Vol 9, Iss 4, p 445 (2023)
Mitochondria possess their own DNA (mtDNA) and are capable of carrying out their transcription and translation. Although protein synthesis can take place in mitochondria, the majority of the proteins in mitochondria have nuclear origin. 3′ and 5′
Externí odkaz:
https://doaj.org/article/7d898a43240d4b4ab3e94a9c8bf7c4cf
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0276883 (2022)
BackgroundMitochondrial diseases are a large group of genetically heterogeneous and clinically diverse disorders. Diagnosis often takes many years for which treatment may not exist. Registries are often used to conduct research, establish natural dis
Externí odkaz:
https://doaj.org/article/113e4c82865e4e90828bae7cc034707f
Autor:
Christine Péladeau, Nadine Adam, Lucas M. Bronicki, Adèle Coriati, Mohamed Thabet, Hasanen Al-Rewashdy, Jason Vanstone, Alan Mears, Jean-Marc Renaud, Martin Holcik, Bernard J. Jasmin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
One potential approach for the treatment of Duchenne muscular dysrophy is to increase expression of the dystrophin homolog utrophin. Here, the authors show that eEF1A2 regulates utrophin expression, and show that 2 FDA-approved drugs upregulate eEIF1
Externí odkaz:
https://doaj.org/article/6bc7a05ce66e4135bb35be45df6c5df1
Autor:
Maryam Hajikarimlou, Houman Moteshareie, Katayoun Omidi, Mohsen Hooshyar, Sarah Shaikho, Tom Kazmirchuk, Daniel Burnside, Sarah Takallou, Narges Zare, Sasi Kumar Jagadeesan, Nathalie Puchacz, Mohan Babu, Myron Smith, Martin Holcik, Bahram Samanfar, Ashkan Golshani
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235033 (2020)
Lithium Chloride (LiCl) toxicity, mode of action and cellular responses have been the subject of active investigations over the past decades. In yeast, LiCl treatment is reported to reduce the activity and alters the expression of PGM2, a gene that e
Externí odkaz:
https://doaj.org/article/53e008f2d41e42c6b8717a121939d6e9
Autor:
Maryam Hajikarimlou, Kathryn Hunt, Grace Kirby, Sarah Takallou, Sasi Kumar Jagadeesan, Katayoun Omidi, Mohsen Hooshyar, Daniel Burnside, Houman Moteshareie, Mohan Babu, Myron Smith, Martin Holcik, Bahram Samanfar, Ashkan Golshani
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5730 (2020)
For decades, lithium chloride (LiCl) has been used as a treatment option for those living with bipolar disorder (BD). As a result, many studies have been conducted to examine its mode of action, toxicity, and downstream cellular responses. We know th
Externí odkaz:
https://doaj.org/article/8913c5a9fc644591ac4d1fe4f4a2d70f
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 3780 (2020)
tRNA nucleotidyl transferase 1 (TRNT1) is an essential enzyme catalyzing the addition of terminal cytosine-cytosine-adenosine (CCA) trinucleotides to all mature tRNAs, which is necessary for aminoacylation. It was recently discovered that partial los
Externí odkaz:
https://doaj.org/article/8dad628415a74693b133d14be6ac30c0
Autor:
Houman Moteshareie, Maryam Hajikarimlou, Alex Mulet Indrayanti, Daniel Burnside, Ana Paula Dias, Clara Lettl, Duale Ahmed, Katayoun Omidi, Tom Kazmirchuk, Nathalie Puchacz, Narges Zare, Sarah Takallou, Thet Naing, Raúl Bonne Hernández, William G Willmore, Mohan Babu, Bruce McKay, Bahram Samanfar, Martin Holcik, Ashkan Golshani
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0198704 (2018)
Heavy metal and metalloid contaminations are among the most concerning types of pollutant in the environment. Consequently, it is important to investigate the molecular mechanisms of cellular responses and detoxification pathways for these compounds
Externí odkaz:
https://doaj.org/article/3a5ff0093d334ed58ab379f31d1505ca