Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Martin Hoehne"'
Autor:
Markus M. Rinschen, Oleg Palygin, Ashraf El-Meanawy, Xavier Domingo-Almenara, Amelia Palermo, Lashodya V. Dissanayake, Daria Golosova, Michael A. Schafroth, Carlos Guijas, Fatih Demir, Johannes Jaegers, Megan L. Gliozzi, Jingchuan Xue, Martin Hoehne, Thomas Benzing, Bernard P. Kok, Enrique Saez, Markus Bleich, Nina Himmerkus, Ora A. Weisz, Benjamin F. Cravatt, Marcus Krüger, H. Paul Benton, Gary Siuzdak, Alexander Staruschenko
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Kidney metabolism in disease is important but not well understood. Here, using isotope-guided metabolomics, the authors show that lysine’s metabolic activity conveys kidney protection in hypertension through accelerated metabolism and physiological
Externí odkaz:
https://doaj.org/article/2e9849a398d242b7a32232ec6d46f7d8
Autor:
Thomas Benzing, Martin Hoehne, Hans Blom, Amer Ramdedovic, Linus Butt, Bernhard Schermer, David Unnersjoe-Jess, Peter F. Hoyer, Felix C Koehler, Roman-Ulrich Mueller
Publikováno v:
Kidney360
BACKGROUND: Diseases of the glomeruli, the renal filtration units, are a leading cause of progressive kidney disease. Assessment of the ultrastructure of podocytes at the glomerular filtration barrier is essential for diagnosing diverse disease entit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21b0c4e2b0d38fc7c73029e5fee2baa
https://pubmed.ncbi.nlm.nih.gov/35582181
https://pubmed.ncbi.nlm.nih.gov/35582181
Autor:
Markus M. Rinschen, Oleg Palygin, Ashraf El-Meanawy, Xavier Domingo-Almenara, Amelia Palermo, Lashodya V. Dissanayake, Daria Golosova, Michael A. Schafroth, Carlos Guijas, Fatih Demir, Johannes Jaegers, Megan L. Gliozzi, Jingchuan Xue, Martin Hoehne, Thomas Benzing, Bernard P. Kok, Enrique Saez, Markus Bleich, Nina Himmerkus, Ora A. Weisz, Benjamin F. Cravatt, Marcus Krüger, H. Paul Benton, Gary Siuzdak, Alexander Staruschenko
Publikováno v:
Rinschen, M M, Palygin, O, El-Meanawy, A, Domingo-Almenara, X, Palermo, A, Dissanayake, L V, Golosova, D, Schafroth, M A, Guijas, C, Demir, F, Jaegers, J, Gliozzi, M L, Xue, J, Hoehne, M, Benzing, T, Kok, B P, Saez, E, Bleich, M, Himmerkus, N, Weisz, O A, Cravatt, B F, Krüger, M, Benton, H P, Siuzdak, G & Staruschenko, A 2022, ' Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension ', Nature Communications, vol. 13, no. 1, 4099 . https://doi.org/10.1038/s41467-022-31670-0
Hypertension and kidney disease have been repeatedly associated with genomic variants and alterations of lysine metabolism. Here, we combined stable isotope labeling with untargeted metabolomics to investigate lysine’s metabolic fate in vivo. Dieta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4038910596e82962c99ef5d32e19d1
https://pubmed.ncbi.nlm.nih.gov/35835746
https://pubmed.ncbi.nlm.nih.gov/35835746
Autor:
Martin Hoehne, Annika Wernerson, Lena Scott, Hans Blom, Bernhard Schermer, Peter F. Hoyer, Jaakko Patrakka, Anna Witasp, Linus Butt, Thomas Benzing, Lucas Kuehne, Paul T. Brinkkoetter, Hjalmar Brismar, David Unnersjoe-Jess
Many light-microscopy protocols have in recent years been published for visualization of ultrastructure in the kidney. These protocols present researchers with new tools to evaluate both foot process anatomy and effacement, as well as protein distrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acfde8f96cb27f08d0472553ad471ea9
https://doi.org/10.1101/2020.07.10.196733
https://doi.org/10.1101/2020.07.10.196733
Autor:
Alexander Kuczkowski, Matthias Kretzler, Paul T. Brinkkoetter, Sean Eddy, Jörg Höhfeld, Martin Hoehne, Lucas Kuehne, Markus M. Rinschen, Bernhard Schermer, Thomas Benzing, Sybille Koehler, Florian Grahammer, Bodo B. Beck, Christian Jüngst
Publikováno v:
J Am Soc Nephrol
Background Understanding podocyte-specific responses to injury at a systems level is difficult because injury leads to podocyte loss or an increase of extracellular matrix, altering glomerular cellular composition. Finding a window into early podocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66bc19c1f36cd422864f4a4e4f460ab
https://pubmed.ncbi.nlm.nih.gov/32047005
https://pubmed.ncbi.nlm.nih.gov/32047005
Autor:
Bernhard Schermer, Roman-Ulrich Müller, Martin Hoehne, Anastasiya Boltengagen, Mahdieh Rahmatollahi, Martin Kann, Thomas Benzing, Nikolaus Rajewsky, Nikos Karaiskos, Christine Kocks, Markus M. Rinschen, Haiyue Liu
Publikováno v:
Karaiskos, N, Rahmatollahi, M, Boltengagen, A, Liu, H, Hoehne, M, Rinschen, M, Schermer, B, Benzing, T, Rajewsky, N, Kocks, C, Kann, M & Müller, R U 2018, ' A single-cell transcriptome atlas of the mouse glomerulus ', Journal of the American Society of Nephrology, vol. 29, no. 8, pp. 2060-2068 . https://doi.org/10.1681/ASN.2018030238
Background Three different cell types constitute the glomerular filter: mesangial cells, endothelial cells, and podocytes. However, to what extent cellular heterogeneity exists within healthy glomerular cell populations remains unknown. Methods We us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee321374ff52c145e729c9c6743fd77
https://pure.au.dk/portal/da/publications/a-singlecell-transcriptome-atlas-of-the-mouse-glomerulus(9dd6c0b1-53d4-4e8a-900c-6ce5b8a71516).html
https://pure.au.dk/portal/da/publications/a-singlecell-transcriptome-atlas-of-the-mouse-glomerulus(9dd6c0b1-53d4-4e8a-900c-6ce5b8a71516).html
Autor:
Barbara A. Pulido Guevara, Hella S. Brönneke, Claudia Dafinger, Jan-Robin Wagener, Thomas Benzing, Andras Bilkei-Gorzo, Andreas Zimmer, Martin Hoehne, Sabine Bertsch, Bernhard Schermer, Linus A. Völker, Barbara A. Maar, Heiko Schweizer
Publikováno v:
Genes, brain, and behavior. 17(8)
Adhesion molecules of the immunoglobulin superfamily (IgSF) are essential for neuronal synapse development across evolution and control various aspects of synapse formation and maturation. Neph2, also known as Kirrel3, is an IgSF adhesion molecule im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f59f6224ad92ff93b676bac3b4bf11
https://pubmed.ncbi.nlm.nih.gov/30133126
https://pubmed.ncbi.nlm.nih.gov/30133126
Autor:
Linda Blomberg, Martin Hoehne, Bernhard Schermer, Markus M. Rinschen, Thomas Benzing, Christine Kurschat, Fabian Braun, Laura E. Frech, Gisela G. Slaats
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Fabry disease is a lysosomal storage disorder resulting from impaired alpha-galactosidase A (α-Gal A) enzyme activity due to mutations in the GLA gene. Currently, powerful diagnostic tools and in vivo research models to study Fabry disease are missi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7196be3dcf263e390f58382c7c1422f
https://pubmed.ncbi.nlm.nih.gov/30038331
https://pubmed.ncbi.nlm.nih.gov/30038331
Autor:
Roman-Ulrich Müller, Martin Hoehne, Agnes B. Fogo, Sandra Habbig, Heike Göbel, Rainer W.J. Kaiser, Bernhard Schermer, Katrin Bohl, Katja Höpker, Malte P. Bartram, Manaswita Jain, Gisela G. Slaats, Thomas Benzing
Publikováno v:
Kidney international. 95(4)
Recent human genetic studies have suggested an intriguing link between ciliary signaling defects and altered DNA damage responses in nephronophthisis (NPH) and related ciliopathies. However, the molecular mechanism and the role of altered DNA damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60f78b1d969d6ff879b8d93b681e98c
https://pubmed.ncbi.nlm.nih.gov/30770218
https://pubmed.ncbi.nlm.nih.gov/30770218
Autor:
Martin Hoehne, Florian Grahammer, Tobias B. Huber, Linus Butt, Rafael Kramann, Tamina Seeger-Nukpezah, Matthias Hackl, Christian K. Frese, Giuliano Ciarimboli, Max C. Liebau, Mahdieh Rahmatollahi, Thomas Benzing, Bodo B. Beck, Thomas Reinheckel, Claudia Dafinger, Bernhard Schermer, Markus M. Rinschen, Jochen Reiser, Simon Schneider, Julia Binz, Andreas Beyer, Martin Kann, Mehmet M. Altintas, Heike Goebel
In diseases of many parenchymatous organs, heterogenous detoriation of individual functional units determines the clinical prognosis. However, the molecular characterization of these subunits remains a technological challenge that needs to be address
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9970558e6bc52cb749f1082bcace45e3
https://doi.org/10.1101/194795
https://doi.org/10.1101/194795