Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t

Autor: Jie Zhao, Tin Min Htut, Xinshou Ouyang, Hongxing Li, Adedayo Hanidu, Rosemarie Sellati, Jay C. Unkeless, Jun Li, Shu Zhang, Jianfei Yang, Huabao Xiong, Xiang Li, Adrian T. Ting, Mark E. Labadia, Martin Hodge, Huiping Jiang, Min Yang, Lloyd Mayer

Publikováno v: European journal of immunology. 38(5)

Epstein-Barr virus-induced gene 3 (EBI3) associates with p28 to form IL-27 and with IL-12p35 to form IL-35. IL-27Ralpha(-/-) mice studies indicate that IL-27 negatively regulates Th17 cell differentiation. However, no EBI3, p28 or p35-deficiency stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c0ec73ad848d587d56cc2433ec77f5
https://pubmed.ncbi.nlm.nih.gov/18412165

Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming

Autor: Cooles, Faye, Tarn, Jessica, Lendrem, Dennis, Naamane, Najib, Lin, Chung Ma, Millar, Ben, Maney, Nicola, Anderson, Amy, Thalayasingam, Nishanthi, Diboll, Julie, Bondet, Vincent, Duffy, Darragh, Barnes, Michael, Smith, Graham, Ng, Sandra, Watson, David, Henkin, Rafael, Cope, Andrew, Reynard, Louise, Pratt, Arthur, Isaacs, John

Publikováno v: Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, In press, ⟨10.1136/annrheumdis-2022-222370⟩
Cooles, F A H, Tarn, J, Lendrem, D W, Naamane, N, Lin, C M A, Millar, B, Maney, N J, Anderson, A E, Thalayasingam, N, Diboll, J, Bondet, V, Duffy, D, Barnes, M R, Smith, G R, Ng, S, Watson, D, Henkin, R, Cope, A P, Reynard, L N, Pratt, A G & Isaacs, J D 2022, ' Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming ', Annals of the rheumatic diseases, vol. 81, no. 9, heartjnl-2022-222370, pp. 1214-1223 . https://doi.org/10.1136/annrheumdis-2022-222370
Ann Rheum Dis

ObjectivesAn interferon (IFN) gene signature (IGS) is present in approximately 50% of early, treatment naive rheumatoid arthritis (eRA) patients where it has been shown to negatively impact initial response to treatment. We wished to validate this ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ecfeba33e2085ceadcfd3a0dc4f6ae0
https://hal.science/hal-03699421/file/annrheumdis-2022-222370.full.pdf