Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Martin Hilgarth"'
Autor:
Rainer Hubmann, Susanne Schnabl, Mohammad Araghi, Christian Schmidl, André F. Rendeiro, Martin Hilgarth, Dita Demirtas, Farghaly Ali, Philipp B. Staber, Peter Valent, Christoph Zielinski, Ulrich Jäger, Medhat Shehata
Publikováno v:
Cells, Vol 9, Iss 6, p 1484 (2020)
NOTCH signaling represents a promising therapeutic target in chronic lymphocytic leukemia (CLL). We compared the anti-neoplastic effects of the nuclear NOTCH2 inhibitor gliotoxin and the pan-NOTCH γ-secretase inhibitor RO4929097 in primary CLL cells
Externí odkaz:
https://doaj.org/article/9fa36cc823a740d693e92d4114a3a329
Autor:
Rainer Hubmann, Wolfgang Sieghart, Susanne Schnabl, Mohammad Araghi, Martin Hilgarth, Marlies Reiter, Dita Demirtas, Peter Valent, Christoph Zielinski, Ulrich Jäger, Medhat Shehata
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Deregulation of NOTCH2 signaling is implicated in a wide variety of human neoplasias. The current concept of targeting NOTCH is based on using gamma secretase inhibitors (GSI) to regulate the release of the active NOTCH intracellular domain. However,
Externí odkaz:
https://doaj.org/article/5cb20fc27d864c0c9002935297f751e2
Autor:
Peter Valent, Philipp B. Staber, Medhat Shehata, Dita Demirtas, Farghaly Ali, Martin Hilgarth, Rainer Hubmann, Ulrich Jäger, André F. Rendeiro, Mohammad Araghi, Susanne Schnabl, Christian Schmidl, Christoph C. Zielinski
Publikováno v:
Cells
Volume 9
Issue 6
Cells, Vol 9, Iss 1484, p 1484 (2020)
Volume 9
Issue 6
Cells, Vol 9, Iss 1484, p 1484 (2020)
NOTCH signaling represents a promising therapeutic target in chronic lymphocytic leukemia (CLL). We compared the anti-neoplastic effects of the nuclear NOTCH2 inhibitor gliotoxin and the pan-NOTCH &gamma
secretase inhibitor RO4929097 in primary
secretase inhibitor RO4929097 in primary
Autor:
Jaromír Vašíček, Peter Chrenek, Susanne Schnabl, Martin Hilgarth, Ulrich Jäger, Medhat Shehata, Rainer Hubmann, Miroslav Bauer
Publikováno v:
Biotechnology Progress. 34:1278-1289
Rabbits have many hereditary diseases common to humans and are therefore a valuable model for regenerative disease and hematopoietic stem cell (HSC) therapies. Currently, there is no substantial data on the isolation and/or enrichment of rabbit HSCs.
Autor:
Michaela Gruber, Martin Hilgarth, Stefan Kubicek, Edit Porpaczy, Christian Schmidl, Rainer Hubmann, Nikolaus Krall, Anna Ringler, Philipp B. Staber, Christina Taubert, Mohammad Araghi, Dita Demirtas, Gregory I. Vladimer, Oscar Lopez de la Fuente, Medhat Shehata, Giulio Superti-Furga, Berend Snijder, Gregor Hoermann, Tea Pemovska, Cathrin Skrabs, Thomas Krausgruber, Kathrin Runggatscher, Ulrich Jäger, Susanne Schnabl, André F. Rendeiro, Christoph Bock
Publikováno v:
Nature Chemical Biology, 15 (3)
Nature Chemical Biology
Nature Chemical Biology
The Bruton tyrosine kinase (BTK) inhibitor ibrutinib has substantially improved therapeutic options for chronic lymphocytic leukemia (CLL). Although ibrutinib is not curative, it has a profound effect on CLL cells and may create new pharmacologically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8ec57ac57f9b814e4af6f250e81781
https://hdl.handle.net/20.500.11850/328366
https://hdl.handle.net/20.500.11850/328366
Autor:
Susanne Schnabl, Miroslav Bauer, Martin Hilgarth, Maria Tomkova, Andrej Baláži, Medhat Shehata, Lucia Olexikova, Alexander V. Makarevich, Barbora Kulíková, Jaromír Vašíček, Rainer Hubmann, Peter Chrenek, Jozef Čurlej, Michal Kovac
Publikováno v:
New biotechnology. 54
Rabbit mesenchymal stem cells (rMSCs) are promising agents for the preservation of genetic biodiversity in domestic rabbit breeds. However, rMSCs must meet certain requirements to be used for cryopreservation in animal gene banks. Currently, there ar
Autor:
Ulrich Jäger, Katrina Vanura, Susanne Schnabl, Georg Hopfinger, E. Porpaczy, Martin Bilban, Stephan Stilgenbauer, Michael Hallek, Rainer Hubmann, Karin Eigenberger, Dita Demirtas, Martin Hilgarth, Josef D. Schwarzmeier, Medhat Shehata, Ilse Schwarzinger, Alexander Gaiger, Christa Fonatsch, Alexander W. Hauswirth, Daniel Heintel
Publikováno v:
Leukemia. 24:2122-2127
Sequential gene expression profiling during treatment for identification of predictive markers and novel therapeutic targets in chronic lymphocytic leukemia
Autor:
Christoph C. Zielinski, Josef D. Schwarzmeier, Andrea Hoelbl, Ulrich Jaeger, Elena Ponath, Susanne Schnabl, Medhat Shehata, Alexander Gaiger, Sigrun Badrnya, Claudia Lehner, Rainer Hubmann, Markus Duechler, Dita Demirtas, Martin Hilgarth
Publikováno v:
Blood. 116:2513-2521
Evidence suggests that tumor microenvironment is critically involved in supporting survival of chronic lymphocytic leukemia (CLL) cells. However, the molecular mechanisms of this effect and the clinical significance are not fully understood. We appli
Autor:
C. G. Gasché, Martin Hilgarth, S. Göbl, Rudolf Berger, Josef D. Schwarzmeier, Walter Reinisch
Publikováno v:
Europe PubMed Central
To elucidate mechanisms which may be responsible for the haematopoietic insufficiency in hairy cell leukaemia (HCL), we investigated in an autologous in vitro system the influence of haematopoietic growth factors (CSFs) and the effects of hairy cells
Autor:
Martin Hilgarth, Josef D. Schwarzmeier, Medhat Shehata, Markus Duechler, Rainer Hubmann, Andrea Hoelbl
Publikováno v:
Leukemia. 19:260-267
Recently, proteasome inhibitors (PI) have attracted interest as novel anticancer agents in B-cell chronic lymphocytic leukemia (B-CLL). A prominent feature of B-CLL cells is the high expression of CD23, which is closely related to cell survival and i