Zobrazeno 1 - 10
of 353
pro vyhledávání: '"Martin Hart"'
Autor:
Martin Hart, Fabian Kern, Claudia Fecher-Trost, Lena Krammes, Ernesto Aparicio, Annika Engel, Pascal Hirsch, Viktoria Wagner, Verena Keller, Georges Pierre Schmartz, Stefanie Rheinheimer, Caroline Diener, Ulrike Fischer, Jens Mayer, Markus R. Meyer, Veit Flockerzi, Andreas Keller, Eckart Meese
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 4, Pp 935-945 (2024)
Abstract The identification of targetomes remains a challenge given the pleiotropic effect of miRNAs, the limited effects of miRNAs on individual targets, and the sheer number of estimated miRNA–target gene interactions (MTIs), which is around 44,5
Externí odkaz:
https://doaj.org/article/3efe0c622e26455595bea061ca0cb9f0
Autor:
Martin Hart, Caroline Diener, Laetitia Lunkes, Stefanie Rheinheimer, Lena Krammes, Andreas Keller, Eckart Meese
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-14 (2023)
Abstract Background Although a pivotal role of microRNA (miRNA, miR) in the pathogenesis of Huntington’s disease (HD) is increasingly recognized, the molecular functions of miRNAs in the pathomechanisms of HD await further elucidation. One of the m
Externí odkaz:
https://doaj.org/article/0578c66489664e6083912c40e38041c8
Autor:
Caroline Diener, Martin Hart, Claudia Fecher-Trost, Jessica Knittel, Stefanie Rheinheimer, Markus R. Meyer, Jens Mayer, Veit Flockerzi, Andreas Keller, Eckart Meese
Publikováno v:
Cellular & Molecular Biology Letters, Vol 28, Iss 1, Pp 1-16 (2023)
Abstract Among the concepts in biology that are widely taken granted is a potentiated cooperative effect of multiple miRNAs on the same target. This strong hypothesis contrasts insufficient experimental evidence. The quantity as well as the quality o
Externí odkaz:
https://doaj.org/article/6107573b558b458e821e4f0ddff8a018
Autor:
Caroline Diener, Martin Hart, Tim Kehl, Anouck Becker-Dorison, Tanja Tänzer, David Schub, Lena Krammes, Martina Sester, Andreas Keller, Marcus Unger, Barbara Walch-Rückheim, Hans-Peter Lenhof, Eckart Meese
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Parkinson’s disease (PD) emerges as a complex, multifactorial disease. While there is increasing evidence that dysregulated T cells play a central role in PD pathogenesis, elucidation of the pathomechanical changes in related signaling is
Externí odkaz:
https://doaj.org/article/ce961832053e4fdbbe3c6ae514a78196
Autor:
Laura Theobald, Russalina Stroeder, Patrick Melchior, Ioan Iulian Iordache, Tanja Tänzer, Meike Port, Birgit Glombitza, Stefanie Marx, David Schub, Christian Herr, Martin Hart, Nicole Ludwig, Eckart Meese, Yoo‐Jin Kim, Rainer Maria Bohle, Sigrun Smola, Christian Rübe, Erich Franz Solomayer, Barbara Walch‐Rückheim
Publikováno v:
Molecular Oncology, Vol 15, Iss 12, Pp 3559-3577 (2021)
Cervical cancer therapy is still a major clinical challenge, as patients substantially differ in their response to standard treatments, including chemoradiotherapy (CRT). During cervical carcinogenesis, T‐helper (Th)‐17 cells accumulate in the pe
Externí odkaz:
https://doaj.org/article/9d39a3e2e8984294abe5e69d7e568744
Autor:
Wenjuan Yang, Andreas Denger, Caroline Diener, Frederic Küppers, Leticia Soriano-Baguet, Gertrud Schäfer, Archana K. Yanamandra, Renping Zhao, Arne Knörck, Eva C. Schwarz, Martin Hart, Frank Lammert, Leticia Prates Roma, Dirk Brenner, Grigorios Christidis, Volkhard Helms, Eckart Meese, Markus Hoth, Bin Qu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
TNF-related apoptosis inducing ligand (TRAIL) is expressed on cytotoxic T lymphocytes (CTLs) and TRAIL is linked to progression of diabetes. However, the impact of high glucose on TRAIL expression and its related killing function in CTLs still remain
Externí odkaz:
https://doaj.org/article/41dfb74dc93e4233acaa18be90003c70
Autor:
Jennifer Menegatti, Jacqueline Nakel, Youli K. Stepanov, Karolina M. Caban, Nicole Ludwig, Ruth Nord, Thomas Pfitzner, Maryam Yazdani, Monika Vilimova, Tim Kehl, Hans-Peter Lenhof, Stephan E. Philipp, Eckart Meese, Thomas Fröhlich, Friedrich A. Grässer, Martin Hart
Publikováno v:
Cancers, Vol 14, Iss 20, p 5031 (2022)
Background: As microRNA-142 (miR-142) is the only human microRNA gene where mutations have consistently been found in about 20% of all cases of diffuse large B-cell lymphoma (DLBCL), we wanted to determine the impact of miR-142 inactivation on protei
Externí odkaz:
https://doaj.org/article/2c158f0d935a4881b2094ce41bd06c4f
Autor:
Sven Wach, Madeleine Brandl, Hannes Borchardt, Katrin Weigelt, Sabine Lukat, Elke Nolte, Omar Al-Janabi, Martin Hart, Friedrich Grässer, Johannes Giedl, Rudolf Jung, Robert Stöhr, Arndt Hartmann, Verena Lieb, Sabrina Höbel, Anna Peters, Claudia Stäubert, Bernd Wullich, Helge Taubert, Achim Aigner
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 16, Iss , Pp 272-283 (2019)
MIR143 is pathologically downregulated and may function as a tumor suppressor in prostate cancer. Likewise, the urokinase plasminogen activator receptor (UPAR) is overexpressed in prostate carcinoma, representing a negative prognostic marker and puta
Externí odkaz:
https://doaj.org/article/d8d765c582e04b049197e5a16a0b421e
Autor:
Andreas Keller, Martin Hart, Lena Krammes, Tim Kehl, Stefanie Rheinheimer, Martina Sester, Hans-Peter Lenhof, Eckart Meese, Laura Nickl, Barbara Walch-Rueckheim, Caroline Diener, Tanja Taenzer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background In 2016 the first-in-human phase I study of a miRNA-based cancer therapy with a liposomal mimic of microRNA-34a-5p (miR-34a-5p) was closed due to five immune related serious adverse events (SAEs) resulting in four patient deaths. For futur
Externí odkaz:
https://doaj.org/article/1ad56f0ae0fa46b9bdf84c91643829ce
Autor:
Anthony G Gallagher, Martin Hart, David Cleary, Craig Hamilton, Kevin McGlinchey, Patrick Kiely, Brendan P Bunting
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0231979 (2020)
OBJECTIVES:We evaluated a simulation-based training curriculum with quantitatively defined performance benchmarks for utility workers location and excavation of utility services. BACKGROUND:Damaging buried utilities is associated with considerable sa
Externí odkaz:
https://doaj.org/article/dbde15a867e64f1391a1af588cc7ce80