Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Martin Hallbeck"'
Autor:
Tahir Ali, Antonia N. Klein, Keegan McDonald, Lovisa Johansson, Priyanka Ganguli Mukherjee, Martin Hallbeck, Katsumi Doh-ura, Hermann M. Schatzl, Sabine Gilch
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-18 (2023)
Abstract Alzheimer’s disease (AD) is an incurable, progressive and devastating neurodegenerative disease. Pathogenesis of AD is associated with the aggregation and accumulation of amyloid beta (Aβ), a major neurotoxic mediator that triggers neuroi
Externí odkaz:
https://doaj.org/article/4af0705271474c65b716901bfd0d6560
Autor:
Małgorzata Łysiak, Małgorzata Trybuła, Munila Mudaisi, Charlotte Bratthäll, Michael Strandeus, Peter Milos, Martin Hallbeck, Annika Malmström
Publikováno v:
Molecular Oncology, Vol 16, Iss 19, Pp 3436-3451 (2022)
We sought to analyse the androgen receptor (AR) in glioblastoma (GBM) due to the location of the AR gene on chromosome X, often reported with shorter survival and higher prevalence of GBM among males. Copy number (CN) and mRNA expression of AR were t
Externí odkaz:
https://doaj.org/article/337ccc57f9014fe9b50c382e783dedc5
Autor:
Juan F. Reyes, Sara Ekmark-Léwen, Marina Perdiki, Therése Klingstedt, Alana Hoffmann, Emilia Wiechec, Per Nilsson, K. Peter R. Nilsson, Irina Alafuzoff, Martin Ingelsson, Martin Hallbeck
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-20 (2021)
Abstract Alpha-synuclein (α-syn) aggregation is the hallmark pathological lesion in brains of patients with Parkinson’s disease (PD) and related neurological disorders characterized as synucleinopathies. Accumulating evidence now indicates that α
Externí odkaz:
https://doaj.org/article/d3b37dfdd451474997f2e1e5c9a5e227
Autor:
Serge Moudio, Fredrik Rodin, Nazira Jamal Albargothy, Urban Karlsson, Juan F. Reyes, Martin Hallbeck
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
The accumulation of proteinaceous deposits comprised largely of the α-synuclein protein is one of the main hallmarks of Parkinson's disease (PD) and related synucleinopathies. Their progressive development coincides with site-specific phosphorylatio
Externí odkaz:
https://doaj.org/article/9f67a8c12f044408a9929d0843d9ad2b
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
The misfolding of transactive response DNA-binding protein (TDP-43) is a major contributor to the pathogenesis of TDP-43 proteinopathies, including amyotrophic lateral sclerosis and frontotemporal lobar degeneration with TDP-43 inclusions, but also p
Externí odkaz:
https://doaj.org/article/850fdf5fac0f4e2ab39ef57f68985ab9
Autor:
Valerie Sackmann, Maitrayee Sardar Sinha, Christopher Sackmann, Livia Civitelli, Joakim Bergström, Anna Ansell-Schultz, Martin Hallbeck
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Recently, extracellular vesicles (EVs), such as exosomes, have been proposed to play an influential role in the cell-to-cell spread of neurodegenerative diseases, including the intercellular transmission of α-synuclein (α-syn). However, the regulat
Externí odkaz:
https://doaj.org/article/8d411cee54494594a6bd351a57e07b82
Autor:
Jakob Domert, Sahana Bhima Rao, Lotta Agholme, Ann-Christin Brorsson, Jan Marcusson, Martin Hallbeck, Sangeeta Nath
Publikováno v:
Neurobiology of Disease, Vol 65, Iss , Pp 82-92 (2014)
The spreading of pathology through neuronal pathways is likely to be the cause of the progressive cognitive loss observed in Alzheimer's disease (AD) and other neurodegenerative diseases. We have recently shown the propagation of AD pathology via cel
Externí odkaz:
https://doaj.org/article/96c2d315cfd949618e393a8c2edc1f4e
Autor:
Jakob Domert, Christopher Sackmann, Emelie Severinsson, Lotta Agholme, Joakim Bergström, Martin Ingelsson, Martin Hallbeck
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168700 (2016)
Parkinson's disease and other alpha-synucleinopathies are progressive neurodegenerative diseases characterized by aggregates of misfolded alpha-synuclein spreading throughout the brain. Recent evidence suggests that the pathological progression is li
Externí odkaz:
https://doaj.org/article/80c3928369814dd596c3209bf7e764cb
Autor:
Albrecht Stenzinger, Robert Thimme, Ambros J. Beer, Oliver Kohlbacher, Anna Wedell, Michael Bitzer, Mikaela Friedman, Mia Wadelius, Thomas Seufferlein, Per Sikora, Peter Kuhn, Thoas Fioretos, Hans Ehrencrona, Stefan Fröhling, Justus Duyster, Anna Lindstrand, Lars Engstrand, Verena I. Gaidzik, Johan Botling, Melanie Boerries, Lucia Cavelier, Anna Lena Illert, Martin Hallbeck, Michael Akhras, Gisela Helenius, Christopher Schroeder, Jan Budczies, Anders Edsjö, Valtteri Wirta, Carolin Ploeger, Silke Lassmann, Erik Melén, Lars Palmqvist, Maréne Landström, Peter Schirmacher, Lovisa Lovmar, Peter Horak, David Gisselsson, Nisar P. Malek, Lars-Åke Levin, Richard Rosenquist, Konstantin Nikolaou
Publikováno v:
Seminars in Cancer Biology. 84:242-254
Over the last decades, rapid technological and scientific advances have led to a merge of molecular sciences and clinical medicine, resulting in a better understanding of disease mechanisms and the development of novel therapies that exploit specific
Publikováno v:
Scandinavian Journal of Rheumatology. 51:161-163
Lymphadenopathy is a common manifestation of active rheumatic disease, although other causalities, such as infections and malignancies, always need to be taken into account. For rheumatic diseases,...