New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets.

Autor: Robert H E Friesen, Wouter Koudstaal, Martin H Koldijk, Gerrit Jan Weverling, Just P J Brakenhoff, Peter J Lenting, Koert J Stittelaar, Albert D M E Osterhaus, Ronald Kompier, Jaap Goudsmit

Publikováno v: PLoS ONE, Vol 5, Iss 2, p e9106 (2010)

BackgroundThe urgent medical need for innovative approaches to control influenza is emphasized by the widespread resistance of circulating subtype H1N1 viruses to the leading antiviral drug oseltamivir, the pandemic threat posed by the occurrences of

Externí odkaz: https://doaj.org/article/a18d9b465c634aafa91631ed935c70d4

A common antigenic motif recognized by naturally occurring human VH5–51/VL4–1 anti-tau antibodies with distinct functionalities

Autor: Jeroen van Ameijde, Trevin Holland, Hanna Inganäs, Ian A. Wilson, Gabriel Pascual, Hanneke Verveen, Roosmarijn Janson, Donata de Marco, Jeroen J.M. Hoozemans, Esther J. M. Stoop, Stefan Steinbacher, Renske Taggenbrock, Berdien Siregar, Rosa Crespo, Jay Wadia, Wouter Koudstaal, Margot van Winsen, Koen Dockx, Adrian Constantin Apetri, Jaap Goudsmit, Wenli Yu, David Zuijdgeest, Marianne Borgers, Jarek Juraszek, Heng Zhang, Elissa Keogh, Kristof Van Kolen, Kimberley Ummenthum, Martin H. Koldijk, Marc Mercken, Xueyong Zhu, Els C. M. Brinkman-Van der Linden, Michael Mrosek

Publikováno v: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Apetri, A, Crespo, R, Juraszek, J, Pascual, G, Janson, R, Zhu, X, Zhang, H, Keogh, E, Holland, T, Wadia, J, Verveen, H, Siregar, B, Mrosek, M, Taggenbrock, R, Ameijde, J, Inganäs, H, van Winsen, M, Koldijk, M H, Zuijdgeest, D, Borgers, M, Dockx, K, Stoop, E J M, Yu, W, Brinkman-van der Linden, E C, Ummenthum, K, van Kolen, K, Mercken, M, Steinbacher, S, de Marco, D, Hoozemans, J J, Wilson, I A, Koudstaal, W & Goudsmit, J 2018, ' A common antigenic motif recognized by naturally occurring human V H 5-51/V L 4-1 anti-tau antibodies with distinct functionalities ', Acta Neuropathologica Communinications, vol. 6, no. 1, 43, pp. 43 . https://doi.org/10.1186/s40478-018-0543-z, https://doi.org/10.1186/s40478-018-0543-z
Acta Neuropathologica Communinications, 6(1):43. BioMed Central

Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer's Disease (AD). By interrogating IgG + memory B cells from asymptomatic donors with tau peptides, we have identified two somatically mutated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0cc3ef318c798400926689fc83aaa11
http://link.springer.com/article/10.1186/s40478-018-0543-z

PER.C6® cells as a serum-free suspension cell platform for the production of high titer poliovirus: A potential low cost of goods option for world supply of inactivated poliovirus vaccine

Autor: Hanneke Schuitemaker, Lewis John Alfred, Barbara Petronella Sanders, F. Uytdehaag, Jaap Goudsmit, Martin H. Koldijk, Diana Edo-Matas, Wilfried A.M. Bakker, Jerome Custers, Vincent Klaren, Alfred Luitjens, Marije Turk

Publikováno v: Vaccine, 31(5), 850-856. Elsevier BV

There are two highly efficacious poliovirus vaccines: Sabin's live-attenuated oral polio vaccine (OPV) and Salk's inactivated polio vaccine (IPV). OPV can be made at low costs per dose and is easily administrated. However, the major drawback is the f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb218d13cf966af08f5e085d5a17b66d
https://doi.org/10.1016/j.vaccine.2012.10.070

Serum-free transient protein production system based on adenoviral vector and PER.C6 technology: high yield and preserved bioactivity

Autor: R. van der Vlugt, Lennart Holterman, Jaap Goudsmit, Menzo J. E. Havenga, Martin H. Koldijk, Jorn Kaspers, Guus Hateboer, E. Heemskerk, Ronald Vogels, Shirley Smits, I. Melis, K. Brouwer, Govert Johan Schouten

Publikováno v: Biotechnology and Bioengineering
Biotechnology and bioengineering, 100(2), 273-283. Wiley-VCH Verlag

Stable E1 transformed cells, like PER.C6, are able to grow at scale and to high cell densities. E1‐deleted adenoviruses replicate to high titer in PER.C6 cells whereas subsequent deletion of E2A from the vector results in absence of replication in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da3a32e83ef4ce79caf18ab0d9255a46
https://doi.org/10.1002/bit.21757

Inactivated Viral Vaccines

Autor: Martin H. Koldijk, Hanneke Schuitemaker, Barbara Petronella Sanders

Publikováno v: Vaccine Analysis: Strategies, Principles, and Control ISBN: 9783662450239

Inactivated vaccines have been used for over a century to induce protection against viral pathogens. This established approach of vaccine production is relatively straightforward to achieve and there is an augmented safety profile as compared to thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8019c0a1cba05dbfc8a0f523cc11140
https://doi.org/10.1007/978-3-662-45024-6_2