A pan-influenza monoclonal antibody neutralizes H5 strains and prophylactically protects through intranasal administration

Autor: Anna L. Beukenhorst, Jacopo Frallicciardi, Keira L. Rice, Martin H. Koldijk, Joana C. Moreira de Mello, Jaco M. Klap, Christoforos Hadjichrysanthou, Clarissa M. Koch, Kelly A. S. da Costa, Nigel Temperton, Babette A. de Jong, Helene Vietsch, Bertjan Ziere, Boris Julg, Wouter Koudstaal, Jaap Goudsmit

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)

Abstract Avian A(H5N1) influenza virus poses an elevated zoonotic threat to humans, and no pharmacological products are currently registered for fast-acting pre-exposure protection in case of spillover leading to a pandemic. Here, we show that an epi

Externí odkaz: https://doaj.org/article/b85d0a98851e4b6a93bc94df6dc119e5

A common antigenic motif recognized by naturally occurring human VH5–51/VL4–1 anti-tau antibodies with distinct functionalities

Autor: Jeroen van Ameijde, Trevin Holland, Hanna Inganäs, Ian A. Wilson, Gabriel Pascual, Hanneke Verveen, Roosmarijn Janson, Donata de Marco, Jeroen J.M. Hoozemans, Esther J. M. Stoop, Stefan Steinbacher, Renske Taggenbrock, Berdien Siregar, Rosa Crespo, Jay Wadia, Wouter Koudstaal, Margot van Winsen, Koen Dockx, Adrian Constantin Apetri, Jaap Goudsmit, Wenli Yu, David Zuijdgeest, Marianne Borgers, Jarek Juraszek, Heng Zhang, Elissa Keogh, Kristof Van Kolen, Kimberley Ummenthum, Martin H. Koldijk, Marc Mercken, Xueyong Zhu, Els C. M. Brinkman-Van der Linden, Michael Mrosek

Publikováno v: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Apetri, A, Crespo, R, Juraszek, J, Pascual, G, Janson, R, Zhu, X, Zhang, H, Keogh, E, Holland, T, Wadia, J, Verveen, H, Siregar, B, Mrosek, M, Taggenbrock, R, Ameijde, J, Inganäs, H, van Winsen, M, Koldijk, M H, Zuijdgeest, D, Borgers, M, Dockx, K, Stoop, E J M, Yu, W, Brinkman-van der Linden, E C, Ummenthum, K, van Kolen, K, Mercken, M, Steinbacher, S, de Marco, D, Hoozemans, J J, Wilson, I A, Koudstaal, W & Goudsmit, J 2018, ' A common antigenic motif recognized by naturally occurring human V H 5-51/V L 4-1 anti-tau antibodies with distinct functionalities ', Acta Neuropathologica Communinications, vol. 6, no. 1, 43, pp. 43 . https://doi.org/10.1186/s40478-018-0543-z, https://doi.org/10.1186/s40478-018-0543-z
Acta Neuropathologica Communinications, 6(1):43. BioMed Central

Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer's Disease (AD). By interrogating IgG + memory B cells from asymptomatic donors with tau peptides, we have identified two somatically mutated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0cc3ef318c798400926689fc83aaa11
http://link.springer.com/article/10.1186/s40478-018-0543-z

Common antigenic motif recognized by human VH5-51/VL4-1 tau antibodies with distinct functionalities

Autor: Margot van Winsen, Hanneke Verveen, Heng Zhang, Jarek Juraszek, Renske Taggenbrock, Els C. M. Brinkman-Van der Linden, Elissa Keogh, Gabriel Pascual, Stefan Steinbacher, Berdien Siregar, Jaap Goudsmit, Wenli Yu, Michael Mrosek, Adrian Constantin Apetri, Jeroen van Ameijde, Marianne Borgers, Martin H. Koldijk, Wouter Koudstaal, Jay Wadia, Trevin Holland, Kristof Van Kolen, Xueyong Zhu, Donata de Marco, Kimberley Ummenthum, Esther J. M. Stoop, Hanna Inganäs, Koen Dockx, Marc Mercken, Jeroen J.M. Hoozemans, Rosa Crespo, Roosmarijn Janson, Ian A. Wilson, David Zuijdgeest

Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer’s Disease (AD). By interrogating IgG+ memory B cells from asymptomatic donors with tau peptides, we have identified two somatically mutated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f55d99202634ace50c06b8d45d8562

Pre- and postexposure use of human monoclonal antibody against H5N1 and H1N1 influenza virus in mice: viable alternative to oseltamivir

Autor: Wouter Koudstaal, Lisette A. H. M. Cornelissen, Just P. J. Brakenhoff, Gerrit Jan Weverling, Martin H. Koldijk, Robert H. E. Friesen, Jaap Goudsmit

Publikováno v: Journal of infectious diseases, 200(12), 1870-1873. Oxford University Press
The Journal of Infectious Diseases, 200(12), 1870-1873
The Journal of Infectious Diseases
The Journal of Infectious Diseases 200 (2009) 12

New strategies to prevent and treat influenza virus infections are urgently needed. A recently discovered class of monoclonal antibodies (mAbs) neutralizing an unprecedented spectrum of influenza virus subtypes may have the potential for future use i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c179a75e73d84cb8d9614bfc8a314b
https://doi.org/10.1086/648378

A sensitive cell-based assay for the detection of residual infectious West Nile virus

Autor: Lewis John Alfred, Jaap Goudsmit, Giuseppe Marzio, C. Ophorst, Martin H. Koldijk, Gerrit Jan Weverling, F. Uytdehaag, Linda Gijsbers, Johannes A. Bogaards, Stefan Kostense, M Ter Haak, Just P. J. Brakenhoff, M de Vocht, J.Y. Guichoux

Publikováno v: Koldijk, M H, Bogaards, J A, Kostense, S, de Vocht, M, Gijsbers, L, ter Haak, M, Ophorst, C, Brakenhoff, J P J, Weverling, G J, Guichoux, J Y, UytdeHaag, F, Lewis, J, Goudsmit, J & Marzio, G 2007, ' A sensitive cell-based assay for the detection of residual infectious West Nile virus ', Vaccine, vol. 25, no. 39-40, pp. 6872-6881 . https://doi.org/10.1016/j.vaccine.2007.07.011
Vaccine, 25(39-40), 6872-6881. Elsevier BV

Ensuring complete viral inactivation is critical for the safety of vaccines based on an inactivated virus. Detection of residual infectious virus is dependent on sensitivity of the assay, sample volume analyzed and the absence of interference with vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318dd496eff06edd49f673314200b7b3
https://doi.org/10.1016/j.vaccine.2007.07.011