Výsledky vyhledávání - "Martin Gunthorpe"

The unique turret region of Kv3 channels governs the mechanism of action of highly specific positive allosteric modulators

Autor: Manuel Covarrubias, Qiansheng Liang, Lianteng Zhi, Leonardo Cirqueira, Nadia Pilati, Agostino Marasco, Martin Gunthorpe, Giuseppe Alvaro, Charles Large, Werner Treptow

Small-molecule modulators of diverse voltage-gated K+ (Kv) channels may help treat severe neurological disorders. However, the development of selective modulators requires an understanding of their mechanism-of-action (MoA). We applied an orthogonal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d0ae1e38f32448f117e7b54ce55693a
https://doi.org/10.21203/rs.3.rs-2798797/v1

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Timing is everything: structural insights into the disease-linked Kv3 channels controlling fast action-potential firing in the brain

Autor: Martin Gunthorpe

Publikováno v: Nature communications. 13(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f032e3c18939c5ae0fa584aa13d1ffb8
https://pubmed.ncbi.nlm.nih.gov/35840580

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New insights into the molecular basis of allosteric activation of the TMEM16A channel and consequences for the control of vascular tone

Autor: Rumaitha Al Hosni, Emilio Agostinelli, Zeki Ilkan, Lara F. Scofano, Kathryn Acheson, Andrew MacDonald, Dean Rivers, Martin Gunthorpe, Frances Platt, Paolo Tammaro

Publikováno v: Biophysical Journal. 122:458a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8728cc1e0ed1560ff23e2446844da0c
https://doi.org/10.1016/j.bpj.2022.11.2463

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