Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Martin Grininger"'
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Modular polyketide synthases (PKSs) play a vital role in the biosynthesis of complex natural products with pharmaceutically relevant properties. Their modular architecture makes them an attractive target for engineering to produce platform c
Externí odkaz:
https://doaj.org/article/07a55013b167453db446ff98b444e18a
Autor:
Elnaz Khalili Samani, Amy C. Chen, Jennifer W. Lou, David L. Dai, Alexander F. A. Keszei, Guihong Tan, Charles Boone, Martin Grininger, Mohammad T. Mazhab-Jafari
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Acyl carrier protein (ACP) is the work horse of polyketide (PKS) and fatty acid synthases (FAS) and acts as a substrate shuttling domain in these mega enzymes. In fungi, FAS forms a 2.6 MDa symmetric assembly with six identical copies of FAS
Externí odkaz:
https://doaj.org/article/426835cd27af4b18b2741bd4d0b37a91
Autor:
Xu Han, Cecilia D'Angelo, Ainara Otamendi, Javier O. Cifuente, Elisa de Astigarraga, Borja Ochoa-Lizarralde, Martin Grininger, Francoise H. Routier, Marcelo E. Guerin, Jana Fuehring, Oier Etxebeste, Sean R. Connell
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Invasive aspergillosis is one of the most serious clinical invasive fungal infections, resulting in a high case fatality rate among immunocompromised patients. The disease is caused by saprophytic molds in the genus Aspergillus, including As
Externí odkaz:
https://doaj.org/article/232e426a0a684ce694dd55e5be755b6b
Autor:
Florian Altegoer, Tessa E. F. Quax, Paul Weiland, Phillip Nußbaum, Pietro I. Giammarinaro, Megha Patro, Zhengqun Li, Dieter Oesterhelt, Martin Grininger, Sonja-Verena Albers, Gert Bange
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Signal transduction via phosphorylated CheY is conserved in bacteria and archaea. In this study, the authors employ structural biochemistry combined with cell biology to delineate the mechanism of CheY recognition by the adaptor protein CheF.
Externí odkaz:
https://doaj.org/article/b6454e42da1343c1be0098625eed36d3
Autor:
Maja Klaus, Emanuele Rossini, Andreas Linden, Karthik S. Paithankar, Matthias Zeug, Zoya Ignatova, Henning Urlaub, Chaitan Khosla, Jürgen Köfinger, Gerhard Hummer, Martin Grininger
Publikováno v:
JACS Au, Vol 1, Iss 12, Pp 2162-2171 (2021)
Externí odkaz:
https://doaj.org/article/cc5a4084c1844ff7be0bc18a8b97db80
Publikováno v:
Synthetic and Systems Biotechnology, Vol 7, Iss 4, Pp 1044-1045 (2022)
Externí odkaz:
https://doaj.org/article/a0bf1b78cdeb41389b46e461a4638733
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Tsetse flies are the transmitting vector of trypanosomes causing human sleeping sickness and animal trypanosomiasis in sub-saharan Africa. 3-alkylphenols are used as attractants in tsetse fly traps to reduce the spread of the disease. Here w
Externí odkaz:
https://doaj.org/article/baea499fd6f146c7874810cf2983284d
Autor:
Mirko Joppe, Edoardo D'Imprima, Nina Salustros, Karthik S. Paithankar, Janet Vonck, Martin Grininger, Werner Kühlbrandt
Publikováno v:
IUCrJ, Vol 7, Iss 2, Pp 220-227 (2020)
Single-particle electron cryo-microscopy (cryoEM) has undergone a `resolution revolution' that makes it possible to characterize megadalton (MDa) complexes at atomic resolution without crystals. To fully exploit the new opportunities in molecular mic
Externí odkaz:
https://doaj.org/article/66fab2648bb94b1d8826f3ef9dbd9878
Publikováno v:
Biotechnology for Biofuels, Vol 11, Iss 1, Pp 1-12 (2018)
Abstract Background The ideal biofuel should not only be a regenerative fuel from renewable feedstocks, but should also be compatible with the existing fuel distribution infrastructure and with normal car engines. As the so-called drop-in biofuel, th
Externí odkaz:
https://doaj.org/article/8b0f1fdfbd994e48abd885b1c78fc0f0
Autor:
Manuel Fischer, Martin Grininger
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 1204-1211 (2017)
Megasynthases are large multienzyme proteins that produce a plethora of important natural compounds by catalyzing the successive condensation and modification of precursor units. Within the class of megasynthases, polyketide synthases (PKS) are respo
Externí odkaz:
https://doaj.org/article/90c1cbba7c2e4eb9bae9a0b50697089e