Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Martin Gellert"'
Autor:
Sandeep Dayal, Jakub Nedbal, Philip Hobson, Alison M Cooper, Hannah J Gould, Martin Gellert, Gary Felsenfeld, David J Fear
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24571 (2011)
Antibodies are assembled by a highly orchestrated series of recombination events during B cell development. One of these events, class switch recombination, is required to produce the IgG, IgE and IgA antibody isotypes characteristic of a secondary i
Externí odkaz:
https://doaj.org/article/fcfbb95a08de43cea8d5df8eb6b5a4dd
Akademický článek
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Autor:
Christopher J. Buehl, Noah J. Goff, Steven W. Hardwick, Martin Gellert, Tom L. Blundell, Wei Yang, Amanda K. Chaplin, Katheryn Meek
Publikováno v:
Molecular Cell. 83:698-714.e4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd8108b4b7e39bb1b3f12e50aacf579c
https://doi.org/10.1016/j.molcel.2023.01.012
https://doi.org/10.1016/j.molcel.2023.01.012
Publikováno v:
Nature structural & molecular biology
Nature structural & molecular biology, vol 27, iss 2
Nature structural & molecular biology, vol 27, iss 2
The RAG1-RAG2 recombinase (RAG) cleaves DNA to initiate V(D)J recombination, but RAG also belongs to the RNH-type transposase family. To learn how RAG-catalyzed transposition is inhibited in developing lymphocytes, we determined the structure of a DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b238122885a9299e61148e3fb4e896e
http://europepmc.org/articles/PMC8291384
http://europepmc.org/articles/PMC8291384
Autor:
Christopher J. Buehl, Noah J. Goff, Steven W. Hardwick, Martin Gellert, Tom L. Blundell, Wei Yang, Amanda K. Chaplin, Katheryn Meek
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f07e46878563e160a2ad5a6213b8e94e
https://doi.org/10.2139/ssrn.4069036
https://doi.org/10.2139/ssrn.4069036
Publikováno v:
Curr Opin Struct Biol
RAG1/2 (RAG) is an RNH-type DNA recombinase specially evolved to initiate V(D)J gene rearrangement for generating the adaptive immune response in jawed vertebrates. After decades of frustration with little mechanistic understanding of RAG, the crysta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d925bece6c4458d97d5a2b785dd3167a
https://pubmed.ncbi.nlm.nih.gov/34245989
https://pubmed.ncbi.nlm.nih.gov/34245989
Autor:
Xiang Xu, Martin Gellert, Jiansen Jiang, Joyce C. Cheung, Tara Fox, Xuemin Chen, Yun Chen, Natalia de Val, Huaibin Wang, Wei Yang
Phosphatidylinositol 3-kinase-related kinases (PIKKs) are composed of conserved FAT and kinase domains (FATKIN) along with varied solenoid structures made of HEAT repeats. These kinases are activated in response to cellular stress signals, but the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::befc0f68f4b405b12e4c009fe902350e
https://doi.org/10.1101/2020.10.19.346148
https://doi.org/10.1101/2020.10.19.346148
Autor:
Xuemin Chen, Xiang Xu, Martin Gellert, Yun Chen, Joyce C. Cheung, Tara Fox, Wei Yang, Jiansen Jiang, Natalia de Val, Huaibin Wang
Publikováno v:
Molecular cell. 81(4)
Summary DNA-dependent protein kinase (DNA-PK), like all phosphatidylinositol 3-kinase-related kinases (PIKKs), is composed of conserved FAT and kinase domains (FATKINs) along with solenoid structures made of HEAT repeats. These kinases are activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143692b9e96bb029c1f364ca22d4db92
https://pubmed.ncbi.nlm.nih.gov/33606972
https://pubmed.ncbi.nlm.nih.gov/33606972
Autor:
Lan Liu, Xuemin Chen, Jun Li, Huaibin Wang, Christopher J. Buehl, Noah J. Goff, Katheryn Meek, Wei Yang, Martin Gellert
Publikováno v:
Mol Cell
The DNA-dependent protein kinase (DNA-PK) initially protects broken DNA ends, but then promotes their processing during non-homologous end-joining (NHEJ). Before ligation by NHEJ, DNA hairpin ends generated during V(D)J recombination must be opened b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52a4d4917e9732c5d02e1e4b9d99071
https://doi.org/10.1016/j.molcel.2021.11.025
https://doi.org/10.1016/j.molcel.2021.11.025
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 77:C30-C30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b748b3cf17281cf40161f1583581927d
https://doi.org/10.1107/s0108767321096471
https://doi.org/10.1107/s0108767321096471