Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Martin G. Sirois"'
Autor:
Charlotte Burelle, Valentin Clapatiuc, Sonia Deschênes, Alexanne Cuillerier, Marine De Loof, Marie-Ève Higgins, Hugues Boël, Caroline Daneault, Billie Chouinard, Marie-Élaine Clavet, Nolwenn Tessier, Isabelle Croteau, Geneviève Chabot, Catherine Martel, Martin G. Sirois, Sylvie Lesage, Yan Burelle, Matthieu Ruiz
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Abstract Lean patients with NAFLD may develop cardiac complications independently of pre-existent metabolic disruptions and comorbidities. To address the underlying mechanisms independent of the development of obesity, we used a murine model of hepat
Externí odkaz:
https://doaj.org/article/88f52e0afd2145fc82e7f585470ab99c
Autor:
Pramod Sahadevan, Dharmendra Dingar, Sherin A. Nawaito, Reshma S. Nair, Joëlle Trépanier, Fatiha Sahmi, Yanfen Shi, Marc‐Antoine Gillis, Martin G. Sirois, Sylvain Meloche, Jean‐Claude Tardif, Bruce G. Allen
Publikováno v:
Physiological Reports, Vol 12, Iss 11, Pp n/a-n/a (2024)
Abstract ERK3/MAPK6 activates MAP kinase‐activated protein kinase (MK)‐5 in selected cell types. Male MK5 haplodeficient mice show reduced hypertrophy and attenuated increase in Col1a1 mRNA in response to increased cardiac afterload. In addition,
Externí odkaz:
https://doaj.org/article/dc8134f580334f129f6013b0c2a971fd
Autor:
Benjamin L. Dumont, Paul-Eduard Neagoe, Elcha Charles, Louis Villeneuve, Jean-Claude Tardif, Agnès Räkel, Michel White, Martin G. Sirois
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1674 (2024)
Type 2 diabetes (T2D) is characterized by low-grade inflammation. Low-density neutrophils (LDNs) represent normally less than 2% of total neutrophils but increase in multiple pathologies, releasing inflammatory cytokines and neutrophil extracellular
Externí odkaz:
https://doaj.org/article/cdceb70ab3b9441b86d2e28c038043f4
Autor:
Catherine Lapointe, Laurence Vincent, Hugo Giguère, Mannix Auger‐Messier, Adel Schwertani, Denan Jin, Shinji Takai, Gunnar Pejler, Martin G. Sirois, Hanna Tinel, Stefan Heitmeier, Pedro D'Orléans‐Juste
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 4 (2023)
Background Deep vein thrombosis (DVT) is the primary cause of pulmonary embolism and the third most life‐threatening cardiovascular disease in North America. Post‐DVT anticoagulants, such as warfarin, heparin, and direct oral anticoagulants, redu
Externí odkaz:
https://doaj.org/article/ea76380eae2e426983f2bb85c0adcfaf
Autor:
Zoe White, Marine Theret, Nadia Milad, Lin Wei Tung, William Wei‐Han Chen, Martin G. Sirois, Fabio Rossi, Pascal Bernatchez
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 1, Pp 544-560 (2022)
Abstract Background Muscular dystrophy (MD) causes muscle wasting and is often lethal in patients due to a lack of proven therapies. In contrast, mouse models of MD are notoriously mild. We have previously shown severe human‐like muscle pathology i
Externí odkaz:
https://doaj.org/article/1734f6d867e74b1188de0ce7c5e14a22
Autor:
Elcha Charles, Benjamin L. Dumont, Steven Bonneau, Paul-Eduard Neagoe, Louis Villeneuve, Agnès Räkel, Michel White, Martin G. Sirois
Publikováno v:
BMC Immunology, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background Neutrophils induce the synthesis and release of angiopoietin 1 (Ang1), a cytosolic growth factor involved in angiogenesis and capable of inducing several pro-inflammatory activities in neutrophils. Neutrophils also synthesize and
Externí odkaz:
https://doaj.org/article/cdf33a1275f14f7f9e1c14bca8663e00
Autor:
Corrado De Marco, Brian L. Claggett, Simon deDenus, Michael R. Zile, Thao Huynh, Akshay S. Desai, Martin G. Sirois, Scott D. Solomon, Bertram Pitt, Jean L. Rouleau, Marc A. Pfeffer, Eileen O'Meara
Publikováno v:
ESC Heart Failure, Vol 8, Iss 2, Pp 1130-1138 (2021)
Abstract Aims Diabetes mellitus (DM) is common in heart failure with preserved ejection fraction (HFpEF). Patients with DM and heart failure with reduced ejection fraction have higher levels of cardiac, profibrotic, and proinflammatory biomarkers rel
Externí odkaz:
https://doaj.org/article/b070388439fb4ff99e7b2abea15e1756
Autor:
William Beaubien-Souligny, MD, Paul-Eduard Neagoe, PhD, Daniel Gagnon, PhD, André Y. Denault, MD, PhD, Martin G. Sirois, PhD
Publikováno v:
CJC Open, Vol 2, Iss 2, Pp 39-48 (2020)
Background: The intensity of inflammatory response triggered by cardiopulmonary bypass (CPB) during cardiac surgery has been associated with adverse outcomes. Neutrophils might contribute to organ injury through the liberation of DNA histone-based st
Externí odkaz:
https://doaj.org/article/25aaba0c2684471d96fb95b0975c8ab2
Autor:
Steven Bonneau, Caroline Landry, Stéphanie Bégin, Damien Adam, Louis Villeneuve, Marie-Élaine Clavet-Lanthier, Ariane Dasilva, Elcha Charles, Benjamin L. Dumont, Paul-Eduard Neagoe, Emmanuelle Brochiero, Ahmed Menaouar, Basil Nasir, Louis-Mathieu Stevens, Pasquale Ferraro, Nicolas Noiseux, Martin G. Sirois
Publikováno v:
Cells, Vol 11, Iss 21, p 3420 (2022)
Primary graft dysfunction (PGD) is characterized by alveolar epithelial and vascular endothelial damage and inflammation, lung edema and hypoxemia. Up to one-third of recipients develop the most severe form of PGD (Grade 3; PGD3). Animal studies sugg
Externí odkaz:
https://doaj.org/article/db7196afe4074163ab0348d25ec5cd89
Autor:
Matthieu Ruiz, Maya Khairallah, Dharmendra Dingar, George Vaniotis, Ramzi J. Khairallah, Benjamin Lauzier, Simon Thibault, Joëlle Trépanier, Yanfen Shi, Annie Douillette, Bahira Hussein, Sherin Ali Nawaito, Pramod Sahadevan, Albert Nguyen, Fatiha Sahmi, Marc‐Antoine Gillis, Martin G. Sirois, Matthias Gaestel, William C. Stanley, Céline Fiset, Jean‐Claude Tardif, Bruce G. Allen
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 4 (2021)
Background Mitogen‐activated protein kinase–activated protein kinase‐2 (MK2) is a protein serine/threonine kinase activated by p38α/β. Herein, we examine the cardiac phenotype of pan MK2‐null (MK2−/−) mice. Methods and Results Survival
Externí odkaz:
https://doaj.org/article/f621d6d646c848bc8cfc1f57645591d9