Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Martin G. Belinsky"'
Autor:
Shuai Ye, Dinara Sharipova, Marya Kozinova, Lilli Klug, Jimson D’Souza, Martin G. Belinsky, Katherine J. Johnson, Margret B. Einarson, Karthik Devarajan, Yan Zhou, Samuel Litwin, Michael C. Heinrich, Ronald DeMatteo, Margaret von Mehren, James S. Duncan, Lori Rink
Publikováno v:
JCI Insight, Vol 6, Iss 2 (2021)
Management of gastrointestinal stromal tumors (GISTs) has been revolutionized by the identification of activating mutations in KIT and PDGFRA and clinical application of RTK inhibitors in advanced disease. Stratification of GISTs into molecularly def
Externí odkaz:
https://doaj.org/article/bc77aa077101497c8a5b94060a37a94d
Autor:
Martin G. Belinsky, Kathy Q. Cai, Yan Zhou, Biao Luo, Jianming Pei, Lori Rink, Margaret von Mehren
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-11 (2017)
Abstract Background Most gastrointestinal stromal tumors (GISTs) harbor mutually exclusive gain of function mutations in the receptor tyrosine kinase (RTK) KIT (70–80%) or in the related receptor PDGFRA (~10%). These GISTs generally respond well to
Externí odkaz:
https://doaj.org/article/9eee5c1bb5b142d7958c1fdf045c394f
Publikováno v:
Frontiers in Oncology, Vol 3 (2013)
Gastrointestinal stromal tumors (GISTs) in adults are generally driven by somatic gain-of-function mutations in KIT or PDGFRA, and biological therapies targeted to these receptor tyrosine kinases comprise part of the treatment regimen for metastatic
Externí odkaz:
https://doaj.org/article/2748e3dd4325417f9827bc94b77e789b
Autor:
Lori Rink, Margaret von Mehren, Andrew K. Godwin, Yan Zhou, Karthik Devarajan, Lawrence Gersz, Martin G. Belinsky, Harsh B. Pathak, Phillip Zook
Cleaved caspase-3 is enhanced in combination-treated tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80539c16c059f6de546bd046a40fb9fb
https://doi.org/10.1158/1078-0432.22465832
https://doi.org/10.1158/1078-0432.22465832
Autor:
Lori Rink, Margaret von Mehren, Andrew K. Godwin, Yan Zhou, Karthik Devarajan, Lawrence Gersz, Martin G. Belinsky, Harsh B. Pathak, Phillip Zook
Purpose: Gastrointestinal stromal tumors (GIST) generally harbor activating mutations in the receptor tyrosine kinase KIT or in the related platelet-derived growth factor receptor alpha (PDGFRA). GIST treated with imatinib mesylate or second-line the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b45a66f944fac0ac581e2f16a5b0d7a
https://doi.org/10.1158/1078-0432.c.6526160
https://doi.org/10.1158/1078-0432.c.6526160
Autor:
Lori Rink, Margaret von Mehren, Andrew K. Godwin, Yan Zhou, Karthik Devarajan, Lawrence Gersz, Martin G. Belinsky, Harsh B. Pathak, Phillip Zook
Supplementary Figure Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297e62aed4586a7bd3e90045bbbae5db
https://doi.org/10.1158/1078-0432.22465829.v1
https://doi.org/10.1158/1078-0432.22465829.v1
Autor:
Lori Rink, Margaret von Mehren, Andrew K. Godwin, Yan Zhou, Karthik Devarajan, Lawrence Gersz, Martin G. Belinsky, Harsh B. Pathak, Phillip Zook
IC50 and IC80 values calculated from viability data after treatment with single agents or combination (3:1 molar ratio of MK-2206:IM).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6de656f08cb2474e04c587fbcc3e807
https://doi.org/10.1158/1078-0432.22465826
https://doi.org/10.1158/1078-0432.22465826
Autor:
Lori Rink, Margaret von Mehren, Andrew K. Godwin, Yan Zhou, Karthik Devarajan, Lawrence Gersz, Martin G. Belinsky, Harsh B. Pathak, Phillip Zook
CI values determined using CalcuSyn.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719a46af983a053301da7773c8b4f5a0
https://doi.org/10.1158/1078-0432.22465823.v1
https://doi.org/10.1158/1078-0432.22465823.v1
Autor:
Gary D. Kruh, Martin G. Belinsky, Andres J. Klein-Szanto, Zhe-Sheng Chen, Heiner Westphal, Alex Grinberg, Yehong Kuang, Olivia Ngo, Joely D. Jacobs, Emmanuelle Nicolas, Chelsy Paulose, Timothy Churchill, Elizabeth A. Hopper-Borge
Supplementary Figure Legend from Contribution of Abcc10 (Mrp7) to In Vivo Paclitaxel Resistance as Assessed in Abcc10−/− Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad49008ffad2c952ce3cadde93b6fc3
https://doi.org/10.1158/0008-5472.22387608
https://doi.org/10.1158/0008-5472.22387608
Autor:
Gary D. Kruh, Martin G. Belinsky, Andres J. Klein-Szanto, Zhe-Sheng Chen, Heiner Westphal, Alex Grinberg, Yehong Kuang, Olivia Ngo, Joely D. Jacobs, Emmanuelle Nicolas, Chelsy Paulose, Timothy Churchill, Elizabeth A. Hopper-Borge
Supplementary Figure 1 from Contribution of Abcc10 (Mrp7) to In Vivo Paclitaxel Resistance as Assessed in Abcc10−/− Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c7df37c54c64a45d90c056893e1f41
https://doi.org/10.1158/0008-5472.22387611.v1
https://doi.org/10.1158/0008-5472.22387611.v1