Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Martin G, Schwacha"'
Publikováno v:
Cells, Vol 10, Iss 7, p 1646 (2021)
We previously reported an early surge in high mobility group box protein 1 (HMGB1) levels in a polytrauma (PT) rat model. This study investigates the association of HMGB1 levels in mediating PT associated dysregulated immune responses and its influen
Externí odkaz:
https://doaj.org/article/dad9d9f066544a8e869431fefbde2440
Autor:
Meenakshi Rani, Martin G Schwacha
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179015 (2017)
BACKGROUND:Burn-induced inflammation leads to impaired immune responses resulting in increased morbidity and mortality. T-cells are central in the immune response and circulating CD4 and CD8 T-cells have been used to evaluate immune status; however,
Externí odkaz:
https://doaj.org/article/217b2ab8a1d3460a9149c3aa78b97759
Myeloid-Derived Suppressor Cells (MDSCs) and the Immunoinflammatory Response to Injury (Mini Review)
Publikováno v:
Shock. 56:658-666
Myeloid-derived suppressor cells (MDSCs) are a heterogenous population of immature myeloid cells hallmarked by their potent immunosuppressive function in a vast array of pathologic conditions. MDSCs have recently been shown to exhibit marked expansio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554cb920d4550e92a13d9cf91ada17b5
https://doi.org/10.1097/shk.0000000000001795
https://doi.org/10.1097/shk.0000000000001795
Autor:
Martin G Schwacha, Meenakshi Rani, Susannah E Nicholson, Aaron M Lewis, Travis L Holloway, Salvador Sordo, Andrew P Cap
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158993 (2016)
Gamma delta T-cells have been shown to be important to the early immunoinflammatory response to injury, independent of infection. This unique T-cell population acts to regulate cell trafficking and the release of cytokines and growth factors. We prop
Externí odkaz:
https://doaj.org/article/39480f1a58274fff9dfb17e50f80e53f
Autor:
Brian J. Eastridge, Taylor R Johnson, David M. Burmeister, Martin G. Schwacha, Caroline S Zhu, Shannon Scroggins, Ronald M. Stewart, Mark DeRosa, Donald H. Jenkins, Rachelle B. Jonas, Susannah E. Nicholson, Elizabeth Scherer, Zhao Lai
Publikováno v:
J Trauma Acute Care Surg
BACKGROUND Traumatic injury can lead to a compromised intestinal epithelial barrier, decreased gut perfusion, and inflammation. While recent studies indicate that the gut microbiome (GM) is altered early following traumatic injury, the impact of GM c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab704cd5edd2d1296f8da86ec459fb2
https://doi.org/10.1097/ta.0000000000002612
https://doi.org/10.1097/ta.0000000000002612
Autor:
Susannah E. Nicholson, Michael O'Boyle, David M. Burmeister, Lora Talley Watts, Martin G. Schwacha, Zhao Lai, Matthew K. McIntyre, Shannon Scroggins
Publikováno v:
Neurosurgery. 66:310-683
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23e77785a91ac7614dca51dfb01d0623
https://doi.org/10.1093/neuros/nyz310_683
https://doi.org/10.1093/neuros/nyz310_683
Autor:
Susannah E. Nicholson, Robbie K. Montgomery, Martin G. Schwacha, Andrew P. Cap, Shannon Scroggins
Publikováno v:
Cellular Immunology. 338:21-26
Myeloid-derived suppressor cells (MDSCs) have been identified in the burn wound, however their characterization is incomplete. To study this, mice were subjected to a major burn and skin cells were isolated 3 days thereafter for analysis. Significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263d2d575826d94068c33268cf92cabd
https://doi.org/10.1016/j.cellimm.2019.03.001
https://doi.org/10.1016/j.cellimm.2019.03.001
Autor:
Yi Zou, David M. Burmeister, Martin G. Schwacha, Caroline S Zhu, Brian J. Eastridge, Aaron M. Lewis, Daniel Merrill, Larry M. Newton, Susannah E. Nicholson, Daniel N. Darlington, Zhao Lai, Shannon Scroggins
Publikováno v:
The American Journal of Surgery. 216:699-705
Background This study characterizes the gastrointestinal (GI) microbiome in a pre-clinical polytrauma hemorrhage model. Methods Rats (n = 6) were anesthetized, hemorrhaged 20% of their blood volume, and subjected to a femur fracture and crush injurie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91efbc65dfc4be39eec8ecd0c1dcedda
https://doi.org/10.1016/j.amjsurg.2018.07.026
https://doi.org/10.1016/j.amjsurg.2018.07.026
Autor:
Mark DeRosa, Daniel L. Dent, Victor A. Convertino, David A. Wampler, Abdul Q. Alarhayem, Lilian Liao, Susannah E. Nicholson, Michael C. Johnson, Ramon F. Cestero, Martin G. Schwacha, Brian J. Eastridge, Mark T. Muir, Kevin K. Chung, John G. Myers, Robert Carter, Ronald M. Stewart
Publikováno v:
Shock. 49:295-300
Hemorrhage is one of the most substantial causes of death after traumatic injury. Standard measures, including systolic blood pressure (SBP), are poor surrogate indicators of physiologic compromise until compensatory mechanisms have been overwhelmed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d795a11dadc8ab9e3c734418793f9e
https://doi.org/10.1097/shk.0000000000000959
https://doi.org/10.1097/shk.0000000000000959
Autor:
Andrew P. Cap, Beverley S. Schaffer, Heather F. Pidcoke, Rachel Morris, Daniel N. Darlington, Kevin K. Chung, Jonathan B. Lundy, Martin G. Schwacha
Publikováno v:
Blood Coagulation & Fibrinolysis. 29:48-54
Alterations in coagulation, inflammation and immunity are associated with major injury. As platelets have both coagulation and immune functions, the aim of this study is to correlate platelet activation with the immunoinflammatory response in trauma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83530a37dec9eedb290b6e21ed48233
https://doi.org/10.1097/mbc.0000000000000665
https://doi.org/10.1097/mbc.0000000000000665