Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro

Autor: David C. Emery, David I. Marks, Aimie Norton, Claire M Rice, Martin G Guttridge, Neil J Scolding, Pamela Sarkar, Alastair Wilkins, Paul Virgo, Juliana Redondo, Joya Pawade, Kevin C Kemp

Publikováno v: Redondo, J, Sarkar, P, Kemp, K, Virgo, P F, Pawade, J, Norton, A, Emery, D C, Guttridge, M G, Marks, D I, Wilkins, A, Scolding, N J & Rice, C M 2018, ' Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro ', Multiple Sclerosis Journal, vol. 24, no. 7, pp. 919-931 . https://doi.org/10.1177/1352458517711276
Multiple Sclerosis (Houndmills, Basingstoke, England)

Background: Autologous bone-marrow-derived cells are currently employed in clinical studies of cell-based therapy in multiple sclerosis (MS) although the bone marrow microenvironment and marrow-derived cells isolated from patients with MS have not be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12479caf14cb0c11ebebe21d80a3925e
https://doi.org/10.1177/1352458517711276

An internal positive control for the enumeration of CD45+ and CD34+ cells by flow cytometry allows monitoring of reagent and operator performance

Autor: Martin G Guttridge, D. Hollyman, H. Belfield, A. Lankester, Suzanne M. Watt

Publikováno v: Cytotherapy. 9:275-282

Background Three-color flow cytometry assays are used to determine CD34 cell doses prior to stem cell transplantation. These assays require highquality reagents that are dispensed accurately to ensure reproducible results. We have developed a flow cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc70e7919c9289af8bf49374161ed98
https://doi.org/10.1080/14653240701247846

A journey from basic stem cell discovery to clinical application: the case of adventitial progenitor cells

Autor: Gianni D Angelini, Tom Morgan, Helen L Spencer, Lucy Culliford, Martin G Guttridge, Costanza Emanueli, Paolo Madeddu, Jonathan Rowlinson, Sadie C. Slater

Publikováno v: Regenerative medicine. 10(1)

Ischemia is a leading cause of death in the western world. Regenerative medicine aims to improve healing of ischemic injury by complementing pharmacologic/interventional treatments. Navigating regenerative therapies from ‘bench-to-bedside’ is a m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a13e6ffa085050d8e1c7abc673b08a
https://pubmed.ncbi.nlm.nih.gov/25562351

HLA-B15: A widespread and diverse family of HLA-B alleles

Autor: William H. Hildebrand, Martin G. Guttridge, Michael Bunce, Paul I. Terasaki, Wilma B. Bias, Susan Y. Shen, John D. Domena, M. Lau, Peter Parham, Steven G.E. Marsh

Publikováno v: Tissue Antigens. 43:209-218

HLA-B15 embraces a multiplicity of antigenic specificities which vary in their distribution amongst human populations. To correlate B15 molecular structure with the serological picture we have sequenced alleles encoding the various subspecificities o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b99a81a745bf39c1d288ed66ce57aa
https://doi.org/10.1111/j.1399-0039.1994.tb02327.x

Early lymphocyte recovery is an important determinant of outcome following allogeneic transplantation with CD34+ selected graft and limited T-cell addback

Autor: Martin G Guttridge, Derwood Pamphilon, Alan Lankester, J Brown, David I. Marks, Suparno Chakrabarti

Publikováno v: Bone marrow transplantation. 32(1)

We evaluated the outcome of 29 patients (age 22-60 years), who received a CD34+selected related (n=16) or unrelated graft (n=13) with limited T-cell addback (TCAB) (median 5.9 x 10(4)/kg) following full-intensity conditioning for haematological malig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee574b9b021e3ac53bd1e6319c51fb3a
https://pubmed.ncbi.nlm.nih.gov/12815474