Interleukin-6 receptor antibodies (tocilizumab) in acute myocardial infarction with intermediate to high risk of cardiogenic shock development (DOBERMANN-T): study protocol for a double-blinded, placebo-controlled, single-center, randomized clinical trial

Autor: Joakim Bo Kunkel, Sarah Louise Duus Holle, Christian Hassager, Redi Pecini, Sebastian Wiberg, Pernille Palm, Lene Holmvang, Lia Evi Bang, Jesper Kjærgaard, Jakob Hartvig Thomsen, Thomas Engstrøm, Jacob Eifer Møller, Jacob Thomsen Lønborg, Martin Frydland, Helle Søholm

Publikováno v: Trials, Vol 25, Iss 1, Pp 1-12 (2024)

Abstract Background Inflammation and neurohormonal activation play a significant role in the adverse outcome seen in acute myocardial infarction (AMI) and the development of cardiogenic shock (CS), which is associated with a mortality rate up to 50%.

Externí odkaz: https://doaj.org/article/cc0311fa571748c7ae1243f0f04615cf

Association of apolipoprotein M and sphingosine-1-phosphate with brown adipose tissue after cold exposure in humans

Autor: Anna Borup, Ida Donkin, Mariëtte R. Boon, Martin Frydland, Borja Martinez-Tellez, Annika Loft, Sune H. Keller, Andreas Kjaer, Jesper Kjaergaard, Christian Hassager, Romain Barrès, Patrick C. N. Rensen, Christina Christoffersen

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract The HDL-associated apolipoprotein M (apoM) and its ligand sphingosine-1-phosphate (S1P) may control energy metabolism. ApoM deficiency in mice is associated with increased vascular permeability, brown adipose tissue (BAT) mass and activity,

Externí odkaz: https://doaj.org/article/ac928242ef3141f18c4d97ecb075955f

Data on association between QRS duration on prehospital ECG and mortality in patients with confirmed STEMI

Autor: Rikke Hansen, Martin Frydland, Ole Kristian Møller-Helgestad, Matias Greve Lindholm, Lisette Okkels Jensen, Lene Holmvang, Hanne Berg Ravn, Jesper Kjærgaard, Christian Hassager, Jacob Eifer Møller

Publikováno v: Data in Brief, Vol 15, Iss , Pp 12-17 (2017)

Data presented in this article relates to the research article entitled âAssociation between QRS duration on prehospital ECG and mortality in patients with suspected STEMIâ (Hansen et al., in press) [1].Data on the prognostic effect of automaticall

Externí odkaz: https://doaj.org/article/3c1abd6fe5354caf8b87fda3ad40b386

MR‐proADM as a Prognostic Marker in Patients With ST‐Segment–Elevation Myocardial Infarction—DANAMI‐3 (a Danish Study of Optimal Acute Treatment of Patients With STEMI) Substudy

Autor: Alexander C. Falkentoft, Rasmus Rørth, Kasper Iversen, Dan E. Høfsten, Henning Kelbæk, Lene Holmvang, Martin Frydland, Mikkel M. Schoos, Steffen Helqvist, Anna Axelsson, Peter Clemmensen, Erik Jørgensen, Kari Saunamäki, Hans‐Henrik Tilsted, Frants Pedersen, Christian Torp‐Pedersen, Klaus F. Kofoed, Jens P. Goetze, Thomas Engstrøm, Lars Køber

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 11 (2018)

BackgroundMidregional proadrenomedullin (MR‐proADM) has demonstrated prognostic potential after myocardial infarction (MI). Yet, the prognostic value of MR‐proADM at admission has not been examined in patients with ST‐segment–elevation MI (ST

Externí odkaz: https://doaj.org/article/cf5148fd7f27491a82a484b9582dc30a

Oxygen Targets in Comatose Survivors of Cardiac Arrest

Autor: Henrik Schmidt, Jesper Kjaergaard, Christian Hassager, Simon Mølstrøm, Johannes Grand, Britt Borregaard, Laust E. Roelsgaard Obling, Søren Venø, Laura Sarkisian, Dmitry Mamaev, Lisette O. Jensen, Benjamin Nyholm, Dan E. Høfsten, Jakob Josiassen, Jakob H. Thomsen, Jens J. Thune, Matias G. Lindholm, Martin A. Stengaard Meyer, Matilde Winther-Jensen, Marc Sørensen, Martin Frydland, Rasmus P. Beske, Ruth Frikke-Schmidt, Sebastian Wiberg, Søren Boesgaard, Vibeke Lind Jørgensen, Jacob E. Møller

Publikováno v: Schmidt, H, Kjaergaard, J, Hassager, C, Mølstrøm, S, Grand, J, Borregaard, B, Obling, L E R, Venø, S, Sarkisian, L, Mamaev, D, Jensen, L O, Nyholm, B, Høfsten, D E, Josiassen, J, Thomsen, J H, Thune, J J, Lindholm, M G, Meyer, M A S, Winther-Jensen, M, Sørensen, M, Frydland, M, Beske, R P, Frikke-Schmidt, R, Wiberg, S, Boesgaard, S, Jørgensen, V L & Møller, J E 2022, ' Oxygen Targets in Comatose Survivors of Cardiac Arrest ', New England Journal of Medicine, vol. 387, no. 16, pp. 1467-1476 . https://doi.org/10.1056/NEJMoa2208686

BACKGROUND The appropriate oxygenation target for mechanical ventilation in comatose survivors of out-of-hospital cardiac arrest is unknown. METHODS In this randomized trial with a 2-by-2 factorial design, we randomly assigned comatose adults with ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29a1a67d378828785f5394d52e4530f
https://doi.org/10.1056/nejmoa2208686