Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Martin Forbak"'
Autor:
Amit K. Dutta, Eira Choudhary, Xuan Wang, Monika Záhorszka, Martin Forbak, Philipp Lohner, Henning J. Jessen, Nisheeth Agarwal, Jana Korduláková, Claudia Jessen-Trefzer
Publikováno v:
ACS Central Science, Vol 5, Iss 4, Pp 644-650 (2019)
Externí odkaz:
https://doaj.org/article/9874e78214ad40049b4868a9d90a921b
Autor:
Ghada Bouz, Petr Šlechta, Ondřej Jand’ourek, Klára Konečná, Pavla Paterová, Pavel Bárta, Martin Novák, Radim Kučera, Nils-Jørgen Knudsen Dal, Federico Fenaroli, Júlia Zemanová, Martin Forbak, Jana Korduláková, Oto Pavliš, Pavla Kubíčková, Martin Doležal, Jan Zitko
Publikováno v:
ACS infectious diseases.
Apart from the SARS-CoV-2 virus, tuberculosis remains the leading cause of death from a single infectious agent according to the World Health Organization. As part of our long-term research, we prepared a series of hybrid compounds combining pyrazina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f45d64c58a61c965726926767b4911
https://pubmed.ncbi.nlm.nih.gov/36577009
https://pubmed.ncbi.nlm.nih.gov/36577009
Autor:
Monika Záhorszká, Xuan Wang, Philipp Lohner, Amit K. Dutta, Jana Korduláková, Eira Choudhary, Martin Forbak, Henning J. Jessen, Claudia Jessen-Trefzer, Nisheeth Agarwal
Publikováno v:
ACS Central Science, Vol 5, Iss 4, Pp 644-650 (2019)
[Image: see text] Trehalose is a natural glucose-derived disaccharide found in the cell wall of mycobacteria. It enters the mycobacterial cell through a highly specific trehalose transporter system. Subsequently, trehalose is equipped with mycolic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a565bbcf8a3c43576903347aed3dc13d
https://doi.org/10.1021/acscentsci.8b00962
https://doi.org/10.1021/acscentsci.8b00962
Autor:
Antonio Peixoto, Monika Záhorszká, Jana Korduláková, Mathieu Danel, Fernanda Goncalves, Elodie Vega, Asma Farjallah, Maria Rosalia Pasca, Mary Jackson, Giulia Degiacomi, Laurent R. Chiarelli, Cendrine Seguin, Martin Forbak, Christian Lherbet, Stefan Chassaing, Chantal Carayon, Souhir Abid, Marco Fumagalli, Anna E. Grzegorzewicz
Publikováno v:
ACS Infectious Diseases
ACS Infectious Diseases, American Chemical Society, 2021, 7 (3), pp.552-565. ⟨10.1021/acsinfecdis.0c00325⟩
ACS Infectious Diseases, 2021, 7 (3), pp.552-565. ⟨10.1021/acsinfecdis.0c00325⟩
ACS Infectious Diseases, American Chemical Society, 2021, 7 (3), pp.552-565. ⟨10.1021/acsinfecdis.0c00325⟩
ACS Infectious Diseases, 2021, 7 (3), pp.552-565. ⟨10.1021/acsinfecdis.0c00325⟩
International audience; A novel coumarin-based molecule, designed as a fluorescent surrogate of a thiacetazone-derived antitubercular agent, was quickly and easily synthesized from readily available starting materials. This small molecule, coined Cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5b5cd98cba63d79872ca55f29014c7
https://hal.archives-ouvertes.fr/hal-03209886/document
https://hal.archives-ouvertes.fr/hal-03209886/document
Autor:
Asma, Farjallah, Laurent R, Chiarelli, Martin, Forbak, Giulia, Degiacomi, Mathieu, Danel, Fernanda, Goncalves, Chantal, Carayon, Cendrine, Seguin, Marco, Fumagalli, Monika, Záhorszká, Elodie, Vega, Souhir, Abid, Anna, Grzegorzewicz, Mary, Jackson, Antonio, Peixoto, Jana, Korduláková, Maria Rosalia, Pasca, Christian, Lherbet, Stefan, Chassaing
Publikováno v:
ACS Infect Dis
A novel coumarin-based molecule, designed as a fluorescent surrogate of a thiacetazone-derived antitubercular agent, was quickly and easily synthesized from readily available starting materials. This small molecule, coined as Coum-TAC, exhibited a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d98272b7bcc4d72b13b9989d7e89ee69
https://pubmed.ncbi.nlm.nih.gov/33617235
https://pubmed.ncbi.nlm.nih.gov/33617235
Autor:
Josè Camilla Sammartino, Giorgia Mori, Martin Forbak, Maria Rosalia Pasca, Olga Riabova, Laurent R. Chiarelli, Giulia Degiacomi, Artem Grigorov, Alexander Lepioshkin, Katarína Mikušová, Giovanna Riccardi, Beatrice Silvia Orena, Tatyana L. Azhikina, Fabio Gosetti, Vadim Makarov, Marcello Manfredi, Jana Korduláková, Emilio Marengo, Arianna Buzzi, Elena G. Salina, Jan Madacki
The thienopyrimidine TP053 is an antitubercular prodrug active against both replicating and nonreplicating Mycobacterium tuberculosis (M. tuberculosis) cells, which requires activation by the mycothiol-dependent nitroreductase Mrx2. The investigation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1088bb5004f60e105b1d837e21de70
http://hdl.handle.net/10281/253275
http://hdl.handle.net/10281/253275
Autor:
Clara Franch, Rosangela Frita, Joel S. Freundlich, Alexandre Vandeputte, Maria Rosalia Pasca, Courtney Veilleux, Mohamad Sabbah, Rajiv Kumar Jha, Beatrice Silvia Orena, Eik Hoffmann, Katarína Mikušová, Liliana Rodrigues, Adwait Anand Godbole, Lesley A. Mitchenall, Pradeep Kumar, Valakunja Nagaraja, Nathalie Deboosere, Stanislav Huszár, Priscille Brodin, Clara Aguilar-Pérez, José A. Aínsa, Sean Ekins, Riccardo Russo, Nancy D. Connell, Anthony Maxwell, Júlia Zemanová, Martin Forbak, Thomas J. Lane, Giorgia Mori
Publikováno v:
Tuberculosis. 112:98-109
The search for compounds with biological activity for many diseases is turning increasingly to drug repurposing. In this study, we have focused on the European Union-approved antimalarial pyronaridine which was found to have in vitro activity against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1ba750c5c3cc0488b8f132f5da37c7
https://doi.org/10.1016/j.tube.2018.08.004
https://doi.org/10.1016/j.tube.2018.08.004
Autor:
János Pató, Jan Rybniker, Gaëlle S. Kolly, Rita Székely, Neeraj Dhar, Zuzana Palčeková, Anthony Vocat, Digby F. Warner, Júlia Zemanová, Monica G Rengifo, Priscille Brodin, John D. McKinney, Adrian Suarez Covarrubias, Vinayak Singh, François Signorino-Gelo, Joseph Buechler, Sherry L. Mowbray, Ruben C. Hartkoorn, José A. Aínsa, Stewart T. Cole, Vincent Delorme, Martin Forbak, Isabella Santi, Joanna C. Evans, Liliana Rodrigues, György Kéri, Katarína Mikušová, Kai Johnsson, Jana Korduláková, Graham Knott, Valerie Mizrahi
Publikováno v:
Molecular Microbiology. 103:13-25
There is an urgent need to discover new anti-tubercular agents with novel mechanisms of action in order to tackle the scourge of drug-resistant tuberculosis. Here, we report the identification of such a molecule - an AminoPYrimidine-Sulfonamide (APYS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c108991780420cb8426b100589be6471
https://doi.org/10.1111/mmi.13535
https://doi.org/10.1111/mmi.13535
Autor:
Katarína Mikušová, Fabio Gosetti, Vadim Makarov, Giovanna Riccardi, Elena A. Salina, Giorgio Mori, Alexander Lepioshkin, Jan Madacki, Emilio Marengo, Martin Forbak, Jana Korduláková, Arianna Buzzi, Beatrice Silvia Orena, Olga Riabova, Tatyana L. Azhikina, Laurent R. Chiarelli, Artyom Grigorov, Maria Rosalia Pasca, Marcello Manfredi, Giulia Degiacomi
Publikováno v:
SSRN Electronic Journal.
The thienopyrimidine TP053 is an antitubercular prodrug active against both replicating and non-replicating Mycobacterium tuberculosis cells. Its mechanism of activation involves the reduction of a NO2 group by the mycothiol-dependent reductase Mrx2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa4413258c3f7cfdc0f67778f902fb5d
https://doi.org/10.2139/ssrn.3279413
https://doi.org/10.2139/ssrn.3279413