Functional significance of the signal transduction pathways Akt and Erk in ovarian follicles: in vitro and in vivo studies in cattle and sheep

Autor: Ryan Kate E, Glister Claire, Lonergan Pat, Martin Finian, Knight Phil G, Evans Alexander CO

Publikováno v: Journal of Ovarian Research, Vol 1, Iss 1, p 2 (2008)

Abstract Background The intracellular signalling mechanisms that regulate ovarian follicle development are unclear; however, we have recently shown differences in the Akt and Erk signalling pathways in dominant compared to subordinate follicles. The

Externí odkaz: https://doaj.org/article/8f4a69de181049b0b4c583db27c72c0e

Diabetic kidney disease and immune modulation

Autor: Hickey, Fionnuala B, Martin, Finian

Publikováno v: In Current Opinion in Pharmacology August 2013 13(4):602-612

Gremlin1 plays a key role in kidney development and renal fibrosis

Autor: Church, Rachel H., Ali, Imran, Tate, Mitchel, Lavin, Deborah, Krishnakumar, Arjun, Kok, Helena M., Hombrebueno, Jose R., Dunne, Philip D., Bingham, Victoria, Goldschmeding, Roel, Martin, Finian, Brazil, Derek P.

Publikováno v: American Journal of Physiology-Renal Physiology, 312(6), F1141. American Physiological Society
Church, R H, Ali, I, Tate, M, Lavin, D, Krishnakumar, A, Kok, H M, Romero, J, Dunne, P, Bingham, V, Goldschmeding, R, Martin, F & Brazil, D 2017, ' Gremlin1 plays a key role in kidney development and renal fibrosis ', American journal of physiology. Renal physiology . https://doi.org/10.1152/ajprenal.00344.2016

Gremlin1 (Grem1), an antagonist of bone morphogenetic proteins, plays a key role in embryogenesis. A highly specific temporospatial gradient of Grem1 and bone morphogenetic protein signaling is critical to normal lung, kidney, and limb development. G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::32bc5e9e6ecc6b48169ca08f8067ff89
https://dspace.library.uu.nl/handle/1874/360355

Association Testing of Previously Reported Variants in a Large Case-Control Meta-analysis of Diabetic Nephropathy

Autor: Williams, Winfred W., Salem, Rany M., McKnight, Amy Jayne, Sandholm, Niina, Forsblom, Carol, Taylor, Andrew, Guiducci, Candace, McAteer, Jarred B., McKay, Gareth J., Isakova, Tamara, Brennan, Eoin P., Sadlier, Denise M., Palmer, Cameron, Söderlund, Jenny, Fagerholm, Emma, Harjutsalo, Valma, Lithovius, Raija, Gordin, Daniel, Hietala, Kustaa, Kytö, Janne, Parkkonen, Maija, Rosengård-Bärlund, Milla, Thorn, Lena, Syreeni, Anna, Tolonen, Nina, Saraheimo, Markku, Wadén, Johan, Pitkäniemi, Janne, Sarti, Cinzia, Tuomilehto, Jaakko, Tryggvason, Karl, Österholm, Anne-May, He, Bing, Bain, Steve, Martin, Finian, Godson, Catherine, Hirschhorn, Joel N., Maxwell, Alexander P., Groop, Per-Henrik, Florez, Jose C.

Publikováno v: Diabetes

We formed the GEnetics of Nephropathy–an International Effort (GENIE) consortium to examine previously reported genetic associations with diabetic nephropathy (DN) in type 1 diabetes. GENIE consists of 6,366 similarly ascertained participants of Eu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47df1a2b939ee5ad2b1b6532d1a90532
http://europepmc.org/articles/PMC3402313

Genetic studies of body mass index yield new insights for obesity biology

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G, Kretzler, Matthias, Fraser, Ross M, Colhoun, Helen M, Panduru, Nicolae Mircea, Gu, Harvest F, Brismar, Kerstin, Zerbini, Gianpaolo, Hadjadj, Samy, Marre, Michel, Groop, Leif, Lajer, Maria, Bull, Shelley B, Garcia, Melissa E, Waggott, Daryl, Paterson, Andrew D, Savage, David A, Bain, Stephen C, Martin, Finian, Hirschhorn, Joel N, Godson, Catherine, Florez, Jose C, Groop, Per-Henrik, Maxwell, Alexander P, Geller, Frank, Willer, Cristen J, Schmidt, Ellen M, Sengupta, Sebanti, Peloso, Gina M, Gustafsson, Stefan, Kanoni, Stavroula, Ganna, Andrea, Chen, Jin, Buchkovich, Martin L, Mora, Samia, Giedraitis, Vilmantas, Beckmann, Jacques S, Bragg-Gresham, Jennifer L, Chang, Hsing-Y, Demirkan, Ayşe, Den Hertog, Heleen M, Do, Ron, Donnelly, Louise A, Ehret, Georg B, Esko, Tõnu, Feitosa, Mary F, Gigante, Bruna, Ferreira, Teresa, Fischer, Krista, Fontanillas, Pierre, Freitag, Daniel F, Gurdasani, Deepti, Heikkilä, Kauko, Hyppönen, Elina, Isaacs, Aaron, Jackson, Anne U, Esko, Tonu, Go, Alan S, 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Nature, 518(7538), 197. Nature Publishing Group
Nature
Nature, 518(7538), 197-U401
Nature, Vol. 518, No 7538 (2015) pp. 197-206
Nature, vol. 518, no. 7538, pp. 197-206
Nature 518(7538), 197-206 (2015). doi:10.1038/nature14177
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Locke, A E, Kahali, B, Berndt, S I, Justice, A E, Pers, T H, Day, F R, Powell, C, Vedantam, S, Buchkovich, M L, Yang, J, Croteau-Chonka, D C, Esko, T, Fall, T, Ferreira, T, Gustafsson, S, Kutalik, Z, Luan, J, Maegi, R, Randall, J C, Winkler, T W, Wood, A R, Workalemahu, T, Faul, J D, Smith, J A, Zhao, J H, Zhao, W, Chen, J, Fehrmann, R, Hedman, A K, Karjalainen, J, Schmidt, E M, Absher, D, Amin, N, Anderson, D, Beekman, M & Bolton, J L & Bragg-Gresham, L & Buyske, S & Demirkan, A & Deng, G & Fraser, R M & Hayward, C & McLachlan, S & Campbell, H & Morris, A D & Price, J F & Rudan, I & Walker, M & Wilson, J F & Visscher, P M 2015, ' Genetic studies of body mass index yield new insights for obesity biology ', Nature, vol. 518, no. 7538, pp. 197-U401 . https://doi.org/10.1038/nature14177
Nature, 518(7538), 197-U401. Nature Publishing Group
Nature, 518, 7538, pp. 197-206
Nature, 518, 197-206

Item does not contain fulltext Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure

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