Zobrazeno 1 - 10
of 332
pro vyhledávání: '"Martin Feelisch"'
Autor:
Ahilanandan Dushianthan, Paul Mouncey, Daniel Martin, Lamprini Lampro, Tasnin Shahid, Victoria Goss, Amelia Francis Johnson, William Herbert, Angelica Cazley, Mark Lamond, William Jones, Karen Salmon, Florence Neyroud, Magdalena Minnion, Julian Lentaigne, Grielof Koster, Madhuri Panchal, Anthony D Postle, Helen Moyses, Michael P W Grocott, Martin Feelisch
Publikováno v:
NIHR Open Research, Vol 4 (2024)
Background MecROX is a mechanistic sub-study of the UK-ROX trial which was designed to evaluate the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care. This is based on the
Externí odkaz:
https://doaj.org/article/2d78ef0bea914040a6d45e0af39db2f2
Autor:
Joseph Larvin, Mark Edwards, Daniel S. Martin, Martin Feelisch, Michael P.W. Grocott, Andrew F. Cumpstey
Publikováno v:
BJA Open, Vol 10, Iss , Pp 100277- (2024)
Summary: Oxygen is the most used drug in anaesthesia. Despite such widespread use, optimal perioperative oxygen administration remains highly controversial because of concerns about the competing harms of both hyperoxia and hypoxia.Notwithstanding a
Externí odkaz:
https://doaj.org/article/dfa85bef96c140319ae2a86a3320826b
Autor:
Ahilanandan Dushianthan, Howard W. Clark, David Brealey, Danny Pratt, James B. Fink, Jens Madsen, Helen Moyses, Lewis Matthews, Tracy Hussell, Ratko Djukanovic, Martin Feelisch, Anthony D. Postle, Michael P. W. Grocott
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract SARS-CoV-2 directly targets alveolar epithelial cells and can lead to surfactant deficiency. Early reports suggested surfactant replacement may be effective in improving outcomes. The aim of the study to assess the feasibility and efficacy o
Externí odkaz:
https://doaj.org/article/a77d36c23f7d4e1287d0bc5878c169f2
Autor:
Yang Luo, Laurent Chatre, Shaden Melhem, Zayana M. Al-Dahmani, Natalie Z.M. Homer, Anneke Miedema, Leo E. Deelman, Matthew R. Groves, Martin Feelisch, Nicholas M. Morton, Amalia Dolga, Harry van Goor
Publikováno v:
Redox Biology, Vol 68, Iss , Pp 102965- (2023)
Thiosulfate sulfurtransferase (TST, EC 2.8.1.1) was discovered as an enzyme that detoxifies cyanide by conversion to thiocyanate (rhodanide) using thiosulfate as substrate; this rhodanese activity was subsequently identified to be almost exclusively
Externí odkaz:
https://doaj.org/article/60a049bd7a644081bdd281cc51e743d3
Autor:
Jia L. Stevens, Helen T. McKenna, Helder Filipe, Laurie Lau, Bernadette O. Fernandez, Andrew J. Murray, Martin Feelisch, Daniel S. Martin
Publikováno v:
Perioperative Medicine, Vol 12, Iss 1, Pp 1-11 (2023)
Abstract Background Tissue injury induces inflammation and the surgical stress response, which are thought to be central to the orchestration of recovery or deterioration after surgery. Enhanced formation of reactive oxygen and nitrogen species accom
Externí odkaz:
https://doaj.org/article/419775ee06ed4fb197582603ec361a9e
Publikováno v:
Open Biology, Vol 13, Iss 9 (2023)
Diurnal and seasonal rhythmicity, entrained by environmental and nutritional cues, is a vital part of all life on Earth operating at every level of organization; from individual cells, to multicellular organisms, whole ecosystems and societies. Redox
Externí odkaz:
https://doaj.org/article/462388b321ae4a8aa5f9ff24c9dbffd1
Autor:
Kayleigh Griffiths, Tomoaki Ida, Masanobu Morita, Reece J. Lamb, Jordan J. Lee, Michael P. Frenneaux, Jon M. Fukuto, Takaaki Akaike, Martin Feelisch, Melanie Madhani
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102605- (2023)
Earlier studies revealed the presence of cysteine persulfide (CysSSH) and related polysulfide species in various mammalian tissues. CysSSH has both antioxidant and oxidant properties, modulates redox-dependent signal transduction and has been shown t
Externí odkaz:
https://doaj.org/article/553db8cbeb424851b58504314357e5b8
Autor:
Arno R. Bourgonje, Damian Kloska, Anna Grochot-Przęczek, Martin Feelisch, Antonio Cuadrado, Harry van Goor
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102603- (2023)
Inflammatory bowel diseases (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), are intimately associated with inflammation and overproduction of reactive oxygen species (ROS). Temporal and inter-individual variabilities in disease
Externí odkaz:
https://doaj.org/article/0fbaa4e93d704d2bac68dbd106eeab49
Autor:
Tim J. M. Wallis, Magdalena Minnion, Anna Freeman, Andrew Bates, James M. Otto, Stephen A. Wootton, Sophie V. Fletcher, Michael P. W. Grocott, Martin Feelisch, Mark G. Jones, Sandy Jack
Publikováno v:
Antioxidants, Vol 12, Iss 8, p 1645 (2023)
Exercise training is recommended for patients with idiopathic pulmonary fibrosis (IPF); however, the mechanism(s) underlying its physiological benefits remain unclear. We investigated the effects of an individualised aerobic interval training program
Externí odkaz:
https://doaj.org/article/6b618fa1066149759942b5ce2127fa80
Autor:
Martin Feelisch, Miriam M. Cortese-Krott, Jérôme Santolini, Stephen A. Wootton, Alan A. Jackson
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 21, Pp 623-646 (2022)
Living organisms need to be able to cope with environmental challenges and other stressors and mount adequate responses that are as varied as the spectrum of those challenges. Understanding how the multi-layered biological stress responses become int
Externí odkaz:
https://doaj.org/article/6ac8a5075a244c80824f2f5a73631937