Zobrazeno 1 - 10
of 445
pro vyhledávání: '"Martin F. Lavin"'
Autor:
Hannah C. Leeson, Julio Aguado, Cecilia Gómez-Inclán, Harman Kaur Chaggar, Atefah Taherian Fard, Zoe Hunter, Martin F. Lavin, Alan Mackay-Sim, Ernst J. Wolvetang
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106562- (2024)
Ataxia Telangiectasia (AT) is a rare disorder caused by mutations in the ATM gene and results in progressive neurodegeneration for reasons that remain poorly understood. In addition to its central role in nuclear DNA repair, ATM operates outside the
Externí odkaz:
https://doaj.org/article/b826d148b82f43529a6250e191ea9f40
Autor:
Kong-Nan Zhao, Goce Dimeski, Paul Masci, Lambro Johnson, Jingjing Wang, John de Jersey, Michael Grant, Martin F. Lavin
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 645 (2024)
We recently reported the potential application of recombinant prothrombin activator ecarin (RAPClot™) in blood diagnostics. In a new study, we describe RAPClot™ as an additive to develop a novel blood collection prototype tube that produces the h
Externí odkaz:
https://doaj.org/article/9b6c2675e9614e7f9d9529d65fc869b7
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/ae12d87ba349433aa8c4a9a27b37a7bc
Autor:
Hannah C. Leeson, Zoe Hunter, Harman Kaur Chaggar, Martin F. Lavin, Alan Mackay-Sim, Ernst J. Wolvetang
Publikováno v:
Stem Cell Research, Vol 56, Iss , Pp 102528- (2021)
Ataxia Telangiectasia is a rare autosomal recessive disorder caused by a mutated ATM gene. The most debilitating symptom of Ataxia Telangiectasia is the progressive neurodegeneration of the cerebellum, though the molecular mechanisms driving this deg
Externí odkaz:
https://doaj.org/article/6699cf1e6cf540f2a7dc0930af1fb9f5
Autor:
Kong-Nan Zhao, Paul Masci, Goce Dimeski, Lambro Johnson, Michael Grant, John de Jersey, Martin F. Lavin
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1704 (2022)
We describe here the purification and cloning of a codon-optimized form of the snake prothrombin activator ecarin from the saw scaled viper (Echis carinatus) expressed in mammalian cells. Expression of recombinant ecarin (rEcarin) was carried out in
Externí odkaz:
https://doaj.org/article/d07537b028744558996b43448a0c1804
Autor:
Shu-xian Li, Chao Li, Xin-ru Pang, Juan Zhang, Gong-chang Yu, Abrey J. Yeo, Martin F. Lavin, Hua Shao, Qiang Jia, Cheng Peng
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Long-term exposure to crystalline silica particles leads to silicosis characterized by persistent inflammation and progressive fibrosis in the lung. So far, there is no specific treatment to cure the disease other than supportive care. In this study,
Externí odkaz:
https://doaj.org/article/5d159afa657940dc889d9bc6bf212b24
Autor:
Abrey J. Yeo, Kok L. Chong, Magtouf Gatei, Dongxiu Zou, Romal Stewart, Sarah Withey, Ernst Wolvetang, Robert G. Parton, Adam D. Brown, Michael B. Kastan, David Coman, Martin F. Lavin
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101972- (2021)
Summary: There is evidence that ATM mutated in ataxia-telangiectasia (A-T) plays a key role in protecting against mitochondrial dysfunction, the mechanism for which remains unresolved. We demonstrate here that ATM-deficient cells are exquisitely sens
Externí odkaz:
https://doaj.org/article/395a2dfe24654d80a406b2e92e5fabf0
Autor:
Enguo Zhang, Ye Yang, Shangya Chen, Cheng Peng, Martin F. Lavin, Abrey J. Yeo, Chao Li, Xiaoshan Liu, Yingjun Guan, Xinjing Du, Zhongjun Du, Hua Shao
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-14 (2018)
Abstract Background Pulmonary fibrosis induced by silica dust is an irreversible, chronic, and fibroproliferative lung disease with no effective treatment at present. Previous studies have shown that early intervention with bone marrow mesenchymal st
Externí odkaz:
https://doaj.org/article/fa652d108cc94e139cb5df1c24043ecd
Autor:
Shangya Chen, Guanqun Cui, Cheng Peng, Martin F. Lavin, Xiaoying Sun, Enguo Zhang, Ye Yang, Yingjun Guan, Zhongjun Du, Hua Shao
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-12 (2018)
Abstract Background Silicosis has been topping the list of high-incidence occupational diseases in developing countries and cannot be completely cured. Recent advances in stem cell research have made possible the treatment of various diseases includi
Externí odkaz:
https://doaj.org/article/e83fc0c1f11a478491eb5d55fa484b0e
Autor:
Matthew J. Roberts, Renee S. Richards, Clement W.K. Chow, Marion Buck, John Yaxley, Martin F. Lavin, Horst Joachim Schirra, Robert A. Gardiner
Publikováno v:
Prostate International, Vol 5, Iss 4, Pp 149-157 (2017)
Background: Diagnosis and monitoring of localized prostate cancer requires discovery and validation of noninvasive biomarkers. Nuclear magnetic resonance (NMR)-based metabolomics of seminal plasma reportedly improves diagnostic accuracy, but requires
Externí odkaz:
https://doaj.org/article/5476f440b7dc4b5d8b5fcfdc73b7d73b