Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Martin F. Jones"'
Autor:
Jean-Marc Henry, David Milne, Dave Perkins, William Hicks, David R. J. Hose, Andrew D. Campbell, Alexander K. Mullen, Phillip A. Inglesby, Steven A. Raw, Martin F. Jones
Publikováno v:
Organic Process Research & Development. 27:488-495
Autor:
Adam D. Clayton, Edward O. Pyzer‐Knapp, Mark Purdie, Martin F. Jones, Alexandre Barthelme, John Pavey, Nikil Kapur, Thomas W. Chamberlain, A. John Blacker, Richard A. Bourne
Publikováno v:
Angewandte Chemie. 135
The optimization of multistep chemical syntheses is critical for the rapid development of new pharmaceuticals. However, concatenating individually optimized reactions can lead to inefficient multistep syntheses, owing to chemical interdependencies be
Autor:
Lucie Miller-Potucka, Gall Malcolm Allan Young, Ian W. Ashworth, Andrew J. Robbins, Oliver T. Ring, Martin F. Jones, Barry R. Hayter, Rosemary A. Wordsworth, Adam J. Leahy, Lyn Powell, Phillip A. Inglesby, Alex L. Lamacraft, Okky Dwichandra Putra, Janette H. Cherryman, Thomas O. Ronson, Peter R. Hamilton, Simone Tomasi, Lauren R. Agnew, David C. McKinney
Publikováno v:
Organic Process Research & Development. 26:936-948
Autor:
Dobson Benjamin Charles, Chris Wimsey, Lai C. Chan, Steven A. Raw, Anna Jawor-Baczynska, David R. J. Hose, Martin F. Jones, David Perkins, Alex L. Lamacraft, Angus E. McMillan, Matthew Burns, Alan Steven, Alexander K. Mullen, Phillip A. Inglesby, Ahmed Elmekawy, Michael John Pilling
Publikováno v:
Organic Process Research & Development. 25:858-870
Route design and process development of the small nitrogen heterocycle 2·HCl, a constituent of AZD5718 (1), is described. The novel synthetic sequence to 2.HCl involves a desymmetrizing alkylation ...
Autor:
Andrew Dalgleish, Keith R. Mulholland, Andrew D. Campbell, David Dave, Hannah Askey, Zhaoshan Cui, Gareth AstraZeneca R D Charnwood Ensor, Shenghua Wang, Peter R. Hamilton, Simone Tomasi, Mark A. Graham, Claire Heffernan, Lai Chan, Pengpeng Liu, Emma Randles, Martin F. Jones, Michael Popadynec, Dajiang Jing, Cooper Katie Grace, Mohammed Pervez, Maria Rita Galan Espinosa, Jackson Lucinda Victoria
Publikováno v:
Organic Process Research & Development. 25:43-56
Ceralasertib is currently being evaluated in multiple phase I/II clinical trials for the treatment of cancer. Its structure, comprising a pyrimidine core decorated with a chiral morpholine, a cyclo...
Autor:
Anna Pettersen, Martin F. Jones, Ronald John Roberts, Simon N. Black, Helen P. Wheatcroft, Ian Michael Mcfarlane
Publikováno v:
Journal of Pharmaceutical Sciences. 109:1509-1518
Cediranib maleate is an active pharmaceutical ingredient (API) in phase III of development within AstraZeneca's oncology portfolio. Analysis of the crystal structure of this API confirmed that the selected salt form was robust. The salt formation ste
Autor:
Sahar McKeever-Abbas, Robert L. Woodward, David Whittaker, Janette H. Cherryman, Alex Crampton, Edward G. B. Eden-Rump, Martin F. Jones, Matthew Charles Evans, Ian W. Ashworth, Rebecca E. Meadows, Phillip A. Inglesby, Andrew D. Campbell, Kathryn Skilling, Jemma Clark
Publikováno v:
Organic Process Research & Development. 22:1801-1808
We developed a scalable Suzuki process for the synthesis of lanabecestat (+)-camsylate, an active pharmaceutical ingredient that was recently investigated in a Phase III clinical program for the treatment of early Alzheimer’s disease. The evolution
Autor:
Martin Charles Bowden, A. John Blacker, Rachel H. Munday, Ben Crossley, Nisha P. B. Pokar, Jessica R. Breen, Martin F. Jones, Maria H. T. Kwan, Louis Conway, Thomas E. O. Screen
A new, dynamic diastereomeric crystallization method has been developed, in which the mother liquors are continuously separated, racemized over a fixed-bed catalyst, and recirculated to the crystallizer in a resolution-racemization-recycle (R3) proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf7fd791da4168c0ae810360b3b32d9
https://eprints.whiterose.ac.uk/169321/13/acs.joc.0c02617.pdf
https://eprints.whiterose.ac.uk/169321/13/acs.joc.0c02617.pdf
Autor:
Luke A. Power, Caroline Ainsworth, Martin F. Jones, Thomas W. Chamberlain, Adam D. Clayton, William R. Reynolds, Richard A. Bourne, David R. J. Hose, A. John Blacker
Downstream purification of products and intermediates is essential for the development of continuous flow processes. Described herein, is a study on the use of a modular and reconfigurable continuous flow platform for the self-optimisation of reactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa737538c4ea1584a5336f5e77e03ba3
https://eprints.whiterose.ac.uk/155776/19/Clayton2020_Article_Self-optimisingReactiveExtract.pdf
https://eprints.whiterose.ac.uk/155776/19/Clayton2020_Article_Self-optimisingReactiveExtract.pdf
Autor:
Lai Chun Chan, Ian W. Ashworth, Michael John Pilling, Alexander K. Mullen, Angus McMillan, Maria Rita Galan Espinosa, Steven A. Raw, Alan Steven, Martin F. Jones
Publikováno v:
The Journal of Organic Chemistry. 84:4629-4638
A selective aziridinium ring-opening was used to etherify an α-aryl-β-amino alcohol with stereochemical retention. This transformation was achieved in a biphasic system to address phenoxide solubility and the formation of a sulfonate ester impurity