Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Martin F. Engelke"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
The heterodimeric kinesin-2 motor (KIF3A/KIF3B with accessory protein KAP3) drives intraflagellar transport, essential for ciliogenesis and ciliary function. Three point mutations in the KIF3B subunit have recently been linked to disease in humans (E
Externí odkaz:
https://doaj.org/article/3b8534b4fd604a7f98f1e6e92fa0e53a
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109149- (2024)
Summary: Primary cilia are essential signaling organelles that protrude from most cells in the body. Heterodimeric kinesin-2 (KIF3A/KIF3B/KAP3) powers several intracellular transport processes, including intraflagellar transport (IFT), essential for
Externí odkaz:
https://doaj.org/article/a3d1e973d16446269a37c43b6eaeb5a5
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
How non-enveloped viruses cross host membranes is incompletely understood. Here, Ravindranet al. show that polyomavirus SV40 recruits kinesin-1 to construct a penetration site on the ER membrane.
Externí odkaz:
https://doaj.org/article/e5545009314d485fb97e3890a5478495
Autor:
Martin F. Engelke, Michael Winding, Yang Yue, Shankar Shastry, Federico Teloni, Sanjay Reddy, T. Lynne Blasius, Pushpanjali Soppina, William O. Hancock, Vladimir I. Gelfand, Kristen J. Verhey
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The use of specific small molecule inhibitors can contribute to the study of kinesins' cellular functions. Here the authors develop a chemical-genetic approach to engineer kinesin motors that can be efficiently inhibited upon addition of cell-permeab
Externí odkaz:
https://doaj.org/article/d400141931f143c5987411f968b209bc
Publikováno v:
Viruses, Vol 3, Iss 3, Pp 233-253 (2011)
Unlike transport vesicles or organelles, human adenovirus (HAdV) directly binds to the microtubule minus end-directed motor dynein for transport to the nucleus. The dynein cofactor dynactin enhances nuclear transport of HAdV and boosts infection. To
Externí odkaz:
https://doaj.org/article/f71d5a2de6254197b041da761f573663
Publikováno v:
Molecular biology of the cell. 33(1)
The kinesin-4 motor KIF7 is a conserved regulator of the Hedgehog signaling pathway. In vertebrates, Hedgehog signaling requires the primary cilium, and KIF7 and Gli transcription factors accumulate at the cilium tip in response to Hedgehog activatio
Autor:
William O. Hancock, Pushpanjali Soppina, T. Lynne Blasius, Michael Winding, Yang Yue, Shankar Shastry, Martin F. Engelke, Kristen J. Verhey, Federico Teloni, Vladimir I. Gelfand, Sanjay Reddy
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature communications
Nature Communications
Nature communications
Nature Communications
The human genome encodes 45 kinesin motor proteins that drive cell division, cell motility, intracellular trafficking and ciliary function. Determining the cellular function of each kinesin would benefit from specific small-molecule inhibitors. Howev
Autor:
Ayana Suber, Allison Boss, Sarah Kearns, Benjamin L. Allen, Kristen J. Verhey, Bridget Waas, Martin F. Engelke
Summary The trafficking of components within cilia, called intraflagellar transport (IFT), is powered by kinesin-2 and dynein-2 motors. Loss of function in any subunit of the heterotrimeric KIF3A/KIF3B/KAP kinesin-2 motor prevents ciliogenesis in mam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233d9ee6199b34c750281808ae8b7228
Publikováno v:
Biophysical Journal. 112:263a
Autor:
Zsolt Ruzsics, Corinne Wilhelm, Daniel Puntener, Urs F. Greber, Sten Strunze, Martin F. Engelke
Publikováno v:
Journal of virology
Human adenoviruses (Ads) replicate and assemble particles in the nucleus. They organize a linear double-strand DNA genome into a condensed core with about 180 nucleosomes, by the viral proteins VII (pVII), pX, and pV attaching the DNA to the capsid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde30be83c401b52dd9cb1e808b33909