Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Martin F. Engelke"'
Autor:
Juan Canchola, Gracious Yoofi Boafo Donkor, Patrick Ofori Tawiah, Ayoola Fasawe, Emmanuel Ayim, Martin F. Engelke, Jan-Ulrik Dahl
Publikováno v:
Antibiotics, Vol 13, Iss 9, p 897 (2024)
Background/Objectives. The rise of antibiotic-resistant pathogens represents a significant global challenge in infectious disease control, which is amplified by the decline in the discovery of novel antibiotics. Staphylococcus aureus continues to be
Externí odkaz:
https://doaj.org/article/6423e810c7894f029848902de71704a8
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
The heterodimeric kinesin-2 motor (KIF3A/KIF3B with accessory protein KAP3) drives intraflagellar transport, essential for ciliogenesis and ciliary function. Three point mutations in the KIF3B subunit have recently been linked to disease in humans (E
Externí odkaz:
https://doaj.org/article/3b8534b4fd604a7f98f1e6e92fa0e53a
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109149- (2024)
Summary: Primary cilia are essential signaling organelles that protrude from most cells in the body. Heterodimeric kinesin-2 (KIF3A/KIF3B/KAP3) powers several intracellular transport processes, including intraflagellar transport (IFT), essential for
Externí odkaz:
https://doaj.org/article/a3d1e973d16446269a37c43b6eaeb5a5
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
How non-enveloped viruses cross host membranes is incompletely understood. Here, Ravindranet al. show that polyomavirus SV40 recruits kinesin-1 to construct a penetration site on the ER membrane.
Externí odkaz:
https://doaj.org/article/e5545009314d485fb97e3890a5478495
Autor:
Martin F. Engelke, Michael Winding, Yang Yue, Shankar Shastry, Federico Teloni, Sanjay Reddy, T. Lynne Blasius, Pushpanjali Soppina, William O. Hancock, Vladimir I. Gelfand, Kristen J. Verhey
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The use of specific small molecule inhibitors can contribute to the study of kinesins' cellular functions. Here the authors develop a chemical-genetic approach to engineer kinesin motors that can be efficiently inhibited upon addition of cell-permeab
Externí odkaz:
https://doaj.org/article/d400141931f143c5987411f968b209bc
Publikováno v:
Viruses, Vol 3, Iss 3, Pp 233-253 (2011)
Unlike transport vesicles or organelles, human adenovirus (HAdV) directly binds to the microtubule minus end-directed motor dynein for transport to the nucleus. The dynein cofactor dynactin enhances nuclear transport of HAdV and boosts infection. To
Externí odkaz:
https://doaj.org/article/f71d5a2de6254197b041da761f573663
Publikováno v:
Molecular biology of the cell. 33(1)
The kinesin-4 motor KIF7 is a conserved regulator of the Hedgehog signaling pathway. In vertebrates, Hedgehog signaling requires the primary cilium, and KIF7 and Gli transcription factors accumulate at the cilium tip in response to Hedgehog activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a2ce618d70d953a4b8c225b71ef3d9
https://pubmed.ncbi.nlm.nih.gov/34705483
https://pubmed.ncbi.nlm.nih.gov/34705483
Autor:
William O. Hancock, Pushpanjali Soppina, T. Lynne Blasius, Michael Winding, Yang Yue, Shankar Shastry, Martin F. Engelke, Kristen J. Verhey, Federico Teloni, Vladimir I. Gelfand, Sanjay Reddy
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature communications
Nature Communications
Nature communications
Nature Communications
The human genome encodes 45 kinesin motor proteins that drive cell division, cell motility, intracellular trafficking and ciliary function. Determining the cellular function of each kinesin would benefit from specific small-molecule inhibitors. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf68a015fbe54a994b6674dcdf41d4c
https://doaj.org/article/d400141931f143c5987411f968b209bc
https://doaj.org/article/d400141931f143c5987411f968b209bc
Autor:
Ayana Suber, Allison Boss, Sarah Kearns, Benjamin L. Allen, Kristen J. Verhey, Bridget Waas, Martin F. Engelke
Summary The trafficking of components within cilia, called intraflagellar transport (IFT), is powered by kinesin-2 and dynein-2 motors. Loss of function in any subunit of the heterotrimeric KIF3A/KIF3B/KAP kinesin-2 motor prevents ciliogenesis in mam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233d9ee6199b34c750281808ae8b7228
Publikováno v:
Biophysical Journal. 112:263a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f429a18a948cb2de225c7742e68bc427
https://doi.org/10.1016/j.bpj.2016.11.1429
https://doi.org/10.1016/j.bpj.2016.11.1429